intranasal – Page 17 – Communicable Diseases Research

Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

IgM의 비강 전달은 SARS-CoV-2 변종으로부터 광범위한 보호를 제공합니다.

Article

Published on 2021-07-012022-09-11
Journal: Nature [Category] MERS, SARS, 변종, 진단, 치료제,

HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis

만성 B형 간염에 대한 치료 백신인 HeberNasvac은 선천 면역의 국소 및 전신 표지자를 자극합니다: SARS-CoV-2 노출 후 예방에 잠재적 사용

Article

Published on 2021-07-012022-09-11
Journal: Euroasian J Hepatogastroenterol [Category] 비임상,

[키워드] Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral properties antiviral property both sexes breath CHB chronic chronic hepatitis Chronic Hepatitis B clinical trial Cohort coronavirus coronavirus disease COVID-19 Dengue died Disease progression dose enrolled evidenced expression functional Hepatocellular carcinoma immune cells Immunity immunomodulating immunomodulatory immunomodulatory effect impairment increased expression Innate innate immune cell Innate immune cells Innate immunity intranasal lethal infection Local Lymphocytes malignancies malignancy marker material mice monocyte Monocytes mononuclear cell nasopharyngeal Older Open-label pandemic Patient patients PBMC Peripheral blood periphery Postexposure Postexposure Prophylaxis Potential presenting prophylactic therapy Prophylaxis randomized clinical trial reduction in respiratory infections Result Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown subjects surrogate markers Symptom symptoms of COVID-19 systemic the patient therapeutic therapy Toll-like receptor Toll-like receptors tonsils Treatment Vaccine
[DOI] 10.5005/jp-journals-10018-1344 PMC 바로가기 [Article Type] Article

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant

혈통 A SARS-CoV-2 변이체를 사용한 이전 에어로졸 감염은 햄스터를 질병으로부터 보호하지만 B.1.351 SARS-CoV-2 변이체에 의한 재감염은 보호하지 않습니다.

Research Article

Published on 2021-06-262022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단,

[키워드] aerosol aerosol exposure anamnestic response B.1.351 caused circulation Contact direct contact disease exposure to fomite hamster hamsters HCoV HCoV-19 Heterologous humoral induce Infection Infection route infection with SARS-CoV-2 Infectious virus initial intranasal Lineage lose weight low dose Lungs majority mild infection naïve neutralization neutralize Neutralizing onward transmission pathology Prevent PROTECT protective immunity provide Pulmonary pathology Reinfection remained Replication SARS-CoV-2 SARS-CoV-2 variant seroconverted Syrian hamster These data titre titres Transmission triggered variants variants of concern virus VoC VOCs WA1 weight weight loss
[DOI] 10.1080/22221751.2021.1943539 PMC 바로가기 [Article Type] Research Article

Intranasal Vaccination Strategy to Control the COVID-19 Pandemic from a Veterinary Medicine Perspective

Perspective

Published on 2021-06-242022-10-28
Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19,

Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19

경증 COVID-19의 상부 호흡기 증상을 감소시키는 Ivermectin Mucoadhesive Nanosuspension Nasal Spray의 임상, 생화학적 및 분자 평가

Randomized Controlled Trial

Published on 2021-06-152022-09-11
Journal: International journal of nanomedicine [Category] 임상, 치료제,

[키워드] age Anosmia anti-parasitic assessment assessments biochemical biochemical and molecular biochemical parameter Biochemical parameters Blood C-reactive protein clinical clinical trial Complete complete blood counts cough COVID-19 D-dimer diagnosed dimer Duration Dyspnea effective female Fever gastrointestinal symptoms hematological in vitro inhibit SARS-CoV-2 intranasal Ivermectin ivermectin nanosuspension male Manifestations Mild nasal Nasal spray nasal spray. Nasopharyngeal swab nasopharyngeal swabs Negative PCR negativity nucleic acid Patient performed Pharyngeal swab presenting protocol Randomly Replication respiratory rRT-PCR Safe SARS-CoV-2 replication Serum ferritin shown significant difference significantly shorter spray the patient therapeutic efficacy Treatment upper viral clearance was performed
[DOI] 10.2147/IJN.S313093 PMC 바로가기 [Article Type] Randomized Controlled Trial

SARS-CoV-2 infection and transmission in the North American deer mouse

북미 사슴 쥐의 SARS-CoV-2 감염 및 전파

Article

Published on 2021-06-142022-09-10
Journal: Nature Communications [Category] Fulltext, MERS, SARS, 조류인플루엔자, 진단, 치료기술,

Pathophysiology and possible treatments for olfactory-gustatory disorders in patients affected by COVID-19

Review article

Published on 2021-06-052022-10-05
Journal: Current Research in Pharmacology and Drug Discovery [Category] 치료법,

[키워드] ACE2 ACE2 receptor addition affected Ageusia alveolar epithelial cell alveolar epithelial cells Anosmia approach Bronchial epithelium cause changes in Clinical management co-expression COVID-19 decrease described disorder disorders effective therapy Evidence expressed gastrointestinal tract host cell implication include infect influence Interaction intranasal involved knowledge Loss of Smell mechanism nasal olfactory olfactory disorder olfactory dysfunction omega-3 pathophysiology Patient patients with COVID-19 pharmacological Protein receptor SARS-CoV-2 sensitivity sensory neuron shown sialic acid Smell sodium specific treatment spike Taste Therapeutics therapy TMPRSS2 transmembrane serine protease treat Treatment virus vitamin A
[DOI] 10.1016/j.crphar.2021.100035 [Article Type] Review article

Asystole During Nasopharyngeal Swab: Is COVID-19 to Blame?

Cardiology

Published on 2021-06-042022-10-31
Journal: Cureus [Category] COVID-19,

Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication

Research Article

Published on 2021-05-282022-10-28
Journal: PLoS ONE [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome Angiotensin converting enzyme-2 animal model antibody applied binding binding interactions binding site carried caused Concentration coronavirus COVID-19 Critical Culture effective evaluated feasibility feasible global pandemic glycoprotein human Ace2 protein immunized Immunoglobulin in vitro Infection Infectious disease inhibit inhibited inhibiting initial intranasal intranasally mitigate mucosal pandemic peak concentration peaking produced Prophylaxis PROTECT Protective Protein raised receptor Receptor binding reducing replication of SARS-CoV-2 respiratory pathogen Result resulting SARS-CoV-2 shown significantly specificity spike glycoprotein spread of COVID-19 the SARS-CoV-2 virus titer Vaccine Vero Cell viral replication viral spike virulence virus
[DOI] 10.1371/journal.pone.0252399 PMC 바로가기 [Article Type] Research Article

Delivery Routes for COVID-19 Vaccines

Review

Published on 2021-05-192022-10-28
Journal: Vaccines [Category] COVID-19,