Toll-like Receptor 1 N248S Single-Nucleotide Polymorphism Is Associated With Leprosy Risk and Regulates Immune Activation During Mycobacterial InfectionToll-like 수용체 1 N248S 단일 염기 다형성은 레프로지 위험과 결핵균 감염 중의 면역 활성을 조절한다.journal-article Published on 2013-07-012024-08-01 Journal: Nanoscale [Category] 한센병, [키워드] cytokine IL-10 leprosy N248S SNPs TLR1 TNF [DOI] 10.1093/infdis/jit133 [Article Type] journal-article
Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic DermatitisGerman Shepherd Dogs의 게놈 전체 분석을 통해 아토피 피부염과 CFA 27에 대한 유전자좌 연관성 밝혀Research Article Published on 2013-05-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected age allergic skin Analysis association atopic dermatitis Author block blocks CAD canine caused CFA chromosome Cohort compared complex contributing to Control correlation defined dermatitis detected develop different disease Disease prevalence division dog eight environmental factors expressed found Genes Genetic genetics Genome genome-wide association genome-wide significant genotyping German shepherd GSD Haplotype high correlation Human IgA level IgA levels included indicate Interaction mixed model approach parameters performed PKP2 plakophilin population stratification Prevalence sampling separation Sequencing serum significantly significantly lower skin disease SNPs study population subpopulation subpopulations subset Swedish the strongest was performed was used [DOI] 10.1371/journal.pgen.1003475 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)게놈 전체에 걸친 통합 게놈 연구는 엡스타인-바 바이러스 핵 항원 1(EBNA-1)에 대한 항체에 영향을 미치는 유전적 요인을 국소화합니다.Research Article Published on 2013-01-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Adult adverse outcome adverse outcomes Analysis antibody antibody levels Antigen approach association Author Autoimmune disorders best Burkitt lymphoma Cancer cancers Candidates chromosome chromosome 6 concerning dataset disease Disease progression DQB1 DRB1 EBV Epstein Barr virus Epstein-Barr virus Evidence evidence of examined expression data Factor family members focus foreign antigen foreign antigens found Gene Gene Expression Genetic genetic factors Genome HLA HLA locus HLA-DQB1 HLA-DRB1 Hodgkin lymphoma Host human leukocyte antigen IgG antibodies IgG antibody immune function immune system independent individual infect Infected Infection infectious Infectious disease infectious mononucleosis investigated involved joint leukocyte linkage loci locus lupus erythematosus lymphocyte lymphoproliferative disorders malignancies malignancy measure mechanism MHC class MHC class II multiple sclerosis nasopharyngeal lymphoma not found nuclear overlap P -value pathogen Pathogens prevalent provide regulate related replicated Research severe complication severe complications severe disease significantly SNP SNPs susceptibility susceptibility loci systemic lupus erythematosus T cells virus was obtained [DOI] 10.1371/journal.pgen.1003147 PMC 바로가기 [Article Type] Research Article
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary FunctionSNP 및 SNP-by-Smoking 상호 작용의 게놈 전체 공동 메타 분석은 폐 기능에 대한 새로운 유전자좌를 식별합니다Research Article Published on 2012-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis applied association Author Autoimmune cigarette smoking compared complex conducted demonstrated differential expression DNER DQB1 Effect Effects European evaluated Evidence evidence of expiratory expressed FEV forced expiratory volume forced vital capacity found function Gene gene region Genetic genetic loci genetic risk factor Genome-wide association studies Genome-wide association study highlight HLA region HLA-DQA2 HLA-DQB1 Human airway epithelium human lung tissue identify implicated Interaction involved joint KCNJ2 loci lung Lung disease measure Meta-analysis meta-analysis model novel nucleotide Phenotypes polymorphism progression pulmonary Pulmonary function Region regions related shown single nucleotide Single nucleotide polymorphism smoker Smokers smoking SNP SNPs SOX9 study participant trait utility vital capacity Volume [DOI] 10.1371/journal.pgen.1003098 PMC 바로가기 [Article Type] Research Article
The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition GrooveHLA 클래스 I 항원 인식 그루브와 관련된 중국 비인두암의 주요 유전적 결정인자Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele allele frequencies alleles Amino acid Analysis analyzed antigens association associations Author binding Cancer carcinoma carried China Chinese chromosome chromosome 6 class Cohort concert dependent on detect detected determinant disease driven by EBV epithelial Epstein-Barr virus examined facilitated GABBR1 Gene gene region genetic influence Genome-wide association study Groove Guangdong Guangxi GWAS HCG9 help High-resolution HLA HLA alleles HLA class I HLA class I gene HLA region HLA-A HLA-A and -B HLA-B HLA-F incidence independent Infection influences influences on Interaction involved large cohort Linkage disequilibrium malignancy molecular motif multivariate Nasopharyngeal carcinoma NPC nucleotide operative OR2H1 over peptide performed physically principal Recognition recognize Region regression analysis replicate Replication resolved risk second sequence SNP SNPs statistical study participant the major histocompatibility the strongest variant variants virus infection [DOI] 10.1371/journal.pgen.1003103 PMC 바로가기 [Article Type] Research Article
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci6개의 1형 당뇨병 코호트에 대한 게놈 전체 메타 분석으로 여러 관련 유전자좌 식별Research Article Published on 2011-09-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADCY3 affected association Author C6orf120 CENPO chromosomal combined cohort contributing to controls dataset diabete diabetes disease DLL1 DNAJC27 DNMT3A domain EFR3B examined excess FAM120B Follow-up Gene gene network gene networks Genes Genetic genetic component genetic loci genetic screening Genome Genome-wide association studies Genome-wide association study genome-wide significance genotyped GWAS homolog hypotheses identify Impact independent intergenic region intronic region investigator investigators Linkage disequilibrium LMO7 LOC154449 loci meta-analyses Meta-analysis Multiple NCOA1 Pathogenesis PHF10 POMC Protein PSMB1 reached recent finding Region replicated risk risk for disease significantly SNP SNPs susceptibility T1D TBP the disease Type Type 1 diabetes variant variants WDR27 [DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성Research Article Published on 2011-05-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants [DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article