Digital oximetry biomarkers for assessing respiratory function: standards of measurement, physiological interpretation, and clinical useArticle Published on 2021-01-042022-10-04 Journal: NPJ Digital Medicine [Category] 바이오마커, [키워드] Analysis Biomarker Blood Clinical use clinically Continuous data contrary contributed creating Diagnosis Diagnostic markers Digital Diseases ENhance etiology high correlation identify individual information Interpretation manifestation Measures Mild moderate MONITOR obstructive sleep apnea Organ failure OSA oxygen oxygen saturation physiological Predictive markers Prognostic markers provided Python reached reference regression analysis Research respiratory diseases resulting tissues Variability [DOI] 10.1038/s41746-020-00373-5 PMC 바로가기 [Article Type] Article
Biotechnology, nanotechnology and medicineBiotechnology Published on 2020-12-172022-10-31 Journal: Emerging Topics in Life Sciences [Category] Coronavirus, MERS, SARS, [키워드] age Antibiotic resistance approach approaches approval benefit Biotechnology cancers changes in circumvent Clinical use COVID 19 detect diagnostic disease Diseases drug drugs immune response IMPROVE increasingly interactions Moderna MONITOR nanomedicine Nanotechnology New pandemic pharmacological problem receiving regenerative Regulation Research starting point translational science treat Treatment Tuberculosis Vaccine Vaccines while [DOI] 10.1042/ETLS20200350 PMC 바로가기 [Article Type] Biotechnology
Validation and repurposing of the MSL-COVID-19 score for prediction of severe COVID-19 using simple clinical predictors in a triage setting: The Nutri-CoV scoreResearch Article Published on 2020-12-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95%CI age Care Chronic kidney disease clinical assessment Clinical use COPD COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 severity Cox regression Critical death diabetes Elastic eligibility ICU admission Immunosuppression include Mexicans Mortality obesity Patient patients evaluated Pneumonia predict predictor pulse oximetry requirement for intubation respiratory rate Result risk stratification severe COVID-19 severe disease severity severity scores type 2 diabetes validation validation cohort variable [DOI] 10.1371/journal.pone.0244051 PMC 바로가기 [Article Type] Research Article
Reliable and accurate diagnostics from highly multiplexed sequencing assays고도로 다중화된 시퀀싱 분석에서 신뢰할 수 있고 정확한 진단Article Published on 2020-12-102022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] Algorithms Analysis Clinical use Computational biology and bioinformatics diagnostic diagnostic tests diagnostics effective High-throughput sequencing Infectious diseases Interpretation kallisto memory Novel coronavirus pandemic principle robust RT-qPCR SARS-COV-2 infection SARS-CoV-2 sequencing secure Sequencing sequencing data statistical [DOI] 10.1038/s41598-020-78942-7 PMC 바로가기 [Article Type] Article
COVID-19 mortality risk assessment: An international multi-center studyCOVID-19 사망률 위험 평가: 국제 다기관 연구Clinical Trial Published on 2020-12-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 임상, [키워드] 95% CI age Algorithm AUC Blood Blood urea nitrogen C-reactive protein calculator Clinical features Clinical findings Clinical use Cohort collected COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 positive patient creatinine data-driven demographic develop elevated Europe evaluated generate group high risk Hospital admission hospitalized COVID-19 patients hospitals IMPROVE Increased independent international multi-center Laboratory management Mortality mortality rate mortality risk nitrogen oxygen oxygen saturation Patient Patient management patients predict resource risk Risk factors significantly The United States United States urea validation cohorts variable was obtained [DOI] 10.1371/journal.pone.0243262 PMC 바로가기 [Article Type] Clinical Trial
Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analysesResearch article Published on 2020-12-062022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료제, [키워드] acute phase addition Analysis Anti-inflammatory therapy antiviral drug bioinformatics Blood candidate drug cells Chloroquine Clinical use Controlled clinical trial correlated correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Cytokine release syndrome Cytokine storm decrease drug Effect effective evaluated Gene Expression Gene expression analysis gene signature glucocorticoid high mortality rate Hydroxychloroquine IFN-α IFN-β IFN-γ IL6 immune inhibitor interferons lung tissue Macrophage mechanism network analysis neutrophil novel coronavirus SARS-CoV-2 pathogenic Pneumonia receptor regimen SARS-CoV-2 suggested TNF TNFα Tocilizumab Transcriptome Treatment triggered Vaccine [DOI] 10.1016/j.csbj.2020.11.056 [Article Type] Research article
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models하이드록시클로로퀸 예방 및 치료는 원숭이와 햄스터 SARS-CoV-2 질병 모델에서 효과가 없습니다Research Article Published on 2020-12-032022-09-10 Journal: JCI Insight [Category] MERS, SARS, 신약개발, 진단, 치료제, [키워드] animal model benefit clinical disease Clinical outcome clinical trial Clinical use COVID-19 Cytokines deficiency disease disease models dose drug Drug efficacy Drug screens effective Efficacy HCQ help High dose Hydroxychloroquine Intervention Lower respiratory tract malaria management Molecular biology Prophylaxis reduce respiratory Result rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 disease significantly therapeutic Therapeutics Treatment upper and lower respiratory tract use of hydroxychloroquine [DOI] 10.1172/jci.insight.143174 PMC 바로가기 [Article Type] Research Article
Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir코로나바이러스 SARS-CoV-2 표적화: 프로테아제 억제제 로피나비르, 리토나비르 및 넬피나비르의 작용 기전에 대한 컴퓨터 통찰력Article Published on 2020-12-012022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] atomic level Betacoronavirus Chinese health authorities Clinical use coronavirus coronavirus disease Coronavirus disease 2019 coronavirus SARS-CoV-2 crystallographic structure Drug discovery drugs effective endopeptidase Final health authorities HIV/AIDS In-vitro Infectious diseases information inhibitors lack Ligand Lopinavir LOPINAVIR AND RITONAVIR M pro mechanism of action Medicinal chemistry molecular molecular dynamics nelfinavir pathway protease Protease inhibitor provided Research respiratory Respiratory disease responsible Ritonavir RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease severe respiratory disease shown single-stranded starting targeting the SARS-CoV-2 therapeutic strategy Treatment Viral viral infection [DOI] 10.1038/s41598-020-77700-z PMC 바로가기 [Article Type] Article
Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro새로운 SARS-CoV-2 시험관 내 바이러스 프로테아제 억제제의 비교 항바이러스 효능Article Published on 2020-12-012022-09-11 Journal: Virologica Sinica [Category] SARS, 치료제, [키워드] (Lopinavir/ritonavir Analysis Antiviral antiviral efficacy best carried caused Clinical use Comparative compounds Concentration coronavirus Coronavirus infection Coronavirus pneumonia COVID-19 dosage effective evaluated experimental evidence Health Organization Human immunodeficiency virus identifying in silico in vitro in vivo information inhibitor inhibitory inhibitory effect Kaletra Lopinavir Lopinavir/ritonavir mechanism New coronavirus novel Novel coronavirus Novel coronavirus infection novel coronavirus pneumonia outbreak patients pharmacokinetics plasma concentration Pneumonia protease Protease inhibitor provided public health regimen Research respiratory Respiratory pharmacology Ritonavir Safe SARS-CoV-2 Solidarity trial suggested Support tablets targets tested Viral World Health Organization [DOI] 10.1007/s12250-020-00288-1 PMC 바로가기 [Article Type] Article
The dark side of the spoon – glucose, ketones and COVID-19: a possible role for ketogenic diet?Review Published on 2020-11-202022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] adverse outcome Anti-inflammatory Cardiovascular function Clinical outcome Clinical use Comorbidity complications COVID-19 COVID-19 disease Critical diabetes Effect effective Effects Fat mass Glucose health condition health-care system hyperglycaemia hypertension Immunity immunomodulating increase in Infection Inflammation ketogenic lean mass Metabolic rehabilitation novel coronavirus disease nutritional status obesity physiological plasma Prevent public health reduction risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection type 2 diabete VLCKD [DOI] 10.1186/s12967-020-02600-9 PMC 바로가기 [Article Type] Review