A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple SclerosisOriginal Research Published on 2021-03-222023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Adaptive immune response Autoimmunity Lymphocyte migration protein geranylgeranylation T cells [DOI] 10.3389/fimmu.2021.641188 PMC 바로가기 [Article Type] Original Research
Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection감염 후 6~8개월 후 회복 중인 COVID-19 환자에서 SARS-CoV-2 특이적 B 및 T 세포 반응의 지속성Article Published on 2021-03-122022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immune response adaptive immune responses addition anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Anti-spike antibody B cell binding domain center collected convalescent convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 Council Course COVID-19 COVID-19 patients COVID-19 research Critical disease declined development Diagnosis disease severity Donor elevated European Horizon IgG immune immune response immune responses Immunity Immunoglobulin immunoglobulin M immunological Immunological memory Infection information Italian Level Longevity longevity of immune response Medicine medium memory B Mild Ministry of Health monitoring National natural infection Neutralizing Neutralizing activity neutralizing antibody onset of symptom patients plasma Protective protective immunity provide remained Research respiratory SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly lower subset supported Swedish symptom onset T cell T cell response T cell responses tested the patient union vaccination Vaccination strategies Vaccination strategy variants virus [DOI] 10.1016/j.medj.2021.02.001 PMC 바로가기 [Article Type] Article
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged miceClinical and Translational Article Published on 2021-03-122022-11-01 Journal: Med (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Abstract Adaptive immune response administration Adults affected aging antibodies Antibody Response approach booster dose caused CD4 CD8 CD8+ T cells Cell cellular ChAdOx1 ChAdOx1 nCoV-19 changes in Clinical outcome Context COVID-19 COVID-19 vaccine COVID-19 vaccines effective effectors elicit ENhance finding follicular funding generate Germinal center Health Humoral immunity IgG and IgM immune response immune system immunogenicity induce Infection influence intramuscular limit magnitude Measures Medicine mice morbidity and mortality Older outcome performed plasma pre-clinical testing protective immunity reduced Regulatory required risk factor robust SARS-CoV-2 SARS-COV-2 infection second dose single dose single vaccination Spread stimulate supported T follicular helper cells Th1 cells vaccination Vaccine vaccine candidate virus-neutralizing antibodies worldwide pandemic [DOI] 10.1016/j.medj.2020.12.006 PMC 바로가기 [Article Type] Clinical and Translational Article
Renal Morphology in Coronavirus Disease: A Literature Review코로나바이러스 질병의 신장 형태: 문헌 검토Review Published on 2021-03-112022-09-10 Journal: Medicina [Category] SARS, 유전자 메커니즘, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response addition cascades Case report case reports Case series case sery caused change Collapsing conducted coronavirus coronavirus disease COVID-19 cytokine damage described Diseases focal segmental glomerulosclerosis genetic component glomerular glomerular diseases glomerulosclerosis help highlight histological Infection innate and adaptive immune response kidney Kidney failure kidney tissue kidneys leads lesion lesions literature mechanism morbidity Morphological morphological finding morphological findings Pathogenesis Patient patients procoagulant renal biopsy renal morphology respiratory review SARS-CoV-2 severe acute respiratory syndrome Coronavirus triggering Undetermined variety Vascular vascular diseases virus [DOI] 10.3390/medicina57030258 PMC 바로가기 [Article Type] Review
Population-Predicted MHC Class II Epitope Presentation of SARS-CoV-2 Structural Proteins Correlates to the Case Fatality Rates of COVID-19 in Different CountriesCommunication Published on 2021-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Adaptive immune response allele B-cell Case fatality rate country COVID-19 distributions early infection early phase envelope protein epitope epitope mapping Factor Fatality rate health system highlight histocompatibility immunological Infection infection spread lethality rate Linear regression Local Major measure membrane protein MHC class MHC class II MHC I MHC II MHCII Other Population population coverage potential risk predicted presentation Rate SARS-CoV-2 SARS-CoV-2 protein significant negative correlation Spread structural protein T-cell the SARS-CoV-2 viral envelope proteins viral spike protein [DOI] 10.3390/ijms22052630 PMC 바로가기 [Article Type] Communication
Investigation of immune cells on elimination of pulmonary-Infected COVID-19 and important role of innate immunity, phagocytes폐감염 COVID-19 제거에 대한 면역세포의 연구와 선천면역, 식세포의 중요한 역할Review Published on 2021-03-012022-09-12 Journal: Reviews in Medical Virology [Category] 진단, [키워드] Activation acute phase Adaptive immune response Adults alleviate antibody B cell cause CD4+ T cell CD4+ T cells children contribute COVID-19 COVID-19 infection Factor IgM and IgG Immune cell immune system Infection innate immune system Innate immunity investigation Mild much higher observation Patient patients phagocyte producing PROTECT required vaccination vaccine for COVID-19 white [DOI] 10.1002/rmv.2158 PMC 바로가기 [Article Type] Review
What do we know about the antibody responses to SARS-CoV-2?SARS-CoV-2에 대한 항체 반응에 대해 무엇을 알고 있습니까?Review Published on 2021-03-012022-09-12 Journal: Immunobiology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Adaptive immune response antibody antibody production convalescent patient convalescent plasma coronavirus COVID-19 deaths develop highlight Humoral response Immunity pandemic plasma SARS-CoV-2 SARS-COV-2 infection Scientific community Seroconversion Spread the antibody response Therapies Treatment Vaccine [DOI] 10.1016/j.imbio.2021.152054 PMC 바로가기 [Article Type] Review
Animal Coronaviruses Induced ApoptosisReview Published on 2021-02-262022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Adaptive immune response Alter animal animal coronavirus Animal coronaviruses antiviral target Apoptosis apoptotic pathway apoptotic pathways apoptotic signaling Cell cell death cell type cellular homeostasis cellular response clade coronavirus Coronavirus infection Critical death Evidence expected Future genetic diversity help host cell hosts identify induced Infection innate immune Interaction knowledge limit mechanism modulation molecular molecular mechanism pathogen Pathways proliferation promote recent Regulation Research SARS-CoV SARS-COV-2 infection Viral protein viral replication viruses [DOI] 10.3390/life11030185 PMC 바로가기 [Article Type] Review
SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and BeyondReview Published on 2021-02-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Adaptive immune response adaptive immune responses Adaptive immunity animal model antibodies B cell B cell response cells clinical study contribute coronavirus coronavirus disease COVID-19 develop effective Efficacy elicit germinal centers Human Immunity Infection long-lived plasma cells memory B cells Messenger RNA modulate mRNA mRNA vaccines pathogen post vaccination PROTECT Respiratory disease SARS-CoV-2 T cell T cell responses T follicular helper cells Th1 cells Vaccine while [DOI] 10.3390/vaccines9020147 PMC 바로가기 [Article Type] Review
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity420 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, [키워드] Adaptive immune response alteration Analysis Cell circulating Cluster contribute COVID-19 COVID-19 severity DCs decrease decreased expression disease dysregulation effort Frequency Immune cell immunopathology Infection Lineage Major MNP moderate monocyte Monocytes mononuclear phagocyte nonsurvivors Patient performed phenotypic pre-DCs precursors provide response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected patient severe COVID-19 severely sick patients severity Significance subset these cell viral infection while with COVID-19 [DOI] 10.1073/pnas.2018587118 PMC 바로가기 [Article Type] 420