Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable EpitopesSARS-CoV-2 스파이크 단백질의 구조 역학: SARS-CoV-2 변이체(알파에서 오미크론까지)의 2년 후향적 분석을 통해 보존된 에피토프와 가변 에피토프 간의 초기 차이가 드러났습니다.Article Published on 2022-06-152022-09-11 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 binding ADE analyzed antibodies antibody Antibody-dependent enhancement antiviral strategy approaches bind binding circulating conformational change conserved COVID-19 infection D614G D614G mutation Delta determined by Divergence domain Dynamics epitope Epitopes Evolution facilitate facilitating antibodies flat help host cells linear mimicking molecular Molecular epidemiology Mutation N-terminal domain Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron pandemic Retrospective analysis risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 variants selected spike Spike protein the SARS-CoV-2 the spike protein Vaccine Variability variable was determined [DOI] 10.3390/molecules27123851 PMC 바로가기 [Article Type] Article
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins기억 B 세포의 분석은 변이체 SARS-Cov-2 스파이크 단백질의 N-말단 도메인에서 보존된 중화 에피토프를 식별합니다Article Published on 2022-06-142022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-NTD neutralizing antibodies. antibodies antibody capture Cell class clinical outcomes Cohort conserved contribute Course domain epitope Epitopes Gamma group identify infected individuals Infection memory B cell memory B cells N-terminal domain neutralized Neutralizing Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses neutralizing epitope NTD omicron plasma Plasma cell probe producing Rapid RBD Re-infection Receptor-binding domain recruitment SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants Spike protein spike trimer Subsequent infection subsequent infections target targeted epitope vaccination variant [DOI] 10.1016/j.immuni.2022.04.003 PMC 바로가기 [Article Type] Article
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles널리 알려진 교차 반응성 SARS-CoV-2 CD4 T 세포 에피토프는 인간 코로나바이러스 전반에 걸쳐 고도로 보존되어 있으며 일반적인 HLA 대립유전자에 의해 제시됩니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect animal coronavirus binding CD4 CD4 T cell CD4 T cells common-cold conserved Contact convalescent COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity Donor donors driven by epitope explained fusion peptide Heterologous heterologous immunity highlight HLA allele homology human coronavirus human populations Infection major histocompatibility complex memory response MHC class mRNA vaccine overlapping preference Protein proximal raise recipients residue SARS-CoV-2 SARS-CoV-2 sequence seasonal coronavirus spike fusion peptide proximal region. Substitution T cell T cell epitope T cell receptor T cell receptor repertoire T cell response TCR TCR sequencing TCRs uninfected [DOI] 10.1016/j.celrep.2022.110952 PMC 바로가기 [Article Type] Article
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccineesCOVID-19 mRNA 백신에 있는 Omicron BA.1 및 BA.2 중화 항체의 해부학Article Published on 2022-06-132022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered antibody BNT162b2 BNT162b2 mRNA vaccine class conserved COVID-19 COVID-19 pandemic cross-neutralize cross-neutralizing antibodies cross-neutralizing antibody cross-protection Donor Effect elicited epitope Epitopes Evidence germlines IGHV1-58 IGHV1-69 IGHV2-5 mitigate molecular molecular basis mRNA mRNA vaccine NAb NAbs neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody not neutralize NTD omicron other coronaviruses predominant question RBD Receptor binding domain recognize Region S protein SARS-CoV-1 SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccines seronegative seropositive Spike protein tested the S protein the SARS-CoV-2 vaccination Vaccine design vaccinee Vaccines variants variety virus Wuhan [DOI] 10.1038/s41467-022-31115-8 PMC 바로가기 [Article Type] Article
High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] abrogate Altered Analysis anti-CD20 anti-CD20 therapy anti-CD20 therapy. B-cell CD39 CD4 CD4+ CD4+ T-cells CD45 CD45RA CD73 Cell circulating COVID-19 CRP CXCR5 effector cells epitope Ex vivo expression follicular Frequency help helper cell IL-6 Infection inflammation marker Interaction lack LAG-3 membrane protein memory MHC class MHC class II MHC class II Tetramer Patient patients PD-1 phenotype Prolonged receptor reduced robust SARS-CoV-2 skewed T follicular helper cell T-cell T-cell memory T-cell Response T-cells tetramer the patient TIGIT viral replication [DOI] 10.3390/v14061265 PMC 바로가기 [Article Type] Article
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategyDNA 프라임-단백질 부스트 전략을 이용한 SARS-CoV-2 변이체 감염에 대한 고친화성 단일클론항체 유도Article Published on 2022-06-092022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha alpha and delta variants angiotensin angiotensin-converting enzyme 2 animals Antibody titers approach approved best Beta Beta variant binding ability binding affinity boost broad spectrum clone coronavirus Coverage COVID-19 COVID-19 vaccination D614G Delta delta variant DNA ELISA Emergency use Endemic epitope epitope mapping Epitopes evaluated exhibit flu Gamma generate high affinity Human angiotensin-converting enzyme 2 include induction Infection Lambda monoclonal antibodies monoclonal antibody monoclonal antibody combination Multiple neutralization neutralization potency neutralize Neutralizing antibody titer neutralizing capacity neutralizing epitope neutralizing epitopes Outbreaks PROTECT RBD Receptor-binding domain regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Spike protein the receptor-binding domain the spike protein therapeutic drug therapeutic effect therapeutic effects treat treated Treatment variant variants VoC VOCs were used Wuhan strain [DOI] 10.1186/s12929-022-00823-0 PMC 바로가기 [Article Type] Article
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope35B5 항체는 보존된 스파이크 에피토프를 통해 N-글리칸 스위치를 방해하여 SARS-CoV-2 Omicron을 강력하게 중화합니다.Article Published on 2022-06-082022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 35B5 ACE2 antibody antigenic antigenic shift change changes conformational change conserved Control cryo Cryo-electron microscopy disrupting dissociation domain Efficacy electron microscopy entry receptor epitope exhibit Extracellular Fab glycan Host immune evasion Microscopy monoclonal monoclonal antibody Mutation N-terminal domain neutralization neutralize Neutralizing Neutralizing antibodies neutralizing capacity not affect NTD omicron other variant other variants RBD Receptor-binding domain Recognition SARS-CoV-2 Spike protein Structure the RBD the spike protein therapeutic transition trimer trimeric variant [DOI] 10.1016/j.chom.2022.03.035 PMC 바로가기 [Article Type] Article
Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics치료제로서의 최적 기능을 위한 Anti-SARS-CoV-2 단일클론항체 변형 전략 평가Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alleviate antibody Antibody-dependent enhancement caused Cell circulating closure Combination coronavirus country COVID-19 infection COVID-19 infections COVID-19 pandemic death disease Economy Effect epitope Epitopes Health crisis Human human population humoral immune response in vitro infecting investigated LALA lockdown mAb mAbs modify monoclonal antibodies monoclonal antibody Mutation neutralize produced public health crisis public health measure public health measures reduce reported respiratory resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 spike protein serum severe acute respiratory syndrome Coronavirus Spike protein Spread the antibody the disease the spike protein therapeutic option therapy These data Viral viral variant virus writing [DOI] 10.1371/journal.pone.0267796 PMC 바로가기 [Article Type] Article
Structural diversity of the SARS-CoV-2 Omicron spikeSARS-CoV-2 오미크론 스파이크의 구조적 다양성Article Published on 2022-06-022022-09-11 Journal: Molecular Cell [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Analysis changes in communication conformational conformational change Critical cryo Cryo-electron microscopy cryo-EM structure cryo-EM structures Crystallography Delta delta variant determine domain dominant electron microscopy epitope fusion peptide immune immune evasion Impact interprotomer communication intraprotomer communication Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron spike peptide RBD Receptor-binding domain SARS-CoV-2 evolution spike Spike protein the SARS-CoV-2 Transmissibility variant vector analysis. virus transmissibility X-ray X-ray crystallography [DOI] 10.1016/j.molcel.2022.03.028 PMC 바로가기 [Article Type] Article
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses Research Published on 2022-06-022022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome antibody binding breadth conserved coronavirus coronavirus vaccine development Donor effective Efficacy epitope exhibited Health Human in vivo Isolation mitigate molecular basis Neutralizing neutralizing antibody omicron Prophylactic Prophylaxis Protective RBD sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-like coronavirus SARS-like virus the receptor-binding domain therapeutic threat Vaccines variant variants of concern VOCs [DOI] 10.1038/s41590-022-01222-1 [Article Type] Research