The Redox Role of G6PD in Cell Growth, Cell Death, and CancerReview Published on 2019-09-082023-08-30 Journal: Cells [Category] E형 간염, [키워드] Cancer cell death cell growth G6PD redox signaling [DOI] 10.3390/cells8091055 PMC 바로가기 [Article Type] Review
Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2Research Paper Published on 2019-07-252022-10-29 Journal: International Journal of Biological Sciences [Category] Coronavirus, [키워드] activated Activation B cell caused Cell cell death characterized Circular circular RNA contagious coronavirus demonstrated diarrhea down-regulated epithelial cell line gastroenteritis Hexokinase HK2 IL-6 Infection Infectious disease Inflammation inhibited intestinal microRNA mitochondrial mitochondrial permeability transition pore NF-κB NF-kB pathway NF-κB NF-κB pathway nuclear opening permeability Pore promoted provoke regulate regulated responsible RNA suppressed target targeting TGEV transition transmissible gastroenteritis coronavirus virus vomiting [DOI] 10.7150/ijbs.36532 PMC 바로가기 [Article Type] Research Paper
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSRetrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다Research Article Published on 2017-03-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase [DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L ActivationResearch Article Published on 2016-03-292022-10-29 Journal: mBio [Category] Coronavirus, [키워드] accessory protein activate Activation acute respiratory syndrome antiviral activity betacoronavirus calu-3 cells cell death characterized cleave contribute coronavirus Coronaviruses CoV Critical cytoplasmic dsRNA enzyme expressed expression level genes encoding Genome highly pathogenic homolog Host host antiviral response host innate immunity IFN IFN signaling in vivo model inactivation Infection Innate immunity interferon involved Like Lineage mechanism MERS MERS-CoV MERS-CoV infection Middle East murine mutant NLS NS2 NS4b nuclear localization signal nucleus offer other coronaviruses Pathogenesis pathway potential mechanism Prevent Protein provide Replication reported required respiratory respiratory syndrome coronavirus RNA RNase SARS-CoV single-stranded Spread ssRNA subsequent therapeutic intervention translational type I interferon viral double-stranded RNA viral pathogenesis viral replication virulence [DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article
From bedside to bench and back again—molecular mechanisms in acute liver failureArticle Published on 2014-01-302023-08-30 Journal: Frontiers in Physiology [Category] E형 간염, [키워드] acute liver failure cell death ethiology molecular mechanisms therapeutic options [DOI] 10.3389/fphys.2014.00018 PMC 바로가기
Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors원추형 광수용체에서 Ranbp2의 특정 제거 시 광수용체 세포 유형 간의 고유하고 비정형적인 고유 및 외인성 세포 사멸 경로Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation Activation acute transverse myelitis affecting Apoptosis approaches arise Author base cascade caspase caspase-3 caspase-7 caspase-9 cause Cell cell death clinical manifestations cone cone photoreceptor contribute death degenerate degeneration demise develop Diseases disintegration downstream driving event expression extrinsic Factor followed by found Gene Genes Genetic genetic defect hallmark healthy heterogeneous implicated intrinsic intrinsically manifestation mechanism membrane permeability metalloproteinase modulation molecular mosaic multifunctional protein Mutation Myelitis necrotic neural retina neurodegeneration neurodegenerative neurodegenerative disorders Neuron neurons neuroprotection PARP1 pathway Pathways photoreceptor photoreceptors pleiotropic progression progression of disease promote Protein Ranbp2 rod rod photoreceptor rod photoreceptors rods spatiotemporal Specific Stressor subcellular therapeutic thought transverse myelitis Trigger triggered Tumor Type undergo underlying disease underlying diseases up-regulation [DOI] 10.1371/journal.pgen.1003555 PMC 바로가기 [Article Type] Research Article
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article
Involvement of FOXO Transcription Factors, TRAIL-FasL/Fas, and Sirtuin Proteins Family in Canine Coronavirus Type II-Induced ApoptosisResearch Article Published on 2011-11-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activate Activation addition Analysis Blot canine cell death cell line cells coronavirus cytosol decrease demonstrated Effect expression extrinsic extrinsic apoptosis family found FoxO FOXO1 In vitro infection increase in induce Infection intrinsic apoptotic pathway investigated involved Involvement Ligand mitochondrial nuclear pathway post infection pro-apoptotic Protein protein expression Proteins regulate shown significantly SIRT1 SIRT3 SIRT4 sirtuin TRAIL transcription factor translocation Type virus infection [DOI] 10.1371/journal.pone.0027313 PMC 바로가기 [Article Type] Research Article