healthy individuals – Page 17 – Communicable Diseases Research

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis

SARS-CoV-2 치료 또는 화학 예방에서 nitazoxanide 용도 변경을 위한 용량 예측

Original Article

Published on 2020-12-012022-08-31
Journal: British Journal of Clinical Pharmacology [Category] MERS, 신약개발, 진단, 치료제,

Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19

성장 분화 인자 15는 COVID-19로 입원한 선택되지 않은 환자에서 확립된 심혈관 및 염증성 바이오마커보다 우수한 예후 정보를 제공합니다

Article

Published on 2020-12-012022-08-31
Journal: Circulation [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Admission age association Atrial fibrillation baseline Biobank Biomarkers body mass body mass index C-reactive protein cardiac troponin cardiac troponin T cardiovascular cardiovascular disease collected Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 CVD D-dimer death detectable diabetes differentiation elevated enrolled estimated glomerular filtration rate Factor ferritin filtration rate glomerular filtration rate greater growth growth differentiation factor 15 healthy individuals heart failure Hospitalization hospitalized patient hospitalized patients Hypoxemia increase Infection Infectious disease inflammatory biomarkers intensive care intensive care unit interleukin interleukin-6 laboratory-confirmed lower oxygen saturation majority median Myocardial infarction N-terminal N-terminal pro-B-type natriuretic peptide Older outcome oxygen Patient patients hospitalized peptide primary end point pro-B-type natriuretic peptide procalcitonin prognostic Prognostic marker Prognostic value reached Registration respiratory risk SARS-CoV-2 score Sepsis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Sex Superior symptoms of COVID-19 troponin T Viremia with COVID-19
[DOI] 10.1161/CIRCULATIONAHA.120.050360 PMC 바로가기 [Article Type] Article

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

COVID-19 심각도는 CD1c+ DC 및 염증성 이행 및 비고전 단핵구의 폐 재분포와 관련이 있습니다.

Clinical Trial

Published on 2020-12-012022-08-31
Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome addition Antiviral ARDS association Blood CD1c CD8+ T cell CD8+ T cells characterized Clinical severity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity critical COVID-19 patients dendritic cell dendritic cells disease dysregulated immune response dysregulated immune responses frequencies Frequency healthy individuals immune responses immunology increase infected individuals Inflammation Inflammatory involved knowledge life-threatening lung lung infiltrate lung infiltrates Lungs Mild symptom mild symptoms monocyte Monocytes myeloid cell occur Pathogenesis pathogenesis of COVID-19 Patient profile progression respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 subpopulation subset syndrome T cell T cells Therapeutic strategies therapeutic strategy Viral viral control
[DOI] 10.1172/JCI140335 PMC 바로가기 [Article Type] Clinical Trial

Soluble Receptor for Advanced Glycation End Products and Its Forms in COVID-19 Patients with and without Diabetes Mellitus: A Pilot Study on Their Role as Disease Biomarkers

Article

Published on 2020-11-232022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

COVID-19로 입원한 환자의 혈청 내 전혈성 자가항체

Research Article

Published on 2020-11-182022-09-10
Journal: Science Translational Medicine [Category] 진단, 치료제,

[키워드] accelerated activated neutrophil Activation antibodies antibody antibody level antibody levels antiphospholipid antibodies autoantibodies autoantibody Autoimmune diseases blood vessel blood vessels Case series Casting circulating Coagulation coagulation pathway COVID-19 COVID-19 patient serum Cutoff develop eight ELISA FIBRIN filtration rate fraction glomerular filtration rate glycoprotein healthy individuals high risk Histopathology hyperactivity IgG IgG and IgM IgM in vitro injected injection Lung histopathology Lupus mice Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Occlusion pathogenic pathogenic autoantibodies pathogenic autoantibody pathway Patient patients patients hospitalized patients with COVID-19 phenotype phospholipid Phospholipids Platelet platelet counts positive potential therapeutic target potentially life-threatening promoted Protein prothrombin prothrombotic purified respiratory Respiratory disease reveal serum serum sample serum samples severe COVID-19 severe respiratory disease small blood vessel small blood vessels syndrome the disease threshold Thrombophilia thrombosis thrombotic venous Venous thrombosis with COVID-19
[DOI] 10.1126/scitranslmed.abd3876 PMC 바로가기 [Article Type] Research Article

Increased IL‐10‐producing regulatory T cells are characteristic of severe cases of COVID‐19

Original Article

Published on 2020-11-132022-10-31
Journal: Clinical & Translational Immunology [Category] COVID-19,

[키워드] Activation affected analysed Asymptomatic carriers characteristic clinical Community contribute coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 healthy individuals host–virus interaction Hypothesis identify IL‐10 immune response immunological immunology increase in Increased investigated Lineage lung lymphopenia New coronavirus objective open resource pandemic Patient patients Peripheral blood phenotype platform proportion Regulatory T cell regulatory T cells Research resource Result SARS‐CoV‐2 SARS‐CoV‐2 Severe case Spread systems immunology T regulatory cells T‐cell underlie Variation
[DOI] 10.1002/cti2.1204 PMC 바로가기 [Article Type] Original Article

Impact of coronavirus disease 2019 (COVID-19) pandemic on attitude, behavior, and mental health of patients with rheumatic diseases

Research

Published on 2020-11-122022-10-31
Journal: Egyptian Rheumatology and Rehabilitation [Category] COVID-19,

[키워드] addressed age Anxiety Attitude Behavior both group case-control study collected Community comparable composed Contact control group controls coronavirus disease COVID 19 COVID-19 COVID19 defined Depression distress forms Google group Health healthy healthy individuals Impact Infectious disease Insomnia irritability less medication mental health pandemic Panic participant Patient patients physician populations professionals PROTECT Psychiatric Psychological psychological pressure psychological problem psychological support questionnaire Result rheumatic disease Rheumatic diseases Rheumatic patients scale significantly significantly higher SLE SLE patient statistically significant difference Support Symptom systemic total score was measured washing hands wearing mask
[DOI] 10.1186/s43166-020-00045-y PMC 바로가기 [Article Type] Research

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses
[DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

생명을 위협하는 COVID-19 환자에서 I형 IFN 면역의 선천적 오류

Research Article

Published on 2020-10-232022-08-13
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘,

[키워드] a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect affecting age amplification amplification pathway Asymptomatic autoantibodies autoantibody autoantibody system autosomal-dominant autosomal-recessive Beck biochemically BOLD candidate gene approach caused cellular clinical Clinical course Clinical outcome clinical variability complete penetrance complex component components core gene core genes coronavirus coronavirus disease Coronavirus disease 2019 Course COVID COVID Human Genetic Effort COVID-19 COVID-19 patient COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen deficiencies deficiency defined Deleterious dendritic cell dendritic cells determine Diseases double-stranded RNA eight enrichment epidemiological studies Exome fibroblast fibroblasts Genes genes encoding genetic defect genetic defects genetics Genome genomics study had milder phenotype healthy individuals highest Hospitalized Human human fibroblasts with mutations Hypothesis identify IFN IFN response IFN-α2 IFNAR1 IFNAR1 deficiency IFNAR2 IFNs IKBKG immune system Immunity immunological in healthy individuals in some in vitro Inborn error Inborn errors incomplete penetrance individual induction pathway Infection infection with SARS-CoV-2 Infectious diseases Influenza influenza pneumonia Influenza virus inheritance interferon interferon regulatory factor interferon regulatory factor 7 interferons interferons (IFNs) involved IRF3 IRF7 IRF9 lack life-threatening likelihood loci LOF loss-of-function male mechanism Medical conditions minor minor allele frequency molecular molecule molecules monogenic inborn error monogenic inborn errors mutated Mutation NEMO NEMO/IKBKG Neutralizing nonsynonymous variant other variants outcome pathogen pathogen-induced inflammation pathway Patient patients Perspective plasmacytoid dendritic cells pLOF Pneumonia predicted Prevent produced rare variant Rare variants Regulation respiratory reveal risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro Science selected sequenced severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia severe disease Severe infection silent infection Stat1 STAT2 subject susceptible TBK1 tested Therapeutic benefit this system TICAM1 TICAM1/TRIF tissue TLR3 Toll-like receptor Toll-like receptor 3 TRAF3 TRIF Type type I Type I IFN type I IFNs type I interferon UNC93B1 underlie variant variants Viral Viral illness viral illnesses
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

생명을 위협하는 COVID-19 환자에서 I형 IFN에 대한 자가항체

Research Article

Published on 2020-10-232022-08-13
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Affect affected age antiviral immunity Asymptomatic auto-Ab auto-Abs autoantibodies autoantibody autoantibody system Autoimmune Autoimmunity B cell Beck binding can not candidate gene approach cause causes Clinical course clinical phenotype clinical phenotypes clinical variability collected complex component components Concentration conditions coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen death determine disease Diseases downstream enrichment enrolment epidemiological excess explain Genes genetics genomics study had milder phenotype healthy control healthy individual healthy individuals highest Human Hypothesis identify IFN IFN response IFN-stimulated genes IFN-α IFN-α/β IFN-α2 IFN-β IFN-γ IFNAR IFNs IgG IL-17A IL-6 immune system Immunity Immunoglobulin Immunoglobulin G immunological impair impairing in healthy individuals in vitro Inborn errors increase in individual infected with SARS-CoV-2 Infection Infectious diseases interferon interferon regulatory factor interferon-γ interferons interferons (IFNs) interleukin interleukin-6 intrinsic involved IRF ISGs lack life-threatening life-threatening coronavirus disease likelihood male mechanism men mild SARS-CoV-2 infection morbidity morbidity and mortality mucocutaneous candidiasis Mutation mycobacterial disease neutralize Neutralizing outcomes pandemic pathogen pathogen-induced inflammation pathway Patient patients patients hospitalized Perspective phosphorylated Plasmapheresis Pneumonia Prevent pSTAT receptor receptors Regulation respiratory rising risk risk factor SARS-CoV-2 SARS-COV-2 infection Science searched serum IFN-α level severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia shown silent infection staphylococcal susceptible tested the patient this system TLR Toll-like receptor Transcription Treatment trials type 1 interferon type 1 interferons type I Type I IFN type I IFNs underlie undetectable Vaccine Viral viral infections viral respiratory diseases while women
[DOI] 10.1126/science.abd4585 PMC 바로가기 [Article Type] Research Article