Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins—An Important Strategy for Developing Novel Therapeutics for the COVID-19 PandemicMolecular Biosciences Published on 2021-01-252022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] cascade caused Cell competing coronavirus Coronavirus infection COVID-19 cytokine death defined Developing Diseases drug effective Endothelial cell expressed heparan sulfate heparin high mortality IL-6 Immune cell Infection Infectious disease Inflammation inflammatory reaction Interaction interactions Invasion involved mechanism modulation novel Protein public health recruitment required SARS-CoV-2 SARS-COV-2 infection Spread Strategy subsequent sulfate therapeutic Therapeutics TNF-α Treatment Vaccines viral entry Viral protein [DOI] 10.3389/fmolb.2020.628551 PMC 바로가기 [Article Type] Molecular Biosciences
The different manifestations of COVID-19 in adults and children: a cohort study in an intensive care unit성인과 어린이의 다양한 COVID-19 발현: 중환자실 코호트 연구Research Article Published on 2021-01-202022-09-10 Journal: BMC Infectious Diseases [Category] 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults analysed ARDS Biomarker Biomarkers bloodstream C-reactive protein cause Characteristics children Clinical features clinical manifestations cohort study coronavirus COVID-19 COVID-19 disease described different clinical manifestations greater health system health systems heparin infected with SARS-CoV-2 Infection Inflammatory intensive care IQR manifestation mechanical ventilation median median age mid-regional pro-adrenomedullin MIS-C Mortality Multisystem inflammatory syndrome N-terminal N-terminal pro-B-type natriuretic peptide obesity one patient outcomes pathology Patient PEEP peptide Population pro-B-type natriuretic peptide procalcitonin prospective observational cohort Pulmonary thromboembolism required respiratory respiratory distress Respiratory distress syndrome Respiratory Support Result SARS-CoV-2 Sedation severe acute respiratory distress syndrome severe acute respiratory syndrome Coronavirus severe ARDS severe COVID-19 disease statistically significant Support susceptible patients syndrome the disease Thromboembolism treated virus was recorded [DOI] 10.1186/s12879-021-05786-5 PMC 바로가기 [Article Type] Research Article
Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia중증 코로나19 폐렴의 경우 폐혈전색전증을 동반한 심부정맥 혈전증Case Reports Published on 2021-01-152022-09-11 Journal: BMJ case reports [Category] 진단, 치료제, [키워드] Affect Anticoagulants Chest Chest CT chest pain Chest radiograph COVID-19 CTPA D-dimer Deep vein Deep vein thrombosis diabete diabetes diagnosed Doppler dry cough DVT elevated emergency department examination Fever Ground-glass opacities ground-glass opacity heparin lethal lobes lower lobes oxygen oxygen saturation popliteal popliteal veins positive Pulmonary thromboembolism radiological examination Radiological examinations radiology radiology (diagnostics) raised reduced respiratory Respiratory system Severe COVID-19 pneumonia Shortness of breath swelling Tachycardia tachypnoea temperature tested Thromboembolism thrombosis treated Venous Thromboembolism zone [DOI] 10.1136/bcr-2020-240932 PMC 바로가기 [Article Type] Case Reports
Proposal of the Definition for COVID-19-Associated CoagulopathyReview Published on 2021-01-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation adaptive caused clinical feature Coagulation Coagulopathy complement Complication COVID-19 COVID-19 patient Definition Disseminated intravascular coagulation Endothelial cell endotheliopathy event feature heparin Immunity include knowledge Laboratory large vessel lung mechanism Microvascular damage other organs pathological finding phenotype resulting similarity subject thrombotic thrombus formation up-regulated [DOI] 10.3390/jcm10020191 PMC 바로가기 [Article Type] Review
Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical ReviewReview Published on 2021-01-032022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation acute distress respiratory syndrome acute respiratory distress addition ARDS bleeding cause clinical evidence clinical manifestation clinical presentation clinician Coagulation coagulation cascade coagulation disorder coagulation factor coagulation tests Coagulopathy coronavirus disease COVID-19 COVID-19 patients Critically ill patient Disseminated intravascular coagulation endothelial endotoxin hemorrhagic event heparin Ill impairment incidence infiltration Inflammatory inhibitors Laboratory Laboratory test marker mechanism microthrombi Necrosis pathophysiology pathway Platelet platelet activation Platelets Protein protein S quantification question Regulatory reported respiratory responsible review risk supportive care syndrome thromboembolic Thromboembolic events thrombosis tissue variety [DOI] 10.3390/jcm10010140 PMC 바로가기 [Article Type] Review
Understanding the andromeda strain – The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness안드로메다 균주 이해 - SARS-CoV2 중병에서 사이토카인 방출, 응고병증 및 안티트롬빈 III의 역할Review Published on 2021-01-012022-09-11 Journal: Blood reviews [Category] SARS, 바이오마커, [키워드] Antithrombin antithrombin III autopsy analysis benefit China circulating Coagulation Coagulopathy coronavirus COVID-19 COVID-19 infections Critical Critical illness cytokine release Europe globe hematology heparin Heparin resistance mediator Microthrombosis Mortality Multiple observational studies observational study organizations pandemic Part pathology pathophysiology Patient performed physician potential therapeutic target Prognostic marker Prophylactic prothrombotic reduction reductions reported SARS-CoV SARS-CoV critical illness SARS-CoV2 severe COVID-19 infections Society temper thrombosis thrombotic thrombotic complication Thrombotic complications understanding [DOI] 10.1016/j.blre.2020.100731 PMC 바로가기 [Article Type] Review
Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 InfectionCOVID-19 감염에서 헤파린 및 관련 GAG 항혈전제의 역할에 대한 근거Review Published on 2021-01-012022-09-12 Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 진단, [키워드] complex interplay complications COVID-19 danaparoid sodium disease GAG-antithrombotics heparin immune system management pathophysiology rationale reveal role SARS-CoV-2 SARS-CoV-2 pandemic sulodexide. Treatment [DOI] 10.1177/1076029620977702 PMC 바로가기 [Article Type] Review
Prophylactic or therapeutic doses of heparins for COVID-19 infection? A retrospective studyArticle Published on 2021-01-012023-07-11 Journal: Aging Clinical and Experimental Research [Category] SARS, [키워드] COVID-19 heparin Mortality [DOI] 10.1007/s40520-020-01750-6 PMC 바로가기
From dermatological conditions to COVID-19: Reasoning for anticoagulation, suppression of inflammation, and hyperbaric oxygen therapy피부질환부터 코로나19까지: 항응고, 염증억제, 고압산소 요법의 이유Review Published on 2021-01-012022-09-12 Journal: Dermatologic therapy [Category] SARS, 진단, [키워드] anticoagulation clinical settings Coagulation complex condition COVID-19 critically ill patients death endothelial damage generate heparin Hyperbaric oxygenation Inflammation Inflammatory Inflammatory response livedoid Lung injury macrophage activation Oxygen therapy Reasoning severe COVID-19 systemic inflammatory response thrombosis translational Vasculopathy [DOI] 10.1111/dth.14565 PMC 바로가기 [Article Type] Review
Utility of d-dimer for diagnosis of deep vein thrombosis in coronavirus disease-19 infection코로나바이러스 질병-19 감염에서 심부정맥 혈전증 진단을 위한 d-dimer의 유용성Article Published on 2021-01-012022-09-11 Journal: Journal of vascular surgery. Venous and lymphatic [Category] 바이오마커, [키워드] 95% confidence interval age Analysis anticoagulation both groups Chain Reaction Cohort consecutive patient consecutive patients coronavirus coronavirus disease Coronavirus disease-19 COVID-19 criteria Cutoff D-dimer D-dimer levels Deep vein Deep vein thrombosis defined determine diabetes Diagnosis dimer DVT elevated Ethnicity Factor group groups Hemodialysis heparin in both group Infection interquartile range less median multivariable analyses multivariable analysis Negative predictive value no difference no differences Odds ratio Patient patients with COVID-19 polymerase chain polymerase chain reaction predict Predictive Predictive value Prophylactic prophylactic anticoagulation Prophylaxis selected sensitivity Sex specificity statistically significant thrombosis two groups venous was determined well Wells DVT criteria. with COVID-19 [DOI] 10.1016/j.jvsv.2020.07.009 PMC 바로가기 [Article Type] Article