Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A ProteaseArticle Published on 2018-12-052023-08-29 Journal: Viruses [Category] E형 간염, [키워드] Enterovirus 71 EV-A71 protease 2A innate immune system Toll-like receptor 3 Type I IFN [DOI] 10.3390/v10120689 PMC 바로가기 [Article Type] Article
Transcriptomic Characterization of a Chicken Embryo Model Infected With Duck Hepatitis A Virus Type 1Original Research Published on 2018-08-242023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] SOCS chicken embryo models duck hepatitis A virus type 1 innate immune system transcriptomic analysis [DOI] 10.3389/fimmu.2018.01845 PMC 바로가기 [Article Type] Original Research
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon ResponsesResearch Article Published on 2018-05-012022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] absence antibodies Betacoronavirus caused cellular coronavirus CoV CoVs cultured cells Effect genomic genomic RNA gRNA IFN IFNAR in viral in vitro in vivo increases in Infection innate immune innate immune response innate immune system interferon interferon response interferon signaling locus marrow-derived macrophage MAVS mechanism MHV mice murine hepatitis virus mutant mutant virus Mutation not affect Nsp15 ORF1b packaged packaging signal Pathogenesis pathogenicity positive positive-sense promote receptor reduced remained replicated Replication required response restored RNA RNA molecule RNA packaging RNAs selective selective packaging significantly strain subgenomic RNAs These data TLR7 treated Type virion virions virulence virus virus replication viruses weight loss [DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathwayResearch Published on 2015-08-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation adapter African green monkey antiviral immune response blockade blocked cell line damaged demonstrated digestive disorders epidemic diarrhea epithelial cell expression Host identify IFN IFN-β immune cell population immune function in vitro in vivo induce Infection inhibit inhibited inhibitor of κB innate immune system Interaction interferon Intervention intestinal epithelia intestinal epithelial cell intestinal epithelial cells investigated kidney kinase-ε lack Limited mechanism molecular mechanism NF-κB nuclear offered Pathogenesis pathway PEDV promoter Regulatory Result RIG-I signaling pathway target cell transcription factors Type type I interferon upstream Vero Cell virus were used [DOI] 10.1186/s12985-015-0345-x PMC 바로가기 [Article Type] Research
Comparative Biology of the Pentraxin Protein Family: Evolutionarily Conserved Component of Innate Immune System펜트락신 단백질 가족의 비교 생물학: 선천 면역 시스템의 진화적으로 보존된 구성 요소book-chapter Published on 2015-01-012024-08-04 Journal: International Review of Cell and Molecular Biology [Category] 폐렴구균 감염증, [키워드] C-reactive protein complement system CRP receptor Extracellular matrix innate immune system lipopolysaccharide opsonization Pentraxin. [DOI] 10.1016/bs.ircmb.2015.01.002 [Article Type] book-chapter
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Strategies to increase the activity of microglia as efficient protectors of the brain against infectionsarticle Published on 2014-05-222024-09-02 Journal: Frontiers in Cellular Neuroscience [Category] 대상포진, [키워드] Bacteria blood–brain barrier blood–CSF barrier innate immune system microglia palmitoylethanolamide phagocytosis [DOI] 10.3389/fncel.2014.00138 PMC 바로가기 [Article Type] article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene [DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article