epithelial cell – Page 17 – Communicable Diseases Research

SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction

Virus-Cell Interactions

Published on 2021-02-262022-10-30
Journal: Journal of Virology [Category] COVID-19,

Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 Virus

Article

Published on 2021-02-242022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] 1:1 3CL 3CL Protease Acetate activity acute respiratory syndrome addition Antiviral binding affinity carried cause cellular characterization China Clinical efficacy clinical study complex component Concentration coronavirus Coronavirus replication COVID COVID-19 COVID-19 pandemic criteria docking Efficacy epithelial cell evaluate factorial design Factors FDA-approved drugs Glatiramer acetate half-maximal inhibitory concentration Health IC50 investigated Nanoparticles outbreak Prevent protease protease inhibition required responses SARS-CoV-2 selected shown sitagliptin target cell TEM the SARS-CoV-2 virus transmission electron microscopy treat VERO-E6 virus were assessed
[DOI] 10.3390/ph14030178 PMC 바로가기 [Article Type] Article

A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL pro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19

Vaccines and Antiviral Agents

Published on 2021-02-232022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] 3CL pro A549 ACE2 acute respiratory syndrome airway airway epithelium alveolar Analysis Antiviral Antiviral compound antiviral drug approach approved Cell cells clades clinical trials Comparative complex component concentrations coronavirus coronavirus disease COVID-19 cultures develop direct-acting drug candidate effective Efficacy epithelial epithelial cell etiological agent Evidence experiment Express GC-376 Human airway epithelium human airway epithelium cultures in vitro in vitro model inhibit SARS-CoV-2 inhibitor kidney M pro New P-glycoprotein polymerase polyprotein Potential protease provide regimen Remdesivir SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 protease Side effect suggested targets the SARS-CoV-2 the timing time-of-addition experiments treat VERO E6 cells viral life cycle
[DOI] 10.1128/JVI.01819-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19

Life Sciences–Mathematics interface

Published on 2021-02-172022-10-30
Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS,

[키워드] acting acute respiratory distress anti-inflammatory agent Asymptomatic carrier biochemical blockade Clinical deterioration Corticosteroids COVID-19 COVID-19 illness current Cytokine storm develop epithelial cell Evidence FIVE hyperinflammation Hyperinflammatory hyperinflammatory state increasingly individual Inflammation Inflammatory response Inhaled inhaled corticosteroids Intervention involved lung mathematical Mild moderate pathological mechanism pathway Patient physiological Prevent pro-inflammatory mediator respiratory compromise SARS-COV-2 infection sensitivity analysis severe COVID-19 disease severe disease Simulation supported syndrome therapeutic intervention trajectory virus while
[DOI] 10.1098/rsif.2020.0950 PMC 바로가기 [Article Type] Life Sciences–Mathematics interface

Molecular recognition in the infection, replication, and transmission of COVID-19-causing SARS-CoV-2: an emerging interface of infectious disease, biological chemistry, and nanoscience

Reviews

Published on 2021-02-052022-10-05
Journal: NPG Asia Materials [Category] 변종, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome adaptive addition angiotensin-converting enzyme 2 Antiviral binding coronavirus coronavirus disease CoV CoV infection COVID-19 CoVs develop epithelial cell form function Genome glycans Host host cell Human IFN IFNs immune response Immunity immunology infected with SARS-CoV-2 Infection Infectious disease interferon involved macaque mechanism Medicine mutated Mutation N-acetylneuraminic acid nuclear outbreak pandemic Pandemics pathway physician platform progeny virion protease Protein receptor Replication researchers RNA SARS-CoV SARS-CoV-2 secretion serine 2 severity SGP sialic acid specificity spike glycoprotein stimulate Structure Symptom the cytokine storm the SARS-CoV-2 Toll-like receptor Transcription transmembrane Transmission Vaccine virus Wuhan
[DOI] 10.1038/s41427-020-00275-8 [Article Type] Reviews

Comparison of Antiviral Activity of Gemcitabine with 2′-Fluoro-2′-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2

SARS-CoV-2에 대한 젬시타빈과 2'-플루오로-2'-데옥시시티딘 및 렘데시비르 병용 요법의 항바이러스 활성 비교

Comparative Study

Published on 2021-02-042022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 치료제,

[키워드] 2′-fluoro-2′-deoxycytidine 50% effective concentration activity acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral activity antiviral assay Antiviral assays antiviral drugs approved blocked Calu Calu-3 causative agent Chain Reaction clinically Combination compounds Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytotoxicity deoxycytidine dose-dependent manner epithelial cell epithelial cells evaluated expression gemcitabine human lung human lung epithelial cells human-to-human transmission in vitro infected cells monophosphate pandemic polymerase chain polymerase chain reaction Quantitative Remdesivir respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spread synergistic synergistic effect treat Vero CCL-81 cell Vero CCL-81 cells Viral Viral protein virus virus-infected cells western blot
[DOI] 10.3390/ijms22041581 PMC 바로가기 [Article Type] Comparative Study

Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study

Research

Published on 2021-02-042022-10-05
Journal: Molecular Psychiatry [Category] SARS, 임상, 진단, 치료제,

[키워드] 95% CI adjusted adults hospitalized Analysis Antiviral effect AP-HP association biological marker Characteristics conducted COVID-19 Cox model death depressive disease severity disorder Endpoint epithelial cell examined Hospital admission hospitalized patient hospitals In-vitro Infection inhibit intubation lower risk medication Meta-analysis multicenter multiple sensitivity analyses multivariable Paris Patient patients hospitalized plasma Prevent primary analysis primary endpoint pro-inflammatory mediators Probability psychotropic medications randomized clinical trial recent reduced reduced risk remained retrospective cohort study SARS-CoV-2 severe COVID-19 university Weighting
[DOI] 10.1038/s41380-021-01021-4 [Article Type] Research

Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease

숙주 스핑고지질: COVID-19 질병 관리를 위한 SARS-CoV-2 감염 제어를 위한 관점 면역 보조제

Review

Published on 2021-02-012022-09-11
Journal: Prostaglandins & other lipid mediators [Category] SARS, 신약개발, 치료제,

[키워드] Activation Antigen presentation Antiviral approach autophagy Bacterial infections ceramide clearance COVID 19 COVID-19 cases COVID-19 disease COVID-19 infection COVID-19 patients derivative effector immune response enzyme II epithelial cell epithelial cells expected Features fibrosis fingolimod FTY720 Host host-pathogen interactions human diseases hyper-inflammatory response Hyper-inflammatory responses IL-6 immune Immune adjuvants immune responses immunosuppressive Infection involved Lipid Lyase M1/M2 macrophages macrophages membrane-bound modulate Pathogenesis pathological outcomes pathological response phosphate promote receptor Replication respiratory SARS-CoV-2 SARS-COV-2 infection Signaling sphingolipid sphingolipids sphingosine-1-phosphate symptomatic T cell T cell response Th1 Th1 effector response.
[DOI] 10.1016/j.prostaglandins.2020.106504 PMC 바로가기 [Article Type] Review

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

흡입 코르티코스테로이드는 I형 인터페론의 억제를 통해 COPD에서 SARS-CoV-2 수용체 ACE2를 하향 조절합니다

Covid-19

Published on 2021-02-012022-09-10
Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Abstract ACE2 ACE2 expression ACE2, Angiotensin-converting enzyme-2 administration airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 BEC, Bronchial epithelial cell BSG, Basigin Cell culture changes chronic obstructive chronic obstructive pulmonary disease contribute COPD COPD, Chronic obstructive pulmonary disease coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 in patient COVID-19, Coronavirus disease 2019 disease downregulate Elastase entry receptor epithelial epithelial cell evaluate the effect evaluated exogenous IFN expression FP, Fluticasone propionate functional GR, Glucocorticoid receptor group human airway human airway epithelial ICS ICS therapy ICS, Inhaled corticosteroid ICSs IFN-α/β IFN-β IFNAR1 Inhaled inhaled corticosteroid inhaled corticosteroids interferon signaling ISG, Interferon-stimulated gene mechanism mice mouse model Mouse models objective obstructive pulmonary disease Patient PROTECT pulmonary disease receptor receptor ACE2 reduce expression reduced Result reversed risk SARS-CoV-2 entry receptor severe coronavirus disease severe COVID-19 sputum stratified susceptibility the SARS-CoV-2 therapy TMPRSS2, Transmembrane serine protease 2 type I type I interferon Viral viral entry viral infection were used
[DOI] 10.1016/j.jaci.2020.09.034 PMC 바로가기 [Article Type] Covid-19

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

1차 인간 기도 상피에서 SARS-CoV-2 향성의 단일 세포 분해능, 항바이러스 반응 및 요법에 대한 감수성

Research Article

Published on 2021-01-282022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, 치료제,

[키워드] airway epithelial cells airway epithelium Antiviral antiviral immunity antiviral responses antiviral therapies antiviral therapy array blocked Cell cell population cell type cell types cellular ciliated cell ciliated cells Ciliated epithelial cells contribute COVID-19 pathogenesis dominant element elements epithelial cell epithelial cell type epithelial cell types epithelial cells expressed Factor flow cytometry gene signatures heterogeneity heterogenous host protease host protease TMPRSS2 Human airway epithelium hyperinflammatory responses IL-6 induction infect infected cell infected cells Infection inhibited initial interferon interferon response ISG ISGs mediator outcome Pathogenesis predominant primary human airway Remdesivir required respiratory respiratory tract RNA-sequencing SARS-CoV-2 SARS-COV-2 infection secretory cell secretory cells Single Cell susceptibility susceptible therapy These cells TMPRSS2 Treatment Treatment response variety Viral viral replication viral tropism
[DOI] 10.1371/journal.ppat.1009292 PMC 바로가기 [Article Type] Research Article