Critical – Page 17 – Communicable Diseases Research

PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu

Article

Published on 2022-09-082022-11-15
Journal: Frontiers in Immunology [Category] 바이오마커,

The impact of repeated rapid test strategies on the effectiveness of at-home antiviral treatments for SARS-CoV-2

Article

Published on 2022-09-082022-11-15
Journal: Nature Communications [Category] SARS, 치료제,

Impending disaster: rise of the epsilon variant in Pakistan and the way forward

Article

Published on 2022-09-072022-11-15
Journal: International health [Category] SARS, 변종, 유전자 메커니즘, 치료기술,

Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics Analysis

Article

Published on 2022-09-062022-11-15
Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커,

[키워드] acute respiratory disease Analysis AUC biological processes caused CD14 cellular components Coronavirus pneumonia COVID-19 COVID-19 patient Critical datasets deaths DEGs Diagnosis diagnostic value differentially expressed gene downregulated enrichment analysis expression function Gene ontology KEGG Kyoto limit majority moderate molecular function nonsurvivor novel novel coronavirus SARS-CoV-2 Pathway enrichment analysis PPI predict Prognosis protein-protein interaction screened secondary secondary bacterial infection selected severe COVID-19 severe COVID-19 patient severity significantly significantly higher significantly increased survivor Treatment upregulated utility was performed
[DOI] 10.1155/2022/9914927 PMC 바로가기

Immunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particles

Article

Published on 2022-09-052022-11-15
Journal: Journal of Nanobiotechnology [Category] SARS, 치료기술,

[키워드] Accuracy acute respiratory syndrome aluminum amplification analyses antibody applied Characteristics clinical sample coefficient Complete Complete virions conditions convalescent coronavirus coronavirus disease COVID-19 Critical detect diagnose facilitate Factor glycoprotein Human immunodeficiency virus human serum Immune escape Immunomolecular detection IMPROVE infection risk Influenza isolation rooms limit of detection molecular monoclonal antibody Mutation nucleic acid amplification Outbreaks parameters Patient pseudovirus quantified Quantitative reduced reverse transcription PCR reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 pseudovirus selective specific antibodies spike stability Vaccine Variation Viral load viral nucleic acid viral spike viral titer virion virions virus virus detection virus isolation viruses
[DOI] 10.1186/s12951-022-01558-8 PMC 바로가기

Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study

Article

Published on 2022-09-032022-11-15
Journal: BMC Infectious Diseases [Category] SARS, 진단,

[키워드] antibodies Asymptomatic Barcelona clinical Clinical spectrum Cohort COVID-19 COVID-19 pandemic criteria Critical determine Diagnosis disease disease severity Effect exceptional Factor Gender Health care health care workers healthcare healthcare worker healthy heterogeneous humoral immune response Humoral immunity IgG IgG and IgM IgM IgM and IgG immune response infected with SARS-CoV-2 interactions Kinetics kinetics of antibody large cohort Ministry of Health nine non-linear mixed model Non-linear mixed models nucleocapsid participant patients with asymptomatic positive provide public health Regional remained SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seroprevalence Significant study period the SARS-CoV-2 virus threshold understanding vaccination
[DOI] 10.1186/s12879-022-07696-6 PMC 바로가기

Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination

Article

Published on 2022-09-022022-11-16
Journal: Frontiers in Immunology [Category] SARS, 변종,

Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection

Article

Published on 2022-09-022022-11-16
Journal: PLoS Pathogens [Category] 유전자 메커니즘,

[키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization
[DOI] 10.1371/journal.ppat.1010809 PMC 바로가기

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking

Article

Published on 2022-09-022022-11-16
Journal: Human Genomics [Category] SARS, 변종,

[키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses
[DOI] 10.1186/s40246-022-00411-1 PMC 바로가기

Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic

Randomized Controlled Trial

Published on 2022-09-022022-10-05
Journal: Trials [Category] SARS, 임상,

[키워드] active site activity affected applied approaches assessment assessments Canada CONSORT COVID-19 pandemic creating Critical Critical care Critical illness Cycling data entry determine discharge Endpoint enrolled extremity Guidance ICU ICUs In-hospital intensive care unit International Intervention Lower management Modification outcomes pandemic Patient Patient care physical Primary outcome Primary outcomes protocol provide Randomized Randomized controlled trial Randomized controlled trials randomized trial RCT receiving recruitment rehabilitation required Research Research design Research personnel Research report. retained risk strength Trial
[DOI] 10.1186/s13063-022-06640-y PMC 바로가기 [Article Type] Randomized Controlled Trial