Analysis of the humoral and cellular immune response after a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors with or without chemotherapy: an update after 6 months of follow-up화학 요법의 유무에 관계없이 PD-1/PD-L1 억제제로 치료받은 암 환자에서 BNT162B2 항 -SARS-COV-2 백신의 전체 과정 후 체액 및 세포 면역 반응의 분석 : 6 개월의 추적 관찰 후 업데이트Article Published on 2022-02-012022-08-31 Journal: ESMO open [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Analysis analyzed anti-SARS-CoV-2 Anti-spike antibody B.1.1 strain BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine BNT162b2 vaccine Cancer cancer patient Cancer patients Cell cell death cell-mediated immune cell-mediated immune response Cellular immune response chemo-immunotherapy Chemotherapy Concentration correlation Course COVID-19 vaccine dose enrolled enzyme enzyme-linked immunosorbent evaluated Follow-up highlight humoral IFN-γ immune response immunogenicity Immunoglobulin Immunoglobulin G Immunotherapy inhibitor inhibitors interferon-γ interquartile range IQR median mononuclear cells naïve naïve subjects Neutralizing neutralizing antibody of BNT162b2 Patient PD-1/PD-L1 inhibitors Peripheral blood Peripheral blood mononuclear cells previous study programmed cell death programmed cell death protein Protein quantification quantified reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serum samples significant decrease significantly lower spike-specific T-cell spike-specific T-cell response subject subjects Support T-cell Response the vaccine third dose treated triggering vaccination Vaccine was used [DOI] 10.1016/j.esmoop.2021.100359 PMC 바로가기 [Article Type] Article
Humoral and cellular immune responses on SARS-CoV-2 vaccines in patients with anti-CD20 therapies: a systematic review and meta-analysis of 1342 patients항-CD20 요법을 받는 환자의 SARS-CoV-2 백신에 대한 체액 및 세포 면역 반응: 1342명의 환자에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-012022-09-12 Journal: RMD Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI anti-CD20 Anti-CD20 antibodies anti-CD20 therapy antirheumatic agents Autoimmune Autoimmune disease Autoimmune diseases B cell Bern Blood cell-mediated immune cell-mediated immune response Cellular immune response circulating conducted courses COVID COVID-19 criteria develop Endpoint excluded heterogeneity high risk humoral humoral responses kidney transplant recipient limitation malignancy Meta-analysis methodology participant Patient patients patients with haematological personalised Potential proportions random-effects model receiving response rituximab SARS-CoV-2 vaccination SARS-CoV-2 vaccine searched SSRN subgroup subgroup analysis systematic review therapy treated university vaccination Vaccine Variation were assessed [DOI] 10.1136/rmdopen-2021-002036 PMC 바로가기 [Article Type] Meta-Analysis
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group건강한 인구집단에서 CoronaVac 28일 일정 예방접종으로 유도된 면역 반응 평가Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, 진단, [키워드] administration Analysis anti-spike antibodies anti-spike antibody Cell cellular Cellular immune response cellular immune responses CoronaVac COVID-19 Effectiveness ELISPOT evaluate granzyme granzyme B group herd immunity Hospitalization humoral immune response IFN-gamma immune memory immune response immune responses immunization Immunological memory increase in induce induced life memory Negative PCR Neutralizing Neutralizing antibodies Population recruited response robust SARS-CoV-2 SARS-CoV-2 spike protein schedule Science Sinovac Spike protein vaccination schedule Vaccine Volunteer [DOI] 10.3389/fimmu.2021.766278 PMC 바로가기 [Article Type] Immunology
Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare WorkersArticle Published on 2022-01-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered All participant Analysis anti-Spike IgG B cell baseline blood sample booster booster dose Cellular immune response cellular immunity ChAdOx1 ChAdOx1 nCoV-19 CoronaVac COVID-19 COVID-19 pandemic Decline dose early phase ELISA ELISPOT evaluate function healthcare healthcare worker humoral Humoral immunity IgG Immunity immunogenicity indicated neutralizing antibody PROTECT provided random SARS-CoV-2 significantly higher stratified T cell third dose Twenty participant vaccination Vaccine Vaccines were measured worker [DOI] 10.3390/vaccines10020217 PMC 바로가기 [Article Type] Article
Predicted HLA Class I and Class II Epitopes From Licensed Vaccines Are Largely Conserved in New SARS-CoV-2 Omicron Variant of Concern허가된 백신에서 예측된 HLA 클래스 I 및 클래스 II 에피토프는 우려의 새로운 SARS-CoV-2 오미크론 변이체에서 크게 보존됩니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] alleles analyzed cellular Cellular immune response class concern contagious Critical cytotoxic Efficacy elicited epitope Epitopes escape mutant escape mutation facilitate HLA HLA class 1 HLA class 2 HLA class I HLA class I and II alleles human population immune protection immune responses issue Mutation New new SARS-CoV-2 omicron SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants These data Vaccine vaccine efficacy variant virus [DOI] 10.3389/fimmu.2022.832889 PMC 바로가기 [Article Type] Immunology
Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting TherapyB 세포 고갈 요법을 받는 ANCA 관련 혈관염 환자에서 SARS-CoV-2 백신 접종 후 항원 특이적 체액 및 세포 면역Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] ANCA-associated vasculitis anti-CD20 anti-CD20 therapy anti-SARS-CoV-2 Anti-spike antibody assays B-cell B-cells cellular Cellular immune response characterized control subjects controls COVID-19 vaccination elicit ELISPOT enzyme-linked immunosorbent humoral humoral immune response Humoral response immune responses immunoassays interferon lack mounted Patient patients peptide peptide pool positive Protective protective effect receiving Receptor binding domain recovered patient Research response rituximab robust S glycoprotein SARS-CoV-2 SARS-CoV-2 vaccination Specific Specific T-cell response subject subjects subunit T-cell immunity T-cell Response T-cell responses targeted therapy vaccination Vaccine vaccine response Vasculitis were measured [DOI] 10.3389/fimmu.2022.834981 PMC 바로가기 [Article Type] Immunology
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs새로운 STING 효능제가 첨가된 범-사베코바이러스 백신은 마우스, 토끼 및 NHP에서 강력하고 내구성 있는 중화 항체 및 T 세포 반응을 이끌어냅니다.Article Published on 2022-01-192022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] alum Cellular immune response CoVs Diseases elicit elicited exhibited Final hACE2 highlight highly pathogenic humoral immune responses immunization immunized immunology initial Innate immunity lower airway macaque mice Molecular biology NAb NAbs neutralizing antibody NHP NHPs nine outbreak produced RBD-Fc reduced responses against rhesus macaque rhesus macaques sarbecovirus SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARSr-CoVs significantly single dose STING T cell T cell response T cell responses upper and lower airways Vaccine Vaccines variant Viral Viral load [DOI] 10.1038/s41422-022-00612-2 PMC 바로가기 [Article Type] Article
Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-BSARS-COV-2 mRNA 백신 PTX-Covid19-B의 전임상 평가Research Article Published on 2022-01-192022-09-10 Journal: Science Advances [Category] 변종, 비임상, 신약개발, 진단, [키워드] adverse effect adverse effects Alpha Beta breath candidate Cellular immune response clinical trial clinical trials COVID-19 pandemic Delta description effective effective vaccine elicited Gamma hamster hamsters Health Canada humoral immune immune responses immunogenic indicated initial lineages lung mice mouse mRNA vaccine neutralize Neutralizing antibody response Phase 2 Preclinical respiratory robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sera the strongest upper respiratory tract vaccination [DOI] 10.1126/sciadv.abj9815 PMC 바로가기 [Article Type] Research Article
Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2SARS-CoV-2에 감염된 임산부의 모체-태아 면역 반응Article Published on 2022-01-182022-09-10 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] actual risk Blood cells Cellular immune response circulation Cord blood COVID-19 cytokine cytokine response detectable during pregnancy fetal high-risk population humoral Humoral and cellular immune responses IgM responses immune evasion immune response immune responses induce infected with SARS-CoV-2 Infection Inflammatory response initiated involved maternal blood Mild Mortality Neonatal Placenta placental Placental infection Pregnancy pregnant women provide Reproductive signs and symptoms SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 SARSCoV-2 infection sterility stromal cells T cell T cells T-cell tissues Trigger triggered triggers Umbilical cord umbilical cord blood undetectable unique Viral viral infection virus women [DOI] 10.1038/s41467-021-27745-z PMC 바로가기 [Article Type] Article
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2 감염 중 면역 역학의 연령 관련 차이Research Article Published on 2022-01-172022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] advanced age age aging Analysis animal animals Antiviral Bronchoalveolar lavage fluid Cellular immune response cellular immune responses clinical observations Clinical signs cohorts cytokine cytokine level cytokine levels difference disease eight evaluated exhibited flow cytometry immune Immune homeostasis immune response immune responses immunohistochemistry impair Increased inflammation-associated gene inflammation-associated genes Inflammatory Innate immune defense innate immune defenses inoculated lipid mediator Local macaque mediator multiplex Older outcomes pro-inflammatory response pulmonary infiltrates responses return rhesus rhesus macaque rhesus macaques risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single-cell Single-cell transcriptomics sustained T-cell Response T-cell responses Thoracic transcriptomics various tissues Viral viral RNA quantification virus replication [DOI] 10.26508/lsa.202101314 PMC 바로가기 [Article Type] Research Article