isolates – Page 17 – Communicable Diseases Research

Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

재결합 병원체에서 개체군 역학 및 선택을 측정하기 위한 혈통별 식별 분석

Research Article

Published on 2018-05-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

Genome wide comparison of Ethiopian Leishmania donovani strains reveals differences potentially related to parasite survival

에티오피아 Leishmania donovani 균주의 게놈 전체 비교는 기생충 생존과 잠재적으로 관련된 차이점을 보여줍니다

Research Article

Published on 2018-01-092022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Analysis Author biological processe carried caused Chain Reaction chromosome chromosome 10 clone clones CNV Concentration copy number correlated correlation deaths described difference drug drug resistance drug treatment drugs East Ecology Ethiopian examined example exhibiting foci folate genetic difference genetic differences genomic sequencing Genotype Good group groups HIV homolog Indian subcontinent involved isolate isolates karyotype Leishmania Leishmania donovani Leishmaniasis methotrexate molecular functions MTX not correlated nucleotide occur parasite parasites Patient phenotype polymerase chain polymerase chain reaction polymorphism Quantitative quantitative polymerase chain reaction Region regions reported resulting reveal sensitivity single copy single nucleotide Single nucleotide polymorphism SNP strain survival Treatment unique Variation vectors viability visceral leishmaniasis WGS whole genome whole genome sequence
[DOI] 10.1371/journal.pgen.1007133 PMC 바로가기 [Article Type] Research Article

A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombination

Research

Published on 2017-06-122022-10-28
Journal: Virology Journal [Category] Coronavirus,

[키워드] Accessory genes avian coronavirus cause Cell cell lines cells Characteristics chicken chimeric co-transfected coding Complete coronavirus ectodomain Embryonated eggs generate genetics Genome genomic growth IBV in vivo infect Infectious Bronchitis Virus isolates Major marker MHV Modification Molecular biology mouse hepatitis virus murine mutations parental poultry recombinant Recombination replaced respiratory pathogen Result Reverse genetics system RNA RNA recombination specific mutation spike gene spike glycoprotein strain Strains supplementary material synonymous Targeted RNA recombination Vaccine Vaccine development virulent virus was performed was used wild-type
[DOI] 10.1186/s12985-017-0775-8 PMC 바로가기 [Article Type] Research

Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultry

Research Article

Published on 2017-05-042022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci

포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거

Research Article

Published on 2017-04-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed
[DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article

A genetic switch controls the production of flagella and toxins in Clostridium difficile

유전자 스위치는 Clostridium difficile의 편모 및 독소 생성을 제어합니다

Research Article

Published on 2017-03-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate addition antibiotic Bacteria Bacterial Bacterial infection bacterial pathogen cause characterization Clostridium difficile colonization Control Coordinate Course degrade described determinant determine detrimental effect diarrheal diarrheal disease disease early stage Effect engage enzyme epithelial cells Evidence expressed expression Factor flagella flagellar flagellar gene flagellum Gene Expression Gene regulation Genes Genetic growth Host host tissue Impact in vitro inactivation independent independent of Infection intestinal intestinal epithelial cells intestine inversion isolates mechanism motility mRNA Mutagenesis occur Orientation pathogen phase produced promote regulate Regulation regulator Regulatory responsible secrete secreted secretion sequence severity SigD Structure toxin toxins tyrosine upstream virulence virulence factors
[DOI] 10.1371/journal.pgen.1006701 PMC 바로가기 [Article Type] Research Article

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides

비정규 RNA 분해 경로는 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이를 억제합니다

Research Article

Published on 2017-03-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate Activation animal hosts Antifungal treatment Community component Compound conditions Degradation described determined by Dicer drug target drug-resistant effective Efficacy emerging disease ENhance environmental condition environmental conditions expression FK506 fungal Fungal infection fungal pathogen fungal pathogens fungi generate genetic analysis growth Helicase Host host-pathogen interaction host-pathogen interactions Human include inhibitory inhibitory effect involved isolate isolates lack mechanism molecular mechanism mRNA degradation Mucor Mucorale Mucorales Mucormycosis Mutation non-canonical RNA pathogen Pathogens pathway performed phenotype phenotypic plasticity prevented previous study Prognosis Protein provided RdRP recent Regulation represse Research RNAi RNAi pathway strain Strains stress conditions suppresse Target genes underlie
[DOI] 10.1371/journal.pgen.1006686 PMC 바로가기 [Article Type] Research Article

Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence

Research Article

Published on 2017-03-162022-10-28
Journal: PLoS ONE [Category] Coronavirus,

Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome

Article

Published on 2017-03-092022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

아메리카 대륙에서 뚜렷한 헬리코박터 파일로리 하위 집단의 급속한 진화

Research Article

Published on 2017-02-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adaptation admixture Affect African allele alleles America Americas Asian association Atypical Bacteria Bacterial best bottleneck bottlenecks Cancer CENTRAL colonization colonize discrepancy dispersal Diversity ethnic group Ethnic groups European Evidence Evolution example fixed gene pools Genetic Genome genome sequence H . pylori Helicobacter pylori Host hosts Human human migrations humans immune system Interaction investigated involved isolate isolates Latin America melting pot Migration National North North America organism outer membrane pathogenic Population populations Prevalence prevalent Protein public health Rapid remained South South America Spread stomach strain Strains subpopulation Transmission
[DOI] 10.1371/journal.pgen.1006546 PMC 바로가기 [Article Type] Research Article