D614G – Page 17 – Communicable Diseases Research

A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology

다중 PCR-질량 분석 미니시퀀싱 기술을 기반으로 하는 SARS-CoV-2 변이체 감지를 위한 새로운 전략

Research Article

Published on 2021-11-172022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술,

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms

Curcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다

Article

Published on 2021-11-162022-09-10
Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used
[DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article

Evolutionary and Antigenic Profiling of the Tendentious D614G Mutation of SARS-CoV-2 in Gujarat, India

Genetics

Published on 2021-11-112022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

SARS-COV-2 불활성 백신에 의해 유도 된 항체 및 T 세포에 의한 관심의 변이체 인식

Clinical Trial

Published on 2021-11-092022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha antibodies antibody approved B.1.1.7 B.1.351 Beta Beta variant binding cellular response Cellular responses Chilean circulating variant clinical trial concern CoronaVac coronavirus D614G death rate Delta delta variant described detect dose elicited ELISPOT enrolled evaluate evaluated Gamma genetic difference genetic differences geometric mean Geometric means house human ACE2 receptor immune response immunization immunization schedule immunization schedules immunized immunogenic in-house ELISA inactivated induced Infection interferon interferon-γ-secreting T cell interferon-γ-secreting T cells Lineage microneutralization neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing capacity P.1 pandemic PBMC PBMCs Phase 3 phase 3 clinical trial promote Protective RBD Receptor binding domain Recognition reduced respiratory responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secreted secretion Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significant differences spike stimulate subject T cell immunity T cells tested the RBD the SARS-CoV-2 the vaccine titers Vaccine variant variants variants of concern virus Volunteer volunteers were used Wuhan Wuhan, China
[DOI] 10.3389/fimmu.2021.747830 PMC 바로가기 [Article Type] Clinical Trial

Implication of SARS-CoV-2 Immune Escape Spike Variants on Secondary and Vaccine Breakthrough Infections

2차 및 백신 돌발 감염에 대한 SARS-CoV-2 면역 탈출 스파이크 변이의 의미

Review

Published on 2021-11-032022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Breakthrough infection coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine D614G deaths disease E484K Efficacy escape etiological agent facilitate Genome Health highlight Immune escape immune evasion L452R mechanism Modification Mutation N501Y new SARS-CoV-2 promote Public health response Re-infection respiratory SARS-CoV-2 SARS-CoV-2 variants secondary Secondary infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein therapeutic Vaccine variant variants Viral viral spike protein
[DOI] 10.3389/fimmu.2021.742167 PMC 바로가기 [Article Type] Review

Genomic diversity of SARS-CoV-2 in Malaysia

Bioinformatics

Published on 2021-11-032022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] A701V accumulated Algorithm analysed analyses approved Asian association circulating Clustering complexes Consequences Continuous country COVID-19 pandemic D614G distribution Emergency use epidemiological examined Genes Genetic genetic change genetic diversity Genome genomic GISAID Health help immune evasion isolate Lineage lineages Linkage disequilibrium Malaysia massive minimum Mutation mutations new SARS-CoV-2 Non-synonymous nucleotide substitution ORF1ab performed populations Public ranged researchers Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus sequence sequenced Seven Spread Surveillance tree Vaccine variant viral genome Viral genome sequencing viral nucleotide virus
[DOI] 10.7717/peerj.12449 PMC 바로가기 [Article Type] Bioinformatics

Insights on the SARS-CoV-2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics

SARS-CoV-2 게놈 다양성에 대한 통찰력: 브라질에서 배운 교훈과 전염병의 미래에 미치는 영향

Outbreak Reports

Published on 2021-11-032022-09-10
Journal: Microbial Genomics [Category] MERS, SARS, 변종,

[키워드] Affect affected alteration analysed Brazil change circulating conformational contributed countryside COVID-19 COVID-19 pandemic D614G described dynamic Epidemiology expected explained genomic sequence analysis Impact Infection insight measure Mutation N protein P.2 variant pandemic Pandemics Phylogenetic analysis Positive selection regions replaced SARS-CoV-2 SARS-CoV-2 genome sequences SARS-CoV-2 strain SARS-CoV-2 strains social isolation Spread the N protein the SARS-CoV-2 the SARS-CoV-2 genome UTR UTRs Variability variant variants variants of concern variants of interest Viral viral genome
[DOI] 10.1099/mgen.0.000656 PMC 바로가기 [Article Type] Outbreak Reports

Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing

코로나바이러스 질병 2019(COVID-19) 계통발생학적으로 뚜렷한 중증 급성 호흡기 증후군에 의한 재감염 전체 게놈 시퀀싱으로 확인된 코로나바이러스 2 균주

Article

Published on 2021-11-022022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단,

[키워드] acute infection Amino acid amino acids Analysis analyzed asymptomatic infection C-reactive protein collected Comparative conducted Confirmed by coronavirus 2 COVID-19 D614G elevated Evidence Genome genomic GISAID Human IgG Immunity immunological Infection natural infection nucleotide occur occurred ORF8 Patient phylogenetically Protective Proteins Re-infection respiratory respiratory specimen RT-PCR Ct SARS-CoV-2 SARS-CoV-2 IgG Sequencing Seroconversion serological serum stop codon strain symptomatic T cell epitopes the patient Vaccine design viral genome viral shedding virus virus genome was performed whole genome Whole genome sequencing
[DOI] 10.1093/cid/ciaa1275 PMC 바로가기 [Article Type] Article

Macrophages and Monocytes: “Trojan Horses” in COVID-19

Article

Published on 2021-10-282022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa

상세한 계통발생학적 분석은 중국과 유럽에서 서아프리카로의 뚜렷한 SARS-COV-2 변이체의 전파를 추적합니다.

Article

Published on 2021-10-262022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종,