Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
A Continuous Markov-Chain Model for the Simulation of COVID-19 Epidemic DynamicsArticle Published on 2022-01-262022-10-28 Journal: Biology [Category] COVID-19, [키워드] addition antibodies applied approach basic reproduction number Characteristics Contact Continuous Coverage COVID-19 COVID-19 epidemic demonstrated distribution Dynamics Effect Epidemic Evidence explain Factor Frequency Guidance Herd immunity threshold hotspot Human Immunity indicate individual Infection Markov-chain model Misconception Model Mutation natural immunity predict predicted Probability Reproduction number SARS-CoV-2 significantly significantly higher simple Simulation Spread spread of COVID-19 statistical Support Taking tested the epidemic threshold vaccination Variation virus [DOI] 10.3390/biology11020190 PMC 바로가기 [Article Type] Article
Association of Convalescent Plasma Treatment With Clinical Status in Patients Hospitalized With COVID-19 A Meta-analysisResearch Published on 2022-01-252022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] accumulated Administered age analyzed antibody association baseline baseline characteristics benefit CCP clinical Clinical outcome clinical trial clinically convalescent plasma covariates COVID-19 CrI cumulative death determine Efficacy enrolled Evidence extraction feasible finding greater hospitalized patient Importance International international organization IQR Local Logistic measure mechanical ventilation median Meta-analysis MONITOR monitoring board Mortality National objective outcome pandemic participant Participants Patient patient data Point posterior probability Primary outcome randomization Randomized randomized clinical trial real time receiving Relevance required Research resource Result robust secure Selection Source statistical status submitted synthesis treat Treatment effect size treatment for COVID-19 Trial was performed WHO with COVID-19 women World Health Organization [DOI] 10.1001/jamanetworkopen.2021.47331 PMC 바로가기 [Article Type] Research
Social innovation based on collaboration between government and non-governmental organizations in COVID-19 crisis: evidence from IranResearch Article Published on 2022-01-252022-10-29 Journal: Infectious Diseases of Poverty [Category] Coronavirus, SARS, [키워드] affecting Analysis can be used Collaboration with non-governmental organizations collected data component Consequences COVID-19 COVID-19 pandemic education Effect effective Effectiveness eight Evidence executive Existence facilitate Factor Government Health home identify implementation initial Intervention Iran lesson Ministry of Health organization problem Qualitative approach reducing Research respond Result shown Social innovation Social policy statistical Structure theory was obtained was used widespread [DOI] 10.1186/s40249-021-00923-3 PMC 바로가기 [Article Type] Research Article
Surveillance Web System and Mouthwash-Saliva qPCR for Labor Ambulatory SARS-CoV-2 Detection and Prevention분만 이동 SARS-CoV-2 감지 및 예방을 위한 감시 웹 시스템 및 구강 세척제-타액 qPCRArticle Published on 2022-01-242022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 치료기술, 치료제, [키워드] Algorithm Alpha Alpha variant ambulatory applied Asymptomatic baseline Community conducted copy number coronavirus COVID-19 database Decision-making detection Detection limit development effective epidemiological epidemiological surveillance Evidence evidence of Follow-up house individual labor Laboratory Mild moderate monitoring Mouthwash N-gene nasopharyngeal swabbing platform populations prevention primer Primers protocol provide provided qPCR RT-qPCR RT-qPCR test Safe SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 testing sensitivity specificity specimen statistical Surveillance symptomatic symptomatic case System threshold Viral virus virus inactivation volunteers Web work environments [DOI] 10.3390/ijerph19031271 PMC 바로가기 [Article Type] Article
IDEAS: individual level differential expression analysis for single-cell RNA-seq dataMethod Published on 2022-01-242022-11-01 Journal: Genome Biology [Category] Coronavirus, [키워드] Analysis collected Control COVID-19 patient differential expression differentially expressed distribution expression gene expression difference IDEAS increasingly individual individual level individuals Mild Patient question scRNA-seq severe symptoms single-cell RNA-seq statistical Study design supplementary material two group [DOI] 10.1186/s13059-022-02605-1 PMC 바로가기 [Article Type] Method
Study of Clinical Outcome and Healthcare Modalities of COVID-19 Patients Treated With Remdesivir at a Tertiary Care Teaching HospitalInfectious Disease Published on 2022-01-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI 95% confidence interval Administered age All the patient analyzed approved assisted ventilation association Care Characteristics clinical Clinical outcome clinical outcomes Comorbidities Comorbidity conducted coronavirus country COVID-19 COVID-19 patient determine diabete difference Factor Gender Health health care modalities healthcare hospital hypertension Infection intravenously material modality number of comorbidity Odds ratio Oxygen requirement Patient patients protocol released Remdesivir required Result Retrospective study statistical statistically significant Still Teaching Tertiary the mean treated Treatment treatment for COVID-19 younger patient [DOI] 10.7759/cureus.21535 PMC 바로가기 [Article Type] Infectious Disease
National COVID-19 Vaccine Program and Parent’s Perception to Vaccinate Their Children: A Cross-Sectional StudyArticle Published on 2022-01-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition Adults Anxiety children correlation COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine decrease Effectiveness event female Gender Google had no Health Immunity infected with COVID-19 information knowledge male media parent parent willingness participant Participants Perception Prevent Program public health questionnaire random required Safety Sample size Saudi Arabia statistical statistically significant Stress the vaccine Vaccinating vaccination vaccination of children Vaccine [DOI] 10.3390/vaccines10020168 PMC 바로가기 [Article Type] Article
ABO blood grouping and COVID-19: a hospital-based study in Eastern IndiaResearch Published on 2022-01-202022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 95% CI ABO ABO blood grouping ABO blood type ACE acute respiratory syndrome addition age analyzed antibody association Blood Blood Group Cell control group controls coronavirus coronavirus disease COVID COVID 19 COVID-19 Critical care disease disease severity enzyme experimental model groups Hepatitis higher risk highest Host ICU admission in viral India Infection inhibit Interaction involved Microsoft Excel outbreak Pathogenesis Patient polymerase chain positive positive patient Prevalence Previous studies qRT-PCR Quantitative Real-time PCR receptor recorded Result Retrospective study risk factor SARS-CoV2 severity shown statistical susceptibility viral disease Viral load virus [DOI] 10.1186/s43042-022-00225-9 PMC 바로가기 [Article Type] Research
Performance of Three Tests for SARS-CoV-2 on a University Campus Estimated Jointly with Bayesian Latent Class ModelingResearch Article Published on 2022-01-192022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Accuracy acute respiratory syndrome Antigen applied approach Bayesian bayesian statistics Campus circumvent class collected coronavirus COVID-19 COVID-19 pandemic CrI Critical Diagnosis effective effort Epidemiology estimate Estimated gold standard inaccuracy individual involved Latent latent class less median modeling molecular diagnostic molecular test Molecular tests Nasal sample performance performed Prevent public health surveillance reverse transcriptase PCR RT-PCR RT-PCR testing RT-PCR tests Saliva Sample size SARS-CoV-2 SARS-CoV-2 transmission sensitivity specificity Spread statistical Surveillance Test Testing university variety virus [DOI] 10.1128/spectrum.01220-21 PMC 바로가기 [Article Type] Research Article