Respiratory distress syndrome – Page 17 – Communicable Diseases Research

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

데드 스페이스 추정치는 COVID-19 ARDS의 28일 사망률과 독립적으로 연관되지 않을 수 있습니다.

Observational Study

Published on 2021-05-172022-09-11
Journal: Critical Care [Category] 바이오마커, 임상,

SARS-CoV-2 antibody immunoassays in serial samples reveal earlier seroconversion in acutely ill COVID-19 patients developing ARDS

일련의 샘플에서 SARS-CoV-2 항체 면역 분석 결과 ARDS가 발병하는 급성 COVID-19 환자에서 조기 혈청 전환이 나타남

Research Article

Published on 2021-05-132022-09-12
Journal: PLoS ONE [Category] SARS, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome anti-SARS-CoV-2 Antibody testing ARDS ARDS patient ARDS patients clinical evaluation Cohort cohorts conducted COVID-19 pandemic COVID-19 patient determine diagnostics Disease prevalence Elecsy Elecsys ELISA Germany healthy subject IgA IgG immunoassay individual Lubeck marker objective occurred Patient patients PCR-negative Population potential risk Rate respiratory distress Respiratory distress syndrome Result risk marker Roche Diagnostics SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody testing sensitivities Seroconversion serum side significantly higher Specificities specificity specimen stratified suggested Switzerland syndrome tested therapeutic utility were measured were used
[DOI] 10.1371/journal.pone.0251587 PMC 바로가기 [Article Type] Research Article

COVID-19’s natural course among ambulatory monitored outpatients

외래 모니터링 외래 환자의 COVID-19 자연 경과

Observational Study

Published on 2021-05-122022-09-10
Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술,

[키워드] Ageusia Algorithm Anosmia Asymptomatic average Cohort Comorbidities Complication Course COVID-19 symptom diagnosed diagnostics disease Epidemiology evaluated fevers Follow-up Genetic testing Government group highest highlight Hospitalized indicated initial symptom Intensive Lifestyle modification mass education median medical condition modify negative sample negative test no symptom no symptoms occurred Outpatient outpatients Patient Patient education patients PCR PCR negativity Population screening Preventive medicine proliferation quarantine Regulation reported respiratory Respiratory distress syndrome Respiratory signs and symptoms Risk factors SARS-CoV-2 significantly subsequent Symptom symptom onset symptom status symptomatic Symptoms the disease trajectory Variability Viral viral infection Viral load
[DOI] 10.1038/s41598-021-89545-1 PMC 바로가기 [Article Type] Observational Study

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다

Research Article

Published on 2021-05-122022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread
[DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article

Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era

코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점

Review

Published on 2021-05-122022-09-12
Journal: Stem Cell Research & Therapy [Category] SARS, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular
[DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

초기 인간 항-SARS-CoV-2 IgG의 높은 역가 및 낮은 푸코실화는 폐포 대식세포에 의한 염증을 촉진합니다

Research Article

Published on 2021-05-112022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response addition alveolar alveolar macrophage Alveolar macrophages anti-SARS-CoV-2 IgG Anti-spike anti-Spike IgG anti-spike protein IgG antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokines dependent on diagnosed disease driven by early phase Evidence excessive inflammatory response Fcγ receptor FcγR FDA feature fostamatinib glycosylation hallmark human macrophage IgG IIa in vitro induce infection with SARS-CoV-2 Inflammation Inflammatory response inhibitor initial interleukin interleukin-6 intrinsically Macrophage macrophage activation macrophages Microvascular thrombosis Necrosis occur Patient pro-inflammatory promote promote inflammation pulmonary endothelial receptor respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 second Seroconversion serum severe COVID-19 severe disease small molecule Spike protein syndrome therapeutic thrombosis Tumor tumor necrosis tumor necrosis factor was normalized worsening
[DOI] 10.1126/scitranslmed.abf8654 PMC 바로가기 [Article Type] Research Article

Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19

COVID-19 환자를 위한 HDAC 억제제 발프로산의 잠재적인 용도 변경

Review

Published on 2021-05-052022-09-11
Journal: European journal of pharmacology [Category] SARS, 신약개발,

[키워드] acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect cellular coronavirus disease Coronavirus-2 COVID-19 cytokine response distress drug Effect end-organ damage enzyme epilepsy expression HDAC HDAC inhibitor histone Histone deacetylase inhibitor immune Infection inhibitor mitigate modulate Patient patients with COVID-19 Potential Prevent reduce reducing required respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 viral Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic Therapeutic approach therapeutic approaches therapeutic target therapy transmembrane serine protease transmembrane serine protease 2 Valproic acid Valproic acid.
[DOI] 10.1016/j.ejphar.2021.173988 PMC 바로가기 [Article Type] Review

The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients

성인 인도네시아 환자에서 COVID-19 진단을 위한 항문 면봉 RT-PCR의 가치

Observational Study

Published on 2021-05-012022-09-11
Journal: BMJ open gastroenterology [Category] SARS, 임상, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome Anal anal swab analysed Analysis anorexia Chain Reaction collected conducted COVID-19 COVID-19 diagnosis COVID-19 patients diagnostic diagnostic investigation diagnostic test diagnostic virology. Gastrointestinal symptom gastrointestinal symptoms hospitalised Hospitalised patients Indonesia Laboratory mild cases Mitra nasopharyngeal Nasopharyngeal swab nasopharyngeal swab PCR nausea Negative predictive value Patient PCR test polymerase chain polymerase chain reaction positive positive result Predictive value remained respiratory distress Respiratory distress syndrome reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 antigen SARS-CoV-2 RNA detection sensitivity Sensitivity and specificity specificity specimen subgroup of patient subject Swab syndrome
[DOI] 10.1136/bmjgast-2020-000590 PMC 바로가기 [Article Type] Observational Study

Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls

Multicenter Study

Published on 2021-05-012023-07-12
Journal: American journal of obstetrics and gynecology [Category] SARS,

[키워드] coronavirus Critical disease disease course intensive care intubation Maternal morbidity pandemic Pregnancy Preterm birth Respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe disease
[DOI] 10.1016/j.ajog.2020.11.022 PMC 바로가기 [Article Type] Multicenter Study

Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

면역 체계 강화에 Nagella sativa(블랙 커민)의 잠재적인 영향: COVID-19 전염병을 늦추기 위한 희망

Review

Published on 2021-05-012022-08-31
Journal: Phytomedicine : international journal of phytother [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory distress syndrome Anti-inflammatory antioxidant ARDS benefit black Black seed component components coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical Cytokines disease severity Effect Evidence FDA approved Drugs human body immune immune modulation immune regulation immune response immune system immunomodulation indicated infected with COVID-19 intensive care intensive care unit modulation molecular molecular docking Molecular docking study Mortality Nagella sativa New coronavirus Nigella Sativa Nigellidine Obstructive pandemic pathophysiology Patient Potential pro-inflammatory cytokine pro-inflammatory cytokines provided respiratory respiratory disorders respiratory distress Respiratory distress syndrome severe cases severity Symptom the disease thymoquinone treat Treatment Vaccine α-hederin α-hederin.
[DOI] 10.1016/j.phymed.2020.153277 PMC 바로가기 [Article Type] Review