Comparative Effectiveness of Coronavirus Vaccine in Preventing Breakthrough Infections among Vaccinated Persons Infected with Delta and Alpha Variants델타 및 알파 변이체에 감염된 백신 접종자의 돌발 감염 예방에 대한 코로나바이러스 백신의 비교 효과Research Published on 2022-02-012022-09-10 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] acute respiratory syndrome adjusted age Alpha Alpha variant Breakthrough infection breakthrough infections Comparative coronavirus coronavirus disease coronavirus variants COVID-19 Cycle threshold value Delta delta variant Diagnosis Effectiveness Infection Logistic regression mean difference mRNA vaccine mRNA vaccines Odds ratio Patient PCR cycle PCR-positive Person Portugal Preventing preventing infection reported respiratory respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Sex significantly higher threshold value used data vaccination Vaccination Status Vaccine vaccine-preventable diseases variant Viral Viral load viruses zoonoses [DOI] 10.3201/eid2802.211789 PMC 바로가기 [Article Type] Research
The N501Y spike substitution enhances SARS-CoV-2 infection and transmissionN501Y 스파이크 대체는 SARS-CoV-2 감염 및 전파를 향상시킵니다Article Published on 2022-02-012022-09-11 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] adaptive affinity airway Alpha Alpha variant approach B.1.1.7 B.1.1.7 variant Brazil cellular receptor cellular receptors convergent evolution COVID-19 pandemic Deletion deletions Efficiency eight ENhance epithelial cells Evolution genetics increase in Infection interact Mutation N501Y nonsynonymous mutation phenotype Prevalence primary human airway Primary human airway epithelial cells Replication SARS-CoV-2 SARS-COV-2 infection South Africa spike mutation Spike protein Substitution substitutions suggested summer The B.1.1.7 the spike protein Transmission tropism upper airway variant viral genome viral spike protein Viral transmission [DOI] 10.1038/s41586-021-04245-0 PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine : Secondary Analysis of a Randomized TrialmRNA-1273 백신 2회 및 3회 접종 후 이식 수혜자의 SARS-CoV-2 변이체 중화: 무작위 시험의 2차 분석Randomized Controlled Trial Published on 2022-02-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Alpha Alpha variant Analysis analyzed Antibody Response assays Beta Beta variant Controlled trial COVID-19 delta variant Delta variants dose doses double-blind increase lentivirus mRNA mRNA vaccine mRNA-1273 mRNA-1273 vaccine neutralization neutralizing antibody Neutralizing antibody response neutralizing antibody responses Organ transplant Patient percentage points Placebo placebo group positive proportion Pseudovirus neutralization assay Randomized recipient recipients SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants secondary sera the placebo group Transplant vaccine doses vaccine immunogenicity variant variants Virus neutralization viruses wild-type virus [DOI] 10.7326/M21-3480 PMC 바로가기 [Article Type] Randomized Controlled Trial
No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway노르웨이에서 보고된 SARS-CoV-2 Delta 변이형과 Alpha 변이형 사이에 입원 위험에 차이가 없음Article Published on 2022-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha Alpha variant aRR calculated cohort study Comorbidities conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 Delta delta variant demographic characteristics diagnosed Hospitalization Hospitalized laboratory-confirmed no difference Norway reduced risk reported risk risk ratio sampling SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support the SARS-CoV-2 vaccination Vaccination Status variant variants variants of concern [DOI] 10.1016/j.ijid.2021.12.321 PMC 바로가기 [Article Type] Article
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants칸나비노이드는 SARS-CoV-2 및 새로운 변이체의 세포 진입을 차단합니다Article Published on 2022-01-282022-09-11 Journal: Journal of natural products [Category] Coronavirus, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affinity Alpha Alpha variant B.1.1.7 B.1.351 Beta variant block cannabinoid cannabinoids cannabis cells complement Coronavirus-2 COVID-19 effective epithelial cells expressing Follow-up hemp human epithelial cell human epithelial cells Infection Ligand live SARS-CoV-2 mass spectrometry Prevent prevented pseudovirus Safe SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the SARS-CoV-2 the spike protein therapeutic agent treat Vaccines variant variants virus neutralization assays was used [DOI] 10.1021/acs.jnatprod.1c00946 PMC 바로가기 [Article Type] Article
Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tractCoronaviruses Published on 2022-01-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] air–liquid interface airway epithelial cell Alpha variant blockade circulating circulation coronavirus 2 correlated COVID-19 had no IAV IBV immune response Infection Influenza Influenza virus inhibition Interaction interferon interferons investigated modulate modulated neutralizing antibody other respiratory virus pandemic patients prevalent prevented question Replication replicative reported respiratory respiratory virus respiratory viruses restored rhinovirus SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 replication suggested These data triggered type I upper respiratory tract variants of concern viral co-infections virus virus entry was impaired [DOI] 10.1080/22221751.2021.2021806 PMC 바로가기 [Article Type] Coronaviruses
SARS-CoV-2 Spike-Specific CD4+ T Cell Response Is Conserved Against Variants of Concern, Including OmicronSARS-CoV-2 스파이크 특이적 CD4+ T 세포 반응은 오미크론을 포함한 우려 변종에 대해 보존됩니다Immunology Published on 2022-01-262022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] accumulating Administered Against Alpha Alpha variant antibody Antibody neutralization Beta CD4 CD4+ CD4+ T cell cellular immunity concern conserved country COVID-19 COVID-19 case COVID-19 cases Defense Delta Delta variants evade form Immunity Implications Including individual Infection investigated less majority memory memory response mRNA vaccination mutated natural infection Neutralizing activity observation omicron PROTECT Protein Region response responsible SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variant spike Spike protein subject T cell T cell response T cells target Transmissibility vaccination vaccine dose variant variants variants of concern (VOCs) Wuhan strain [DOI] 10.3389/fimmu.2022.801431 PMC 바로가기 [Article Type] Immunology
Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA VaccinationmRNA 백신 접종 후 치명적인 코로나19 감염에 대한 중간 정도의 면역 반응Immunology Published on 2022-01-252022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, 치료기술, 치료법, 치료제, [키워드] Alpha Alpha variant Alpha VOC analyzed anti-SARS-CoV-2 vaccination Antibody titers antigenic target Breakthrough infection CD4+ CD4+ T-cell CD8+ T cell CD8+ T cells cellular Cohort COVID-19 COVID-19 disease detectable disease manifestation disease onset Disease progression donors Endemic fatal COVID-19 had no humoral immune response Humoral immunity Inclusion indicate individual moderate mounted mRNA mRNA-based Neutralizing antibodies Neutralizing antibody titer Patient reduced response resulting robust S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants T cells T-cell Response Trigger uninfected Vaccination strategy Vaccine vaccine breakthrough infection variant VoC VOCs wild type [DOI] 10.3389/fimmu.2022.816220 PMC 바로가기 [Article Type] Immunology
Early effectiveness of BNT162b2 Covid-19 vaccine in preventing SARS-CoV-2 infection in healthcare personnel in six Israeli hospitals (CoVEHPI)BNT162b2 코비드-19 백신이 이스라엘 6개 병원(CoVEHPI)의 의료진에서 SARS-CoV-2 감염을 예방하는 초기 효과Article Published on 2022-01-242022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] 95% CI adjusted Alpha Alpha variant BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 mRNA vaccine circulation conducted COVID-19 vaccination COVID-19 vaccine Cox proportional hazards model creating dose Effectiveness Endpoint enrolled Enrollment evaluate event first dose Fisher Fisher's exact test follow-up period hazard hcp healthcare personnel hospital Infection nasal National nine of BNT162b2 participant Participants PCR PCR-confirmed PCR-positive Pfizer predominant primary analysis proportional hazards model Prospective Study provided Questionnaires SARS-COV-2 infection Seroconversion serology specimens study participant Study participants Surveillance Symptom uninfected participant vaccination Vaccine variant [DOI] 10.1016/j.vaccine.2021.11.092 PMC 바로가기 [Article Type] Article
Surveillance Web System and Mouthwash-Saliva qPCR for Labor Ambulatory SARS-CoV-2 Detection and Prevention분만 이동 SARS-CoV-2 감지 및 예방을 위한 감시 웹 시스템 및 구강 세척제-타액 qPCRArticle Published on 2022-01-242022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 치료기술, 치료제, [키워드] Algorithm Alpha Alpha variant ambulatory applied Asymptomatic baseline Community conducted copy number coronavirus COVID-19 database Decision-making detection Detection limit development effective epidemiological epidemiological surveillance Evidence evidence of Follow-up house individual labor Laboratory Mild moderate monitoring Mouthwash N-gene nasopharyngeal swabbing platform populations prevention primer Primers protocol provide provided qPCR RT-qPCR RT-qPCR test Safe SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 testing sensitivity specificity specimen statistical Surveillance symptomatic symptomatic case System threshold Viral virus virus inactivation volunteers Web work environments [DOI] 10.3390/ijerph19031271 PMC 바로가기 [Article Type] Article