Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States
미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크
Research Article
[키워드] activity
African Americans
alterations
American
Americans
Amino acid
amino acid metabolism
amino acids
biological processe
biological processes
branched-chain amino acids
cardiovascular
cardiovascular disease
cardiovascular diseases
cause
causes
CAV1
Cell culture
co-expression
Cohort
commonality
complex disease
connection
Critical
CVD
data-driven
death
diabetes
disease
Diseases
Diversity
driven by
driver
ENCODE
Epidemics
eQTLs
expression
expression quantitative trait loci
Extracellular matrix
finding
FIVE
functional
Functional genomics
gene knockout
gene network
gene networks
Genetic
genetic risk
Genome-wide association study
Glucose
graphical models
GWAS
GWAS hit
help
Hispanic
HMGCR
human population
human populations
hybrid
identify
IGF1
immune response
in vitro
in vivo
information
Integrative analysis
knockdown
lipids
loci
mechanism
metabolism
molecular
molecular network
mouse
Mouse models
multidimensional
multiple tissues
network models
neuronal
offer
overlapping
Panel
Pathogenesis
pathogenic
pathogenic processe
pathway
Pathways
PCOLCE
Population
populations
Quantitative
Regulatory
regulatory network
Risk factors
shared pathway
shared pathways
siRNA
Strains
Support
T2D
the United State
therapeutic
therapeutic target
tissues
type 2 diabete
type 2 diabetes
[DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article