Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA projectArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 95% confidence interval 95%CI age analyzed anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody Clinical characteristics Cohort contrary COVID COVID – 19 COVID-19 vaccination determinant distribution dose European Gender Germany HCW HCWs Health care worker Health Care Workers (HCW) healthcare worker Heterologous IgG immune immune response Infection International Italy log log-transformed normalized offer predicted random-effects meta-analyses ranged Regression model risk Romania serological response serology Sex Slovakia Sociodemographic spike Standard deviation time vaccination Vaccine vaccine dose vaccine doses [DOI] 10.3389/fimmu.2022.986085 PMC 바로가기
Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concernArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] addition AstraZeneca Beta booster booster dose CD4 CD4+ CD8+ central memory ChAdOx1 Concentration COVID-19 COVID-19 vaccine Delta evaluated follicular highest homologous IFN-gamma IgG IgG antibody IgG isotype IL-17 Immune escape immunogenic immunogenicity induce memory mice mice immunization neutralizing antibody Neutralizing antibody titer new SARS-CoV-2 performed Population populations Protein S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants significantly higher spike trimer spike trimeric protein T cells tested trimeric Trimeric spike protein Vaccine vaccine candidate Vaccines variant variants viral variant virus viruses VoC Wuhan [DOI] 10.3389/fimmu.2022.1020159 PMC 바로가기
Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysisArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome addition Antibody Response Antigen BAL Bronchoalveolar lavage clearance coronavirus coronavirus disease COVID-19 cross-sectional analysis domain fatal COVID-19 function IgA IgG IL-1β immune complex Infection Inflammatory Inflammatory cytokine lung mucosal mucosal immunity neutralization Neutralizing activity Neutralizing titer nucleocapsid protein outcome Patient persistent Protective RBD RBD variants reduced replicate SARS-CoV-2 SARS-CoV-2-specific antibody severe COVID-19 patients Severe infection Survivors tested viral clearance virus virus elimination with COVID-19 Wuhan [DOI] 10.3389/fimmu.2022.842468 PMC 바로가기
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Persistent Antibody Responses Up to 18 Months After Mild Severe Acute Respiratory Syndrome Coronavirus 2 InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Antibody Response Antibody titer B.1.1.529 B.1.1.7 B.1.167.2 binding activity circulating variant coronavirus coronavirus 2 coronavirus disease COVID-19 cytopathic delta variant domain ELISA enzyme-linked immunosorbent assays humoral IgA IgG IgG antibody IgM immune Immunity Immunoglobulin Infection Live virus median Mild Month Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer P.1 Patient persistent Protein RBD RBD protein respiratory response SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 variant serological response serum antibody serum sample variant virus was reduced were measured wild-type wild-type SARS-CoV-2 Wuhan-1 [DOI] 10.1093/infdis/jiac099 PMC 바로가기
Hygienic behaviors during the COVID-19 pandemic may decrease immunoglobulin G levels: Implications for Kawasaki diseaseArticle Published on 2022-09-282022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] accelerated Adults Affect all age group all age groups children control subject coronavirus disease COVID COVID-19 COVID-19 outbreak COVID-19 pandemic Decline declined decrease examined explain Health hygiene Hypothesis IgE IgG IgG level Immunoglobulin immunological parameter individual Infection Kawasaki disease Neonate nonspecific pandemic Patient predict quantified recorded significantly lower steadily decreased [DOI] 10.1371/journal.pone.0275295 PMC 바로가기
Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profileArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women [DOI] 10.3389/fimmu.2022.999136 PMC 바로가기
Rational Design and Development of SARS-CoV-2 Serological Diagnostics by Immunoprecipitation-Targeted ProteomicsArticle Published on 2022-09-272022-11-15 Journal: Analytical Chemistry [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] anti-RBD anti-SARS-CoV-2 antibody approach Combination convalescent convalescent plasma COVID-19 cross-reactivity current Cutoff detect development diagnostic Diseases domain elevated facilitate highest human immunoglobulin IgA IgA2 IGD IgE IgG IgG1 IgG2 IgG3 IgG4 IgM immune response immunoassay Immunoglobulin include isotype lack limit of detection limitation offer plasma Protein proteomic proteomics quantification Saliva SARS-CoV-2 serological Serological assay serological test serum significantly Simultaneous Standardization suggested [DOI] 10.1021/acs.analchem.2c01325 PMC 바로가기
Circulating multimeric immune complexes contribute to immunopathology in COVID-19Article Published on 2022-09-262022-11-15 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료제, [키워드] activating Activation Antiviral circulating comparable contribute COVID-19 COVID-19 progression Critical detrimental disease driven by dysregulated immune response Evidence extreme FcγRs humoral identify IgG IgG response immune complex immunopathology independent Intervention Ligand mitigate paradoxical Patient patients Protective reporter robust SARS-CoV-2 severe COVID-19 SLE specific IgG antibody systemic immune dysregulation systemic lupus erythematosus triggering with mild disease [DOI] 10.1038/s41467-022-32867-z PMC 바로가기
SARS-CoV-2 IgG spike protein antibody response in mRNA-1273 Moderna® vaccinated patients on maintenance immunoapheresis – a cohort studyArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] antibody Antibody Response Autoimmune disease average cohort study Control COVID-19 Effectiveness groups humoral immune response IgG IgG apheresis immune response Immunoadsorption Immunocompromised Immunoglobulin immunosuppressive drugs increased mortality independent LDL less Moderna morbidity mRNA-1273 outcome Patient patients populations Protein reduction SARS-CoV-2 IgG SARS-CoV-2 IgG spike (S) protein antibody SARS-CoV-2 pandemic secondary outcome Spike protein the median Treatment vaccination [DOI] 10.3389/fimmu.2022.969193 PMC 바로가기