Global Spread of Coronavirus Disease 2019 and Malaria: An Epidemiological Paradox in the Early Stage of A PandemicEditorial Published on 2020-04-162022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE-2 receptor ACE2 adverse effect Analysis analyzed Antimalarial drugs Antimalarials Antiviral coronavirus disease coronavirus epidemics Coronavirus infection COVID-19 COVID-19 outbreak distribution Endemic epidemiological epidemiological paradox Genetic variation initial malaria mechanism mechanism of action medications molecular pandemic paradox Population PROTECT protective role Research retinal toxicity Stage These data [DOI] 10.3390/jcm9041138 PMC 바로가기 [Article Type] Editorial
A potential protective role of losartan against coronavirus-induced lung damageLetter to the Editor Published on 2020-03-172022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, SARS, [키워드] losartan lung damage protective role [DOI] 10.1017/ice.2020.80 PMC 바로가기 [Article Type] Letter to the Editor
Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus InfectionsReview Published on 2019-10-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition alphavirus caused Clinical outcome Coronaviruses evade Genetic Host human pathogen immune evasion immune response immunopathology implicated Infection inflammatory disease Innate innate immune innate immune evasion innate immune response innate immune system interferon less molecular mechanism Pathogenesis pathology positive-sense single-stranded RNA viruses prevalent protective role public health replication capacity Research RNA single-stranded the interferon type I and III interferons viral disease viral infection viral pathogenesis virus viruses [DOI] 10.3390/v11100961 PMC 바로가기 [Article Type] Review
Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease항염증성 microRNA-146a는 식이 유발 대사 질환으로부터 생쥐를 보호합니다Research Article Published on 2019-02-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adipose Adipose tissue Adiposity administration blockade blood glucose cellular cellular metabolism cellular respiration chronic inflammation Combination contribute Control controls creating Critical demonstrated develop Diabetic diabetic patient diabetic patients diet dysregulated Evidence expressed expression Factor fat genetics Glucose Glycolysis Human identifying Immune cell immune cells increase in Inflammation inflammatory function inflammatory gene inflammatory genes inflammatory pathways influence inhibitor Interaction investigated involved Macrophage macrophages mechanism metabolic disease metabolic pathway metabolic pathways metabolic processe metabolic processes metabolism mice microRNA miR-146 miRNA mTOR NF-κB NF-κB activation obese obesity pathway phenotype Phenotypes potential therapeutic target Prevent Pro-inflammatory genes PROTECT protective role provide Rapamycin reduced regulate regulated Regulatory represse Research RNA-sequencing shown Symptom tissue tissue macrophage Traf6 weight gain wild-type [DOI] 10.1371/journal.pgen.1007970 PMC 바로가기 [Article Type] Research Article
Reduced monocyte and macrophage TNFSF15 /TL1A expression is associated with susceptibility to inflammatory bowel disease감소된 단핵구 및 대식세포 TNFSF15 /TL1A 발현은 염증성 장 질환에 대한 감수성과 관련이 있습니다Research Article Published on 2018-09-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Affect allele animal model animal models association assumption bowel breakdown cell type cell types characterized chronic chronic inflammation compromise condition contribute Crohn’s disease cytokine decreased expression determine disease disease risk ENCODE ENhance Ethnic groups Evidence expression expression measurement functional genetic change genetic loci Genetic variant Genome-wide association studies Genotype Gut Haplotype healthy volunteer Hypothesis IBD IBD loci Immune homeostasis immunopathology increase Inflammation Inflammatory bowel disease intestinal list locus lymphocyte Macrophage macrophage differentiation macrophages mechanism monocyte Monocytes murine model murine models over patients Peripheral blood peripheral blood monocytes persist polymorphism Polymorphisms predisposition pro-inflammatory promote protective role protein level protein levels question receptor regulated regulatory region required responsible risk risk allele RNA shown Signaling Stimulation subtype susceptibility T cell T cells TNF TNFSF15 ulcerative colitis upstream variant variety [DOI] 10.1371/journal.pgen.1007458 PMC 바로가기 [Article Type] Research Article
Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human ImmunityReview Article Published on 2014-02-142023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] allergen helminth IgE protective role Schistosoma mansoni [DOI] 10.3389/fimmu.2014.00061 PMC 바로가기 [Article Type] Review Article
Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate ProteoglycansResearch Article Published on 2011-08-222022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] ACE2 addition against SARS-CoV aggregation Analysis angiotensin-converting enzyme 2 binding binding site Cell cell entry cells Defense disease disrupt dose-dependent manner experiment functional Host host cell host cells Host immune response Infection inhibit inhibited inhibition inhibitory Interaction Invasion investigated involved lactoferrin neutrophil NK cell Pathogenesis prevented previous study protective role Proteoglycan pseudovirus pseudovirus infection receptor reported respiratory SARS-CoV severe shown Spike protein suggested sulfate Treatment [DOI] 10.1371/journal.pone.0023710 PMC 바로가기 [Article Type] Research Article
RNase L Mediated Protection from Virus Induced DemyelinationResearch Article Published on 2009-10-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence Affect alteration ameliorated Anti-viral antiviral activity antiviral molecules Apoptosis apoptotic cell apoptotic cells Author Brain Cell Central nervous system characterized CNS coronavirus Coronavirus infection Critical deficiency Degradation Demyelination dependent on early Encephalitis Evidence expression foci function Host IFN-α/β immune in viral Increased induced induction of apoptosis Infected Infection Infectious virus infiltrating inhibiting Intervention majority manifested mechanism Mediated mice microglia mitigate morbidity morbidity and mortality mouse hepatitis virus neurodegeneration neuronal infection neurotropic not affect pathology pathway phenotype prevented proinflammatory PROTECT protection protective role recent reduce reflected RL RNA RNA degradation RNase severity Spread sustained tissue tissue damage translation type I interferon unique variant viral control viral replication viral spread viral tropism virus without affecting [DOI] 10.1371/journal.ppat.1000602 PMC 바로가기 [Article Type] Research Article
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article