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[키워드] ACE2 ACE2-RBD binding addition Affinity maturation antibodies antibody attachment bind binding affinity Characteristics competitive binding conserved Crystallographic studies Crystallographic study displaying distal domain Effect effective effective strategy epitope epitope distal Epitopes fusing fusion strategy generate high-affinity synthetic nanobody host cells host receptor hotspot identify immunological IMPROVE in vitro increase infect Infection interface kDa library screening llama-derived single-chain nanobodies nanobodies nanobody nanomolar affinity neutralization activity Neutralizing Neutralizing activity Neutralizing antibodies offer potency probe Protein provide pseudovirus RBD RBD binding RBD-targeting nanobodies RBD-targeting nanobody RBM RBM-antibodies RBM-binders Receptor-binding domain receptor-binding motif recognize recognizing Research S RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus simple simplicity single-chain antibody speed spike Spike protein spike receptor-binding domain SR31 structure-based design sybody target the receptor-binding domain the SARS-CoV-2 therapeutic tool protein toolkit two modestly neutralizing sybodies
[DOI] 10.1371/journal.ppat.1009328 PMC 바로가기 [Article Type] Research Article