Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링Article Published on 2022-07-212022-09-11 Journal: Cardiovascular Diabetology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19 [DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19통합 혈장 단백질체 및 단일 세포 면역 신호 네트워크 시그니처는 경증, 중등도 및 중증 COVID-19를 구분합니다.Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] addition approach AUC Cell clinical manifestation clinical manifestations coronavirus Coronavirus 2019 COVID-19 COVID-19 progression COVID-19 severity CyTOF determinant dysregulation examination feature hallmark identify immune Immunophenotyping Inflammatory JAK/STAT Ligand MAPK mass cytometry Mild moderate mTOR NF-κB nuclear Olink Patient patients PBMC Peripheral blood phenotype phosphosignaling response plasma plasma protein plasma proteins proteomic proteomics response reveal SARS-CoV-2 severe COVID-19 Signaling single-cell stacked generalization. STAT therapeutic target therapeutic targets Treatment uninfected [DOI] 10.1016/j.xcrm.2022.100680 PMC 바로가기 [Article Type] Article
Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severityCOVID-19 질병 중증도와 관련된 대사 산물, 단백질 및 조직 기능 장애Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] age Analysis anatomical approach biochemical pathway Biochemical pathways biological processe biological processes blood count blood count test changes in Characteristics clinical information complete blood count conjunction contribute COVID-19 Critical disease disease severity dysfunction Factor functional Gender Genome Health Health status Host Infection information Injury Interaction investigated liver lung machine learning algorithm Machine learning algorithms metabolite metabolites metabolomics molecular mechanism molecular mechanisms outcome Patient patient data predict presenting symptom profiles progression Protein proteomics provide response significant enrichment systemic inflammation tissue Treatment treatment of COVID-19 unstructured data with COVID-19 [DOI] 10.1038/s41598-022-16396-9 PMC 바로가기 [Article Type] Article
Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19 Research Published on 2022-07-162022-10-05 Journal: Cell Death Discovery [Category] 치료기술, [키워드] affected antiviral response approach biological processe CD147 cell death changes in complex contribute Coronavirus disease 2019 correlated COVID-19 COVID-19 pathogenesis COVID-19 patient dataset deaths described differentially expressed disease severity experiment expression feature FIVE identify individuals Infection interferon nonsurvivors outcome Pathogenesis pathway patient cohort patients performed Platelet platelet activation Protein proteome proteomic proteomics response reveal SARS-CoV-2 sequenced Significant survivor the SARS-CoV-2 genome thrombosis translation viral replication [DOI] 10.1038/s41420-022-01122-1 [Article Type] Research
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage초기 단계에서 SARS-CoV-2에 감염된 Cynomolgus Macaque의 단백질체 및 대사체 특성 분석Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analyzed characterization COVID-19 COVID-19 infection cynomolgus macaque cynomolgus macaques Cytokines demonstrated dysregulated early infection early stage Efficacy effort feature Features immune immune response innate immune response lung tissue lung tissues lymphopenia macaque mechanism metabolomic profiling metabolomics moderate Moderate COVID-19 neutrophilia Pathogenesis pathogenic mechanism patients platelet activation proteomic proteomics SARS-CoV-2 SARS-COV-2 infection sera severe COVID-19 severe COVID-19 patients Stage Symptom the early stage. Therapeutics tissues Vaccine weakened [DOI] 10.3389/fimmu.2022.954121 PMC 바로가기 [Article Type] Article
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding Research Published on 2022-07-012022-10-05 Journal: Cell Discovery [Category] 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation adaptive Analysis cell count Cell migration Classifier complement Course COVID-19 COVID-19 patient enhanced exhibited IgG antibody Immunity Inflammation liver longitudinal metabolites metabolomics pathway Patient predict proteomics receptor Regulatory RNA SARS-COV-2 infection sera subset suppressed the patient Treg Viral load viral replication Viral RNA Viral RNA shedding [DOI] 10.1038/s41421-022-00441-y [Article Type] Research
Superimmunity by pan-sarbecovirus nanobodies범사르베코바이러스 나노바디에 의한 초면역Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activities against SARS-CoV best booster breadth broadly neutralizing nanobody camelid clade conserved correlated CP: Immunology distance domain effective epitope Epitopes Evolution facilitate FIVE flat flexible Immunity immunized immunology Infection inhalable bispecific nanobody PiN-31 mechanism median milliliter nanobody neutralization potency Neutralizing observé omicron pan-sarbecovirus neutralization proteomics RBD RBD surface Receptor binding residues sarbecovirus SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 variants super immunity. the SARS-CoV-2 V(H)H antibody [DOI] 10.1016/j.celrep.2022.111004 PMC 바로가기 [Article Type] Article
Saliva changes in composition associated to COVID-19: a preliminary studyCOVID-19와 관련된 타액 조성 변화: 예비 연구Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation ACTN4 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Anosmia antibody ANXA4 Asymptomatic CA6 can be used caused changes in clinical presentation Clinical presentations composed control group coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID 19 COVID-19 COVID-19 group diagnostic diagnostics disease Diseases downregulation dysgeusia FGB FIVE healthy healthy individual immune response involved Mild mild COVID-19 patient mild COVID-19 patients occur oxidative damage pathophysiology Patient patients patients with COVID-19 Perspective positive Potential biomarker potential biomarkers Protective Protein proteome proteomic study proteomics pulmonary tissue quantification respiratory complication Respiratory complications RT-PCR Saliva saliva samples salivary SARS-CoV 2 separated severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 stimulus taste perception tested TGM3 the disease tissue Treatment two groups upregulation variety viral infection virus [DOI] 10.1038/s41598-022-14830-6 PMC 바로가기 [Article Type] Article