Single primer isothermal amplification (SPIA) combined with next generation sequencing provides complete bovine coronavirus genome coverage and higher sequence depth compared to sequence-independent single primer amplification (SISPA)Research Article Published on 2017-11-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] amplification approach approach bovine Bovine coronavirus characterisation Complete Coverage data sets Efficiency expected full-length full-length genome generate Genome genome coverage Genome sequencing Health isothermal amplification mapped MERS nasal swab novel coronavirus primer produced provide quasispecy reference genome sequence Sequencing viral genome analysis Viral RNA virus virus while [DOI] 10.1371/journal.pone.0187780 PMC 바로가기 [Article Type] Research Article
Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated regionOriginal Article Published on 2017-06-212022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] 5′-untranslated region addition Analysis Asia Asian China collected coronavirus coronavirus genomes Diagnosis epidemiological studies Fecal sample genome sequence Genome sequencing Hong Kong indels Infection infections involved Molecular epidemiology nasopharyngeal nasopharyngeal sample North America outbreak Outbreaks over pig polymorphic site positive provide quasispecy respiratory infection respiratory route respiratory sample respiratory tract Sample Spread strain substitutions tested the United State Transmission virus [DOI] 10.1038/emi.2017.37 PMC 바로가기 [Article Type] Original Article
Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis곰팡이 약물 내성 및 형태 형성을 제어하는 세포 회로를 조사하기 위한 강력한 전략으로서의 금속 킬레이트화Research Article Published on 2016-10-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation Affect analysis Antifungal approach approaches Candida albican Candida albicans candidiasis caspofungin cell wall Cellular responses chelation Combination Compound demonstrated depleting Depletion drug drug resistance DTPA echinocandin effective Efficacy ENhance environmental cues fungal fungal cell wall Fungal infection fungal infections fungal pathogens gene encoding Genome sequencing Health histidine homeostasis identify increase Infectious disease inhibitor invasive lead library life-threatening Magnesium mechanism metal mitogen mitogen-activated protein kinase modulate morphogenesis mouse model murine model mutant mutants Mutation pathogen Pathogenesis Pathogens pathway Protein protein kinase reduce regulated resistance screened Sequencing Signaling Strategy Stress stress response susceptibility synergistic therapeutic Therapeutic benefit therapeutic benefits therapeutic potential therapeutic strategy Therapeutics transcription factor transcription factors upstream virulence Whole genome sequencing Zinc [DOI] 10.1371/journal.pgen.1006350 PMC 바로가기 [Article Type] Research Article
Genotyping Influenza Virus by Next-Generation Deep Sequencing in Clinical SpecimensArticle Published on 2016-05-232023-06-23 Journal: Annals of laboratory medicine [Category] 신종인플루엔자, [키워드] Genome sequencing Influenza virus Next-generation sequencing nosocomial outbreak pandemic H1N1 virus [DOI] 10.3343/alm.2016.36.3.255 PMC 바로가기
Characterization and analysis of an infectious bronchitis virus strain isolated from southern China in 2013Research Published on 2016-03-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Affect Analysis bronchitis caused characterization China Complete Evolution Genes Genome Genome sequencing highest IBV identity indicated Infectious Bronchitis Virus insertion involved mechanism Mutation parental performed Phylogenetic analysis Prevalence Recombination Result Sequence analysis severe disease strain Strains subgroups Taiwan the disease vaccine strain Variation [DOI] 10.1186/s12985-016-0497-3 PMC 바로가기 [Article Type] Research
Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015Dispatch Published on 2016-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] adaptive changes in coronavirus Evidence Evolutionary rate Genome sequencing Infection MERS-CoV microevolution Middle East Middle East respiratory syndrome outbreak Patient Phylogenetic analysis respiratory respiratory infections respiratory syndrome coronavirus sequenced South Korea strain Transmission viral genome Viral proteins viruses [DOI] 10.3201/eid2202.151700 PMC 바로가기 [Article Type] Dispatch
Full-Genome Sequence of Influenza A(H5N8) Virus in Poultry Linked to Sequences of Strains from Asia, the Netherlands, 2014Article Published on 2015-05-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Asian strains Genome sequencing H5N8 Influenza poultry The Netherlands viruses [DOI] 10.3201/eid2105.141839 PMC 바로가기
An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titrationResearch Article Published on 2015-03-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Administered caused Cell culture Complete Culture demonstrated diarrhea disease dose Efficacy ELISA enzyme-linked immunosorbent Epidemic epidemic diarrhea evaluate experimental design FIVE fluorescent foci Genome sequencing help highly pathogenic humoral immune response identity immunoassay immunogenic immunogenicity inactivated Inactivated vaccine infective intramuscularly log microsphere monovalent vaccine negative controls Neutralization assay nucleotide PEDV performed pig Porcine Protective responses Result selected sera significantly higher strain TCID tissue vaccinate Vaccine vaccine candidate virus [DOI] 10.1186/s12917-015-0357-1 PMC 바로가기 [Article Type] Research Article
Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes폐렴구균 모자이크 유전자 내 베타-락탐 내성과 관련된 단일 뉴클레오티드 다형성의 포괄적인 식별Research Article Published on 2014-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alterations Amino acid analysed antibiotic Antibiotic resistance Antibiotic treatment Antibiotics approach arise association Bacteria Beta-lactam beta-lactam antibiotics block blocks carried cause change children clinical setting collected Comprehensive description determinant determinants Diseases distribution DNA fragment explain Frequency Genetic genetic association genetic determinant genetic determinants Genome Genome sequencing Genome-wide association study genomes Haplotype identification identify INDEL indels independent dataset independent datasets introduced isolate isolates large sample leads lineages loci mechanism Meningitis morbidity morbidity and mortality more difficult mosaic Mutation nasopharyngeal non-susceptibility nucleotide organism performed pneumococcal Pneumonia pneumoniae populations predict Previous studies previous study raise Recombination reported resistance responsible sensitivity sequence single nucleotide Single nucleotide polymorphism single nucleotide polymorphisms SNPs Spread strain Strains Streptococcus pneumoniae susceptible Traditional Treatment understanding USA variant variants while [DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article
Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human BetacoronavirusExpedited Published on 2013-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis bat coronavirus Betacoronavirus circulating Complication computer-aided design Coronavirus infections country deep disease transmission European events Evolution genome sequence Genome sequencing High-throughput nucleotide sequencing Human human infection infectious Middle East molecular novel novel Betacoronavirus Patient Phylogenetic analysis renal Respiratory tract infections Sequencing specimen sputum Vespertilionidae viral variant virus virus genome viruses zoonoses zoonotic [DOI] 10.3201/eid1905.130057 PMC 바로가기 [Article Type] Expedited