IL-2 – Page 17 – Communicable Diseases Research

Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis

Research

Published on 2020-06-102022-10-29
Journal: Journal of Hematology & Oncology [Category] COVID-19, SARS,

[키워드] 95% CI 95% confidence interval age Analysis analyzed Cancer Cancer history, Independent risk factor cancer patient Cancer patients Clinical outcome Comorbidities Comorbidity Complete Complication Control coronavirus disease COVID-19 COVID-19 patient Effect Elevation epidemiological erythrocyte sedimentation rate evaluated exhibited Factors ferritin Hematological malignancy High-sensitivity C-reactive protein higher risk Hospitalized hospitalized COVID-19 hospitalized COVID-19 patients IL-2 IL-6 immune Impact independent risk factor inflammatory reaction interleukin-6 laboratory parameter Logistic regression analysis Mortality mortality rate nine Odds ratio outcomes Patient patients patients with COVID-19 procalcitonin Prognostic factor Propensity score propensity score matching Prothrombin time receptor Research Result Retrospective study risk SARS-CoV-2 Selection bias Sex significant increase significantly significantly higher solid tumor Tongji Hospital was used with COVID-19 Wuhan, China
[DOI] 10.1186/s13045-020-00907-0 PMC 바로가기 [Article Type] Research

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping

Review

Published on 2020-06-102022-10-29
Journal: Journal of Inflammation (London, England) [Category] COVID-19,

[키워드] ACE2 Activation age angiotensin-converting enzyme 2 caused condition COVID-19 COVID-19 infection COVID-19 patients COVID-19 susceptibility Cytokine storm develop diabetes disease E-cigarettes effective therapy engulfment epithelial permeability Future globe GM-CSF high affinity hypertension IFN-γ IL-2 IL-6 IL-7 immune responses Inflammation inflammatory storm IP-10 lung lung epithelium MCP-3 membrane morbidity and mortality Mortality outcome pandemic of COVID-19 pro-inflammatory Proteases provide receptor Research response S1 domain SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe disease shown smoking target the SARS-CoV-2 therapy TMPRSS2 protease TNF-α vaping viral entry
[DOI] 10.1186/s12950-020-00250-8 PMC 바로가기 [Article Type] Review

Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Special Section: SARS-CoV-2

Published on 2020-06-092022-10-30
Journal: National Science Review [Category] COVID-19,

[키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection 2019-nCoV infections blood plasma caused changes in Characteristics characterized China clinical feature combating COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine response Cytokine storm Cytokines disease severity elevated emerging disease function G-CSF healthy individuals HGF IFN-α2 IFN-γ IL-10 IL-12 IL-17 IL-1α IL-2 IL-4 IL-7 IMPROVE IP-10 Lung injury M-CSF mechanism MONITOR outbreak pathogenesis of COVID-19 Patient plasma Pneumonia Potential biomarker predict reported SARS-CoV-2 selective severity Shenzhen significantly the disease therapeutic treat Viral load Wuhan, China
[DOI] 10.1093/nsr/nwaa037 PMC 바로가기 [Article Type] Special Section: SARS-CoV-2

The inhibition of IL-2/IL-2R gives rise to CD8 + T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia

Article

Published on 2020-06-082022-10-04
Journal: Cell Death & Disease [Category] SARS, 치료기술, 치료법,

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Research Article

Published on 2020-05-312022-10-06
Journal: Emerging Microbes & Infections [Category] MERS, SARS, 진단,

[키워드] Analysis analyzed can be used control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill patient CRP cytokine Cytokine storm death Diagnosis disease deterioration disease severity enrolled group healthy volunteer higher risk IFN-γ IL-10 IL-2 IL-4 IL-6 immunoassays indicated individuals Inflammatory cytokines Interleukin 10 interleukin 6 Logistic regression analysis lung damage majority Mild moderate multiple organ dysfunction outbreak outcome Patient positively correlated Predictive predictor profile Profiling reduce Renmin Hospital Respiratory failure Result reveal SARS-CoV-2 serum serum cytokine Serum level serum sample severe disease significantly higher Spread Symptoms syndrome TNF-α Treatment while Wuhan, China
[DOI] 10.1080/22221751.2020.1770129 PMC 바로가기 [Article Type] Research Article

Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV)

Article

Published on 2020-05-062022-10-30
Journal: Journal of pharmaceutics and drug research [Category] COVID-19,

[키워드] 2019-nCoV Analysis antiviral agent antiviral drug antiviral drugs approach bat BLASTn carried China Chloroquine coding Compound concentrations coronavirus Coronavirus infection derivative docking result Docking tools drug drug combination effective Folic acid Genome genome analysis genomic glycoprotein identify IL-2 IL-6 inhibit inhibitory ligands multi new virus niacinamide novel Novel coronavirus Novel coronavirus infection pneumonia case Polymerase inhibitors Protease inhibitor protease inhibitors Proteases Protein Protein target RdRP Ritonavir SARS Coronavirus SARS-CoV-2 Screening shown SMART BLAST and WebDSV 2.0 specific treatment spike target the disease the SARS-CoV-2 throughput treat urgency WHO Wuhan
PMC 바로가기 [Article Type] Article

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

Article

Published on 2020-05-042022-10-31
Journal: Cell Discovery [Category] COVID-19,

[키워드] affected Analysis antibody B cells BCR caused CD14 CD4 CD8 Cell change classical Course COVID-19 COVID-19 patient COVID-19 patients early recovery Evidence expressed frequencies Gene Expression greater hospital discharge identification IGHV3-15 IGHV3-23 IGHV3-30 IGHV3-7 IGKV3-11 IL-18 IL-1β IL-2 IL-4 IL1β Immune cell immune signature immunology indicated Inflammatory inflammatory gene inflammatory storm isotype M-CSF Mechanisms of disease monoclonal monocyte mononuclear cell naïve B cell Patient Peripheral blood Plasma cell predicted provide reported SARS-CoV-2 Sequencing Signaling significantly single-cell Single-cell RNA sequencing specificity subset T cell target gene TNFSF13 transcriptional change Treatment Vaccine Vaccine development virus
[DOI] 10.1038/s41421-020-0168-9 PMC 바로가기 [Article Type] Article

Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice

Research Article

Published on 2020-04-152024-09-02
Journal: BMC Complementary Medicine and Therapies [Category] 대상포진,

[키워드] Anti-inflammation herpes simplex keratitis IL-2 Ixeris Sonchifolia (Bae.) Hance Total flavonoids
[DOI] 10.1186/s12906-020-02911-w PMC 바로가기 [Article Type] Research Article

Innate Activation of IFN-γ—iNOS Axis During Infection With Salmonella Represses the Ability of T Cells to Produce IL-2

감염된 살모넬라와의 상호작용 중 IFN-γ—iNOS 축의 선천적 활성화는 T 세포의 IL-2 생산 능력을 억제한다.

Original Research

Published on 2020-03-252024-07-29
Journal: Frontiers in immunology [Category] 살모넬라증,

[키워드] IFN-γ IL-2 iNOS nitric oxide Salmonella Typhimurium splenocytes T cell
[DOI] 10.3389/fimmu.2020.00514 PMC 바로가기 [Article Type] Original Research

Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis

Article

Published on 2019-07-262022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,