Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory ApproachArticle Published on 2022-01-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Alpha variant analyses Analysis assigned assumed Beta bioinformatic validation COVID-19 COVID-19 pandemic COVID-19 variants demonstrated Gamma greater identify Lineage Mutation mutations N gene N501Y PCR Rapid Reactions reliability S gene Sanger sequencing SARS-CoV-2 SARS-CoV-2 virus selected SNP spike Spread statistical unique variant variants weight whole-genome sequencing [DOI] 10.3390/v14010123 PMC 바로가기 [Article Type] Article
Genome Sequencing Reveals a Mixed Picture of SARS-CoV-2 Variant of Concern Circulation in Eastern Uttar Pradesh, IndiaMedicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affected Amino acid Analysis analyzed approach AY.1 Breakthrough infection change clade Complete concern conserved coronavirus COVID-19 COVID-19 breakthrough infection COVID-19 disease death Delta delta variant Eastern Uttar Pradesh India Effect Evolution First wave Genome genomic highest India introduced Lineage Mutation mutations predominant recorded reported SARS-CoV-2 second wave sequenced Sequencing signature specific mutations Spike protein the SARS-CoV-2 genome Transmission unique Vaccine variant variant of concern variants of concern virus VOCs WGS whole-genome sequencing Wuhan isolate [DOI] 10.3389/fmed.2021.781287 PMC 바로가기 [Article Type] Medicine
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of ConcernSARS-CoV-2 변이체의 신속하고 민감한 스크리닝을 위한 증폭 불응 돌연변이 시스템-정량적 역전사-PCR 분석법 개발Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha alpha and delta variants amplification analyzed application ARMS ARMS-RT-qPCR B.1.617.2 clinical sample clinical samples concern concerning conserved conserved unique mutation coronavirus Delta delta variant Delta variants demonstrated detect develop Developing fluorescent Genome genomes Genomic analysis GISAID hospital Laboratory Lineage lineages Molecular assay Molecular diagnosis Mutation network organizations pandemic PCR position Quantitative quantitative reverse transcription-PCR Rapid reagent reagents refractory respiratory reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Screening sensitive sequencing-based methods severe acute respiratory syndrome Coronavirus Spread target Transmission unique variant variants of concern VoC VOCs whole-genome sequencing [DOI] 10.1128/spectrum.01438-21 PMC 바로가기 [Article Type] Research Article
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain)SARS-CoV-2와 함께하는 1년: 바르셀로나 시(스페인 카탈로니아)에서 전체 게놈 시퀀싱을 통한 바이러스 계통 순환의 역학 개요Coronaviruses Published on 2022-01-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] age antigenic B.1.1 B.1.1.7 B.1.177 B.1.351 B.1.617.2 Barcelona Catalonia circulating circulation clinical setting Complete consensus sequence consensus sequences COVID-19 D614G mutation E484K epidemiological events Genetic genetic diversity genetic variability GISAID hospital Illumina immunological L452R Lineage lineages MiSeq Molecular epidemiology Multiple Mutation N-terminal domain P.1 pandemic predominant primary care protocol Randomly Receptor-binding domain respiratory respiratory sample S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 virus selected sequenced Spain T478K the receptor-binding domain the S protein vaccination variants viruses was performed were used WGS while whole-genome sequencing [DOI] 10.1080/22221751.2021.2011617 PMC 바로가기 [Article Type] Coronaviruses
Investigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School독일 중등 학교에서 제한적이고 폭발적인 Covid-19 발병 조사Article Published on 2022-01-042022-09-10 Journal: Viruses [Category] SARS, 치료기술, [키워드] Adults Aerosols Analysis cause causes children Cluster condition connection Contact Course COVID-19 disadvantage Disadvantages epidemiological epidemiologically examined Explosive family members Germany Hamburg index case Infection infection chain investigated investigation Laboratory Limited Lineage Mask measure member MOST Non-pharmaceutical interventions occurred open opening outbreak parameter Prevent respiratory SARS-CoV-2 School school outbreak Schools secondary secondary school Sequence analysis similarity source of infection superspreading event took place Transmission virus virus genome were infected WGS whole-genome sequencing [DOI] 10.3390/v14010087 PMC 바로가기 [Article Type] Article
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study우려의 알파(B.1.1.7) 변종과 비교한 SARS-CoV-2 델타(B.1.617.2)에 대한 입원 및 응급 치료 출석 위험: 코호트 연구Comparative Study Published on 2022-01-012022-09-10 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 변종, 치료기술, [키워드] adjust adjusted adjusted hazard ratio Admission age Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 both groups Care Cohort cohort study Cox regression data set dataset death delta variant Department Deprivation Digital dominant Emergency Emergency Care England Ethnicity finding funding Generation greater health-care health-care service health-care services hospital Hospital admission immunisation Innovation International lead Lineage median age Medical Research Council Mortality Most patient Most patients National NHS outbreak outcomes Patient patients with COVID-19 Precision predominant Public Health England Relative risk residence Result risk SARS-CoV-2 delta SARS-CoV-2 variant second secondary Sequencing service severe disease severity Sex specimen Stratified Cox regression subgroups System Transmissibility Travel unvaccinated population unvaccinated populations vaccination Vaccination Status variant was done was used whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00475-8 PMC 바로가기 [Article Type] Comparative Study
The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 OutbreaksMajor Articles and Brief Reports Published on 2022-01-012022-10-29 Journal: The Journal of Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Admission affected Analysis Asymptomatic classical Cluster Community contributed controlling coronavirus epidemic wave epidemiological data Epidemiology events excluded Genetic epidemiology high-risk area hospital identify Impact incidence Infection infection control Infection prevention initial instance Intervention measure Measures nosocomial Nosocomial transmission outbreak pandemic Patient point-of-care resource resources SARS-CoV-2 Sequencing significantly Transmission viral sequence virus WGS whole-genome sequencing whole-genome sequencing: COVID-19 [DOI] 10.1093/infdis/jiab483 PMC 바로가기 [Article Type] Major Articles and Brief Reports
A low-cost TaqMan minor groove binder probe-based one-step RT-qPCR assay for rapid identification of N501Y variants of SARS-CoV-2SARS-CoV-2의 N501Y 변이체를 신속하게 식별하기 위한 저비용 TaqMan 작은 홈 결합제 프로브 기반 1단계 RT-qPCR 분석Article Published on 2022-01-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 치료기술, [키워드] Accuracy allele frequency analytical sensitivity B.1.1.7 B.1.351 collected COVID-19 detect determine diagnostic Diagnostic accuracy evaluated expand Frequency Genome Genome sequencing gold gold standard health authorities house identify in some Lineage low frequency Mutation N501Y N501Y mutation N501Y variants One-step RT-qPCR positive Prevalence qPCR qPCR assay reduced reference standard respiratory specimen respiratory specimens robust RT-qPCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Surveillance TaqMan time-consuming Transmissibility variant variant of concern variants variants of concern variants of SARS-CoV-2 whole-genome sequencing widespread wildtype [DOI] 10.1016/j.jviromet.2021.114333 PMC 바로가기 [Article Type] Article
Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission전염병 초기 병원 SARS-CoV-2 감염의 역학 및 게놈 통합 분석과 전염에서 미확인 사례의 역할Article Published on 2022-01-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Admissions analysed Asymptomatic asymptomatic patients case ascertainment Cluster Clusters Combined Community consecutive patients coronavirus Coronavirus 2019 COVID-19 creating Diagnosis early stage early stages epidemiological epidemiological data epidemiologically Evidence evidence of Face mask Face masks facilitated Factor Final genome sequence Genomic analysis genomic data Genomics Haplotype healthcare healthcare worker Healthcare workers Healthcare-associated infection hospital implicated incidence increase infection control limit median Molecular epidemiology multisite nosocomial Nosocomial transmission pandemic per day positive PCR test respiratory SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-COV-2 infection sequenced Sequencing severe acute respiratory syndrome Coronavirus Support Transmission transmission cluster transmission clusters vector Viral viral genome sequence whole-genome sequencing with infection [DOI] 10.1016/j.cmi.2021.07.040 PMC 바로가기 [Article Type] Article
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil브라질에서 SARS-CoV-2 감마 변종에 의한 재감염 및 백신 돌파 후 급성 COVID-19 증후군Case Reports Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] B.1.1.33 Brazil Breakthrough infection caused convalescent serum COVID-19 COVID-19 breakthrough infection dose Efficacy Gamma Health Health personnel healthcare worker heterologous vaccine Immune escape Inactivated vaccine Infection Lineage Neutralizing antibodies neutralizing antibody Post-acute COVID-19 syndrome Reinfection SARS-CoV-2 SARS-CoV-2 variants syndrome the SARS-CoV-2 Vaccine variant VoC waning immunity whole-genome sequencing [DOI] 10.1016/j.ijid.2021.10.048 PMC 바로가기 [Article Type] Case Reports