Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients코로나19 환자의 중증도와 관련된 면역글로불린 및 보체 소비를 유도하는 규제 완화된 세포 회로Article Published on 2021-03-012022-09-12 Journal: European Journal of Immunology [Category] SARS, 진단, [키워드] Activation Admission B cells C5a cause CD16 CD56 cellular circulating complement Complement C3 COVID-19 COVID-19 patients discharged driving follicular healthy donors helper T cell Hospitalized host immune system humoral Humoral immunity IgA IgG IgG1 IgG3 IgM immune response Immunity Immunoglobulin immunoglobulins Infection investigated isotypes lymphopenia Mild moderate NK cell NK-cell outcome Patient peptide Peripheral blood plasmablasts progression proportion protein level provide responsible SARS-CoV-2 severe patients severity severity of COVID-19 target therapeutic intervention [DOI] 10.1002/eji.202048858 PMC 바로가기 [Article Type] Article
Encephalopathy and encephalitis during acute SARS-CoV-2 infection. Spanish Society of Neurology COVID-19 Registry급성 SARS-CoV-2 감염 중 뇌병증 및 뇌염. 스페인 신경 학회 COVID-19 등록Observational Study Published on 2021-03-012022-09-11 Journal: Neurología (Barcelona, Spain) [Category] SARS, 임상, 진단, 치료기술, [키워드] acute SARS-CoV-2 infection alteration brain MRI Characteristics Coma Complication complications conducted Confusion confusional Corticosteroid Corticosteroids COVID-19 COVID-19 pandemic Encefalitis Encefalopatías Encephalitis Encephalopathy healthcare professionals Immunoglobulin immunoglobulins Infection lumbar Lumbar puncture men Mild moderate multicentre Neurological involvement Neurological symptom Neurological symptoms NEUROLOGY Patient patients patients treated performed positive PCR positive PCR result presenting progressed Registered Registro SEN registry reported retrospective SARS-CoV-2 SARS-CoV2 SEN registry. Society Spanish Symptom syndrome was performed women [DOI] 10.1016/j.nrl.2020.11.013 PMC 바로가기 [Article Type] Observational Study
Distinct antibody repertoires against endemic human coronaviruses in children and adultsResearch Article Published on 2021-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] Acidic Acute respiratory infection antibody antibody repertoire Antibody Response B cell epitopes B cell response children Cohort comprehensive analysis conserved Coronavirus infection Coronaviruses cross-reactive dominant donors endemic HCoV endemic human coronavirus Epidemic fusion peptide HCoV-HKU1 human antibody response humans IgG immunoglobulins immunology immunoprecipitation Infectious disease linear monoclonal antibody N-terminal nucleocapsid peptide polyprotein predominant Prophylactic Proteins ranged Region S2′ cleavage Sequencing Seroprevalence specificity the spike protein therapeutic Vaccine design virus [DOI] 10.1172/jci.insight.144499 PMC 바로가기 [Article Type] Research Article
Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19심각한 COVID-19 생존자의 첫 번째 물결에서 항혈청의 효과적인 바이러스 중화 활동Research Article Published on 2021-02-222022-09-10 Journal: JCI Insight [Category] MERS, 진단, 치료법, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Antibody Response Antibody responses Antisera caused collected convalescent phase coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 cases declined First wave Health crisis humoral immune response identify IgG IgG level IgG levels immunoglobulins knowledge Longevity magnitude Neutralizing antibodies neutralizing antibody nucleocapsid protein pandemic Patient patients with COVID-19 performed public health crisis RBD Receptor binding domain respiratory SARS-CoV-2 serological serum severe acute respiratory syndrome Coronavirus severe COVID-19 specimen survivor Vaccines virus-neutralizing Wuhan Wuhan, China [DOI] 10.1172/jci.insight.146267 PMC 바로가기 [Article Type] Research Article
The Antiviral Properties of Human Milk: A Multitude of Defence Tools from Mother Nature모유의 항바이러스 특성: 대자연의 다양한 방어 도구Review Published on 2021-02-222022-09-10 Journal: Nutrients [Category] MERS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antiviral activity Antiviral compound Antiviral compounds assist breast milk Compound described docosahexaenoic acid (DHA) expand Future Human human milk human milk oligosaccharides (HMO) immunoglobulins Interaction knowledge lactoferrin long-chain polyunsaturated fatty acids (LCPUFA) mucins multitude Nature non-specific pandemic Pathogens property Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 synergistic tenascin-C therapy these compound these compounds variety viruses [DOI] 10.3390/nu13020694 PMC 바로가기 [Article Type] Review
Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC뉴욕 브롱크스에서 회복기 혈장으로 중증 COVID-19 치료Comparative Study Published on 2021-02-222022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acute respiratory disease Admission adverse effect age aging analyses antibody anticoagulation body mass body mass index CCP Clinical outcome Comorbidities Control Controlled trial controlled trials controls convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 criteria D-dimer Deterioration Efficacy Ethnicity hospitalized patient hospitalized patients IgA titer IgA titers IgG IgM immunoglobulins Infectious disease less lower risk lymphocyte lymphocyte counts matching median Mortality no difference oxygen Oxygen requirement Oxygenation patients with COVID-19 plasma promise Propensity score recipient recipients SARS-CoV-2 severe COVID-19 Sex Spike protein stratified Treatment [DOI] 10.1172/jci.insight.142270 PMC 바로가기 [Article Type] Comparative Study
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein천연 SARS-CoV-2 스파이크 단백질에 대한 중화 인간 항체 검출을 위한 유동 세포 계측법 다중화 방법Article Published on 2021-02-172022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody blood donor Blood donors classification coding sequence COVID‐19 cytometer Cytometry detect EGFR example expresse expressed Flow flow cytometry fluorescence intensities fluorescence intensity human population immune Immunoglobulin immunoglobulins immunology individual Infection method Methods & Resources Microbiology, Virology & Host Pathogen Interaction Neutralizing Neutralizing activity outbreak pandemic PCR Protective Protein Quantitative repeated respiratory S protein SARS‐CoV‐2 SARS‐CoV‐2 separated sequence sera serological test Serological tests seropositive individual seropositive individuals Seropositivity severe acute respiratory syndrome Coronavirus Spike protein T cell T‐cell [DOI] 10.15252/emmm.202013549 PMC 바로가기 [Article Type] Article
The Rheumatology Drugs for COVID-19 Management: Which and When?Review Published on 2021-02-162022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] absence anti-IL-1 anti-IL-6 anti-IL-6 drugs anti-TNF antiviral therapy approach approved Baricitinib characterized Clinical management Clinical outcome Cochrane Library Colchicine Complication concerning Corticosteroids COVID-19 database drug hallmark HCQ heterogeneity hyperinflammatory status IL-2 IL-6 IL-7 IL-8 immunoglobulins immunomodulatory drug intravenous Necrosis neutralize patients patients with COVID-19 Pneumonia Result rheumatic disease SARS-CoV2 searched severe COVID-19 patients therapeutic strategy Treatment Vaccine while [DOI] 10.3390/jcm10040783 PMC 바로가기 [Article Type] Review
Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study여성들이 다양한 지리적 지역에서 생산한 우유의 IgA 및 IgG 항원 특이성에 대한 다중 병원체 분석: INSPIRE 연구Original Research Published on 2021-02-112024-07-30 Journal: Frontiers in immunology [Category] 세균성이질, [키워드] Breastfeeding breastmilk human milk IgA IgG immunoglobulins pathogen Protein array [DOI] 10.3389/fimmu.2020.614372 PMC 바로가기 [Article Type] Original Research
Production of hyperimmune anti-SARS-CoV-2 intravenous immunoglobulin from pooled COVID-19 convalescent plasma풀링된 COVID-19 회복기 혈장에서 과면역 항-SARS-CoV-2 정맥 면역글로불린 생산Research Article Published on 2021-02-092022-09-12 Journal: Immunotherapy [Category] MERS, SARS, 진단, [키워드] anti-COVID-19 IVIG anti-SARS-CoV-2 caprylic acid clinical trial convalescent plasma COVID-19 cut-off diafiltration effective Efficacy evaluated feasibility feasible hyperimmune immunization Immunoglobulin immunoglobulins Immunotherapy Intravenous immunoglobulin Intravenous immunoglobulins intravenously material passive immunization pooled plasma producing Production protein concentration Safe SARS-CoV-2 SARS-CoV-2 antibody Treatment Ultrafiltration [DOI] 10.2217/imt-2020-0263 PMC 바로가기 [Article Type] Research Article