Genetic Diversity of Spike, 3a, 3b and E Genes of Infectious Bronchitis Viruses and Emergence of New Recombinants in KoreaArticle Published on 2013-01-312022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Cluster Clustering coding region conducted determined Diversity E gene emergence FIVE Gene genetic diversity Genotype genotypes IBV Infectious Bronchitis Virus Infectious bronchitis virus (IBV) information insertion isolate mass Molecular epidemiology New not found nucleotide nucleotide sequence Phylogenetic Phylogenetic analysis Phylogenetic tree prevalent recombinant recombinants Recombination S gene sequence similarity spike Vaccine virus viruses [DOI] 10.3390/v5020550 PMC 바로가기 [Article Type] Article
A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 SerotypeResearch Article Published on 2011-08-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence backbone Belonging Clinical sign Clinical signs defined different ectodomain effective expressing Genetic Heterologous homologous IBV Infected M41 observation pathogenic pathogenicity qRT-PCR recombinant removed RNA S gene serotype shown spike the S protein the spike protein Trachea Vaccines virus wild type [DOI] 10.1371/journal.pone.0024352 PMC 바로가기 [Article Type] Research Article
The Replicase Gene of Avian Coronavirus Infectious Bronchitis Virus Is a Determinant of PathogenicityResearch Article Published on 2009-10-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accessory gene avirulent cell tropism Complete demonstrated determinant dominant Genome IBV in vitro Infectious Bronchitis Virus M41 pathogenicity replaced replicase S gene virulence virulent virus [DOI] 10.1371/journal.pone.0007384 PMC 바로가기 [Article Type] Research Article
Acquisition of Cell–Cell Fusion Activity by Amino Acid Substitutions in Spike Protein Determines the Infectivity of a Coronavirus in Cultured CellsResearch Article Published on 2009-07-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid acquisition activity Amino acid bronchitis Cell cell line cells chimeric cloned compensatory mutation coronavirus cultured cell cultured cells determine determined ENhance expression fusion heptad repeat Host host cell IBV infectious Infectivity Interaction introduced kidney membrane fusion Mutation Point mutation Protein Region required responsible S gene S protein S1 domain shown site-directed mutagenesis specificity spike strain Substitution syncytia formation the S protein variant Vero Vero cells viral spike [DOI] 10.1371/journal.pone.0006130 PMC 바로가기 [Article Type] Research Article
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal VaccinationResearch Article Published on 2009-01-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen Chinese dissemination doses Efficacy experiments generate genomic location Head-to-head comparison implication Inducing inoculated intramuscular intranasal Level maintain mice mucosal neutralizing antibody novel offer Prevent protective immune response response S gene SARS-CoV SARS-CoV neutralizing antibody spike glycoprotein Superior Tian vaccination Vaccine vaccine candidate vaccinia variant vector Viral transmission Viral vector was used wild-type [DOI] 10.1371/journal.pone.0004180 PMC 바로가기 [Article Type] Research Article
Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groupsResearch Article Published on 2006-10-042022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] acute respiratory syndrome adaptive addition Amino acid changes in characterized contribute coronavirus Course CoV detected different domain Epidemic epidemiological Evolution found greater group groups heptad repeat hosts human host humans membrane fusion occurred outbreak Phylogenetic tree positive Positive selection proportion Protein RBD receptor residue Result reveal S gene S protein SARS-CoV selected selective selective pressure selective sweep spike gene strain subsequent the S protein Transmission two group two groups Variation viral adaptation [DOI] 10.1186/1471-2180-6-88 PMC 바로가기 [Article Type] Research Article
SARS-CoV Infection in a Restaurant from Palm CivetResearch Published on 2005-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis China circulation Civet contact with coronavirus gene sequence Guangzhou, China isolates palm civet palm civets Partial Patient positive related Research restaurant S gene SARS-CoV SARS-CoV infection Severe acute respiratory syndrome transfer viral sequence [DOI] 10.3201/eid1112.041293 PMC 바로가기 [Article Type] Research
A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in BelgiumResearch Article Published on 2005-02-012022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 2003 229E Analysis Belgium children collected coronavirus diagnosed evaluated HCoV-229E HCoV-NL63 HCoV-OC43 Hospitalized human coronavirus incidence infect Infection isolate Netherland NL63 OC43 positive sample Respiratory disease respiratory symptom respiratory tract infection Result RT-PCR RT-PCR assay S gene Sample SARS-CoV sequence subtype Support [DOI] 10.1186/1471-2334-5-6 PMC 바로가기 [Article Type] Research Article
Molecular analysis of S gene of spike glycoprotein of winter dysentery bovine coronavirus circulated in Korea during 2002–2003Short Communication Published on 2004-08-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Amino acid Analysis analyzed avirulent Bovine coronavirus Characteristics compared conducted coronavirus strain country diarrhea French Genetic Genetic characteristics glycoprotein homologous isolate Korean molecular analysis nucleotide Phylogenetic analysis related S gene S glycoprotein sequence significantly spike glycoprotein strain Strains the S1 subunit [DOI] 10.1016/j.virusres.2004.07.003 PMC 바로가기 [Article Type] Short Communication