MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 programMBD2는 대식세포 M2 프로그램을 억제하여 폐 섬유증에 대한 실행 가능한 표적으로 작용합니다.Article Published on 2021-01-012022-09-11 Journal: Science Advances [Category] 유전자 메커니즘, [키워드] administration binding domain Bleomycin BLM characterized clinical settings coronavirus disease Coronavirus disease 2019 deficiency demonstrated Depletion domain expression fibrosis growth idiopathic inhibiting Interstitial lung disease intratracheal administration Liposome lung Lung disease lung injuries Lung injury Lungs M2 macrophage Macrophage macrophages Mbd2 mechanism mice Patient PI3K promote promoter pulmonary fibrosis reduced repressed Signaling significantly siRNA Support Systemic sclerosis TGF-β1 [DOI] 10.1126/sciadv.abb6075 PMC 바로가기 [Article Type] Article
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 임산부 및 신생아 SARS-CoV-2 바이러스 부하, Transplacental Antibody Transfer 및 태반 병리 평가Research Published on 2020-12-222022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age Analysis angiotensin angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody antibody transfer assessment Asymptomatic binding domain biofluids Biological Blood Boston Care Chain Reaction Characteristics cohort study Colocalization Compromised conducted Cord blood coronavirus COVID-19 Critical disease defined detectable disease distribution enrolled enzyme Evidence evidence of exposure expression of SARS-CoV-2 fetoplacental finding Follow-up Immunity implication Importance incidence inefficient Infection Influenza load Massachusetts Maternal maternal plasma measure mechanism Mild Mild disease moderate disease Nasopharyngeal swab Neonatal Neonate Neonates no evidence of nucleocapsid objective occurred outcome participant pathology Placenta placental Placental infection Placentas plasma Point positive pregnancies Pregnancy pregnant women presenting prospective cohort study protective mechanism protective mechanisms provided quantification quantified receptor recruited reduced Relevance respiratory respiratory fluid Result risk robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 RNA SARS-CoV-2 viral load Serine setting severe disease significantly lower tertiary care center tested transfer transmembrane serine protease transmembrane serine protease 2 Transmission transmission of SARS-CoV-2 Transplacental transplacental passage umbilical Umbilical cord underlie vertical transmission Viral Viral load Viremia women [DOI] 10.1001/jamanetworkopen.2020.30455 PMC 바로가기 [Article Type] Research
Druggability for COVID-19: in silico discovery of potential drug compounds against nucleocapsid (N) protein of SARS-CoV-2Original Article Published on 2020-12-092022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antiviral drug approaches binding affinities binding affinity binding domain caused Compound conserved contagious coronavirus coronavirus disease COVID-19 creating Critical disease domain drug drug target druggability function Good Hydrogen bond identify in silico molecular docking Molecular modeling morbidity Mortality N protein nucleocapsid nucleocapsid protein offer Phylogenetic relationship Protein Region researcher RNA SARS-CoV-2 SARS-COV-2 infection selected sequence the SARS-CoV-2 these compounds Treatment Vaccine Vaccine development viral life cycle viral replication virus widespread [DOI] 10.5808/GI.2020.18.4.e43 PMC 바로가기 [Article Type] Original Article
Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort studySARS-CoV-2 유발 ARDS의 생체분포 및 혈청학적 반응: 코호트 연구Research Article Published on 2020-11-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, [키워드] 30-Day mortality accompanied acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antibody Antibody detection antibody formation Antiviral treatment ARDS binding domain biodistribution blood sample Blood samples Chain Reaction cohort study collected Concentration coronavirus COVID-19 detectable dialysate disease severity distribution enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay high viral load ICU treatment IgA antibodies IgA antibody IgM intensive care intensive care treatment investigated majority Most patient Most patients Neutralizing Neutralizing antibodies neutralizing antibody no difference non-survivor Non-survivors oropharyngeal swab oropharyngeal swabs Patient patients polymerase chain polymerase chain reaction positive Quantitative RBD remained respiratory respiratory distress Result retrospective reverse transcription reverse transcription quantitative polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load serologic Serologic response serologic testing severe acute respiratory syndrome Coronavirus severe ARDS severe corona virus disease significantly lower single-center study suffered survival survivor syndrome tested the patient tissue tracheal Tracheal aspirates Viral Viral load Virus Disease was performed [DOI] 10.1371/journal.pone.0242917 PMC 바로가기 [Article Type] Research Article
Antibody profiling and prevalence in US patients during the SARS-CoV2 pandemicResearch Article Published on 2020-11-192022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Accuracy affected analyzed antibody Antibody Response binding domain clinical sensitivity collected detect Developing diagnostics disease detection flexible glycoprotein handling IgA IgG IgM immune response Immunity imperative methodology Microarray microbial minimum multiplex novel antigen Novel coronavirus NP swab nucleoprotein outbreak pandemic Pandemics Patient platform Prevalence processed Protein RBD reliability Result risk RT-PCR SARS-CoV2 Sensitivity and specificity serum serum samples specificity spot SST Variation virus Volume was used [DOI] 10.1371/journal.pone.0242655 PMC 바로가기 [Article Type] Research Article
Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamianaArticle Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibody bind binding binding domain Biotechnology coronavirus disease Coronavirus-2 COVID-19 CR3022 diagnostic reagent Disease diagnosis drugs Epidemic exhibited expression expression level global public health highest immunology in vitro mAb Molecular biology monoclonal antibody neutralize Nicotiana benthamiana outbreak pandemic plant Plant sciences plants platform produced producing Protein Rapid RBD reagent receptor Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 receptor spread of COVID-19 the SARS-CoV-2 Treatment Vaccines virus [DOI] 10.1038/s41598-020-74904-1 PMC 바로가기 [Article Type] Article
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2Article Published on 2020-09-292022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome bats binding binding domain complex coronavirus COVID-19 Cryo-electron microscopy cryo-EM Cryoelectron microscopy facilitate hACE2 highlight Host host range human ACE2 molecular basis Molecular biology Outbreaks pandemic Prevent RBD receptor reported resolved SARS-CoV SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 receptor screened susceptible the SARS-CoV-2 wild animals [DOI] 10.1038/s41421-020-00210-9 PMC 바로가기 [Article Type] Article
Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings여러 COVID-19 혈청 기술에 대한 비교 평가는 병원 및 지역사회 의료 환경에서 현장 진료 측면 흐름 분석의 지속적인 평가를 지원합니다.Research Article Published on 2020-09-242022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] Analysis Anti-spike antibody antibody levels Antibody test antibody test kits Antibody testing antibody tests approved Asymptomatic best binding domain Blood chemiluminescence chemiluminescence-based platform colloidal gold Community Comparative complement conducted COVID-19 delayed-onset syndrome delayed-onset syndromes dependent on determine Diagnosis diagnostic diagnostic antibody diagnostic antibody test diagnostic capabilities diagnostic capability disease ELISA evaluated gold head Head-to-head comparison healthcare hospital house in-house ELISA in-house ELISAs individual Inflammatory lateral flow lateral flow immunoassay Lateral flow immunoassays London management Mild multiple sero-diagnostic assay multiple sero-diagnostic assays nose swab Novel coronavirus nucleocapsid onset of symptoms paediatric inflammatory multisystem syndrome past Patient Patient management PCR-based throat and nose swab tests PIMS platform point-of-care point-of-care technology rapid lateral flow immunoassays RBD Receptor binding domain sampling SARS-CoV-2 SARS-CoV-2 antibody test SARS-CoV-2 infections sensitivities sensitivity serological Seven shown specificity Support Symptoms syndrome the epidemic utility Variation variety virus with COVID-19 [DOI] 10.1371/journal.ppat.1008817 PMC 바로가기 [Article Type] Research Article
Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In Silico AnalysisResearch Article Published on 2020-09-172022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyzed Antigen antigenic antigenic peptide antigenicity B cell binding domain C-terminal caused CD4 CD8 chimeric coronavirus COVID-19 creating effective Efficiency expression humans hypersensitivity reaction immunogenic In silico cloning in viral linear epitope MHC-I MHC-II alleles molecular docking molecular interaction N-terminal novel coronavirus disease nucleocapsid protein pandemic peptide Phosphoprotein predicted provide public health Replication Research RNA Safe SARS-CoV-2 selected Selected epitopes T cell epitope targeting the SARS-CoV-2 the vaccine TLR5 Toxicity translation triggered Vaccine was performed [DOI] 10.1155/2020/2837670 PMC 바로가기 [Article Type] Research Article
Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domainACE2-Fc 융합 단백질의 완전히 당화된 분자 모델의 개발 및 시뮬레이션 및 SARS-CoV-2 스파이크 단백질 결합 도메인과의 상호 작용Research Article Published on 2020-08-052022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor ACE2-Fc Algorithm Algorithms binding domain conformation COVID-19 develop development fragment fragment of fusion protein glycan glycans glycosylated glycosylation Interaction molecular molecular dynamics Protein RBD Receptor-binding domain SARS-CoV-2 virus Spike protein Spike Protein S target targets tested the receptor-binding domain the SARS-CoV-2 the SARS-CoV-2 virus the Spike therapeutic [DOI] 10.1371/journal.pone.0237295 PMC 바로가기 [Article Type] Research Article