A novel statistical method predicts mutability of the genomic segments of the SARS-CoV-2 virusResearch Article Published on 2022-12-132022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] affected antiviral drugs approach candidate coding regions codon conserved correlated correlation determine develop disease distribution effective epitope Frequency genomic identify immunogenic peptide large-scale analysis mutability offer overcome pandemic pathogenesis of SARS-CoV-2 predict predicted Protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 scientist sequence Seven spike glycoprotein statistical statistical analysis target the SARS-CoV-2 virus treatments for COVID-19 Vaccine viral genome viral mutation whole genome whole genome sequence Word Ranking [DOI] 10.1017/qrd.2021.13 PMC 바로가기 [Article Type] Research Article
Spatiotemporal pattern recognition and dynamical analysis of COVID-19 in Shanghai, ChinaArticle Published on 2022-12-072022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Autocorrelation analysis China COVID-19 COVID-19 disease Daily Daily reproduction number diffusion disease dissemination dynamic Dynamic model early stage Effect hotspot IMPROVE mutant omicron outbreak provided retrospective SARS-CoV-2 transmission Shanghai Spatial statistics. spatiotemporal statistical suffered suppress the epidemic [DOI] 10.1016/j.jtbi.2022.111279 PMC 바로가기
Beyond COVID-19: Do biothermodynamic properties allow predicting the future evolution of SARS-CoV-2 variants?Research article Published on 2022-12-012022-10-05 Journal: Microbial Risk Analysis [Category] 변종, [키워드] Analysis binding biological property changes in COVID-19 pandemic driving Epidemiological study Evolution Evolution of SARS-CoV-2 Gibbs energy of binding Gibbs energy of growth growth Mechanistic model MERS-CoV Mutation new strain new virus Occurrence pandemic parameter performed predict risk SARS CoV-2 SARS-CoV statistical Strains the SARS-CoV-2 variants of SARS-CoV-2 Virus-host interaction viruses [DOI] 10.1016/j.mran.2022.100232 [Article Type] Research article
Inferring the true number of SARS-CoV-2 infections in JapanArticle Published on 2022-11-012022-11-16 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 변종, [키워드] adjusted Adults approach can be used Case counts Characteristics component conducted COVID-19 COVID-19 infection death distributions Effect epidemiological estimate fatality Health IFR Infection Infection fatality rates infections Japan laboratory-confirmed Measures Meta-analysis Mild pandemic Pharmaceutical interventions provide reported SARS-CoV-2 SARS-COV-2 infection statistical subclinical infection Surveillance Under-ascertainment. vaccination variants [DOI] 10.1016/j.jiac.2022.08.002 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
Sars-Cov2 world pandemic recurrent waves controlled by variants evolution and vaccination campaignArticle Published on 2022-10-272022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis component country dominant epidemic wave Evolution fatality Frequency indicate Infection information interval intrinsic Japan pandemic Quantitative statistical subsequent the epidemic United Kingdom United States USA vaccination variant variants Variation while [DOI] 10.1038/s41598-022-22816-7 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Interpreting global variations in the toll of COVID-19: The case for context and nuance in hypothesis generation and testingArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] affecting aggregate aggregates Analysis analyzed benefit Biomarker Biomarkers cause-specific mortality country covariate COVID COVID-19 COVID-19 pandemic database domain domains driver ecological events extension Factor Factors flexible Health health economics Health policy Hypothesis Interaction interactions Interpreting Isolation joint Lifestyle factors machine learning morbidity National obesity OLS omicron outcome outcomes pandemic Policy Population populations potential risk response SARS-CoV-2 socioeconomics statistical statistical methods. These data variant variants Variation while [DOI] 10.3389/fpubh.2022.1010011 PMC 바로가기
Quantifying Mutational Response to Track the Evolution of SARS-CoV-2 Spike Variants: Introducing a Statistical-Mechanics-Guided Machine Learning MethodArticle Published on 2022-10-132022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied Affect Analysis approach average binary classification model characteristic concern Critical database defined Evolution function global public health help identify implication information interest machine learning Mutation mutations pathogenicity predict residue response SARS-CoV-2 sequence spike spike glycoprotein Stage statistical track variant virus VoC VOCs VOIs [DOI] 10.1021/acs.jpcb.2c04574 PMC 바로가기
Local monitoring of SARS-CoV-2 variants in two large California counties in 2021Article Published on 2022-10-112022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Advarra Alpha variant analyzed approved carried caused changed changes in Cohort conducted confidence interval coronavirus COVID-19 Cycle threshold value Delta delta variant effort enrolled Enrollment Epidemiology genomic data Hispanic identify individual institutional review board Laboratory less Los Angele MONITOR Mutation nare nasal offered Older over participant Participants PCR polymerase chain positive Positive test Prevalence proportion public health resulting Sample SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 strain SARS-CoV-2 testing SARS-CoV-2 variant Sequencing sequencing data Spanish specimen specimens statistical study enrollment study period Surveillance swab specimen Symptom tested transported variant variants of concern women [DOI] 10.1038/s41598-022-21481-0 PMC 바로가기