Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
Biological Sciences
[키워드] ACE2
ACE2 receptor
ACE2 variant
acute respiratory syndrome
addition
Affinity maturation
amino acid change
Angiotensin-converting enzyme
antibody
antiviral therapeutics
approach
authentic SARS-CoV-2 virus
backbone
binding
cells
computational design
convalescent patient
Convalescent patients
coronavirus
Coronaviruses
COVID-19 pandemic
domain
entry receptor
faster
flexible
generate
half-maximal inhibitory concentration
host cells
human immunoglobulin
IC50s
impair
inactivated
Infection
infections
lentivirus
mechanism
mutations
neutralize
neutralized
neutralizing antibody
offer
other coronavirus
Prevent
Protein
random mutagenesis
RBD
receptor
Receptor binding
Receptor binding domain
receptor protein
receptor trap
respiratory diseases
SARS-CoV-1
SARS-CoV-2
SARS-CoV-2 entry
SARS-COV-2 infection
Seven
Significance
the RBD
therapeutic response
treat
variant
viral entry
viral escape
Viral resistance
viral spike protein
virus
wild-type
yeast
yeast display
[DOI] 10.1073/pnas.2016093117 PMC 바로가기 [Article Type] Biological Sciences
[DOI] 10.1073/pnas.2016093117 PMC 바로가기 [Article Type] Biological Sciences