acute COVID-19 – Page 18 – Communicable Diseases Research

Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection

SARS-CoV-2 감염의 급성 후유증에서 폐 기능 장애의 면역 섬유증 드라이버

Clinical Medicine

Published on 2021-07-222022-09-12
Journal: JCI Insight [Category] SARS, 진단,

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

중증 COVID-19 환자의 인간 뇌 면역 반응에 대한 단일 핵 전사체 분석

Research

Published on 2021-07-192022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] absence acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis biological processes Brain brain region brain tissue caused cells cellular activation Choroid plexus Control coronavirus coronavirus disease Coronavirus disease 2019 cortical COVID-19 COVID-19 patients death detect detectable Differential gene expression droplet examined Gene Expression gene regulatory network Host immune response immune response individual cell individual cells individuals Infection Macrophage macrophages Medulla oblongata microglia Mobility Monocytes Neuroinflammation neurological Neuropsychiatric oblongata Patient phagocytosis Prefrontal cortex proportion Region Result RNA sequencing S1 protein SARS-CoV-2 SARS-CoV-2 genome serotypes severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein stromal cells supplementary material time of death trajectory Transcription transcriptional change Transcriptional changes Transcriptome transcriptomes Viral viral spike viral spike protein viral transcript viral transcriptome viral transcripts virus was performed western blot
[DOI] 10.1186/s13073-021-00933-8 PMC 바로가기 [Article Type] Research

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

어린이의 다기관 염증 증후군은 장 점막 장벽의 조눌린 의존성 상실에 의해 유발됩니다

Article

Published on 2021-07-152022-09-11
Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커, 치료기술, 치료제,

[키워드] acute COVID-19 analyzed Antigen antigen detection antigenemia Biomarker biospecimen biospecimens bloodstream breakdown Cardiac complications characterized children children with MIS-C Clinical improvement controls COVID-19 decrease develop diagnosing disease driven by examined Gastrointestinal GI Tract Gut hyperinflammation Hyperinflammatory immune response immune responses increasingly Inflammation Inflammatory Inflammatory marker inflammatory markers intestinal permeability junctions larazotide life-threatening marker mechanistic data MIS-C mucosal mucosal barrier Pathogenesis Patient plasma probe proof proof of concept reverse transcription PCR RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 spike antigen stools subsequent Symptom syndrome target targets the patient tight junctions treated was used were assessed
[DOI] 10.1172/JCI149633 PMC 바로가기 [Article Type] Article

A longitudinal SARS-CoV-2 biorepository for COVID-19 survivors with and without post-acute sequelae

급성 후유증이 있거나없는 코비드 -19 생존자를위한 종 방향 SARS-COV-2 Biorepository

Research Article

Published on 2021-07-132022-09-01
Journal: BMC Infectious Diseases [Category] SARS, 진단,

[키워드] acute COVID-19 acute infection All participants Biobank biobanking Biorepository clinical trial clinically cognitive collected Community coronavirus COVID-19 death demographic data dependent on Diagnosis disease dysfunction enrolled exercise intolerance fatigue Follow-up globe hospital Hospitalization Hospitalized identify Infection initial knowledge Long-hauler longitudinal Loss of Smell loss of taste nasopharyngeal participant PASC pathophysiology Patient PCR phenotype physical positive post infection Post-acute sequelae of COVID-19 (PASC) provide questionnaire recruited reduce Registered reported required Research researcher response responses Result risk Saliva SARS-CoV-2 SARS-COV-2 infection significantly more specimens Spectrum Stool Surveillance survivor Symptom Symptoms symptoms of COVID-19 targeted intervention targeted interventions Taste Treatment vaccination valuable resource Viral viral pathology
[DOI] 10.1186/s12879-021-06359-2 PMC 바로가기 [Article Type] Research Article

Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)

SARS-CoV-2 감염 및 소아의 다기관 염증 증후군(MIS-C)에서 분비성 포스포리파제 A2

Observational Study

Published on 2021-07-132022-09-11
Journal: Experimental Biology and Medicine [Category] 바이오마커, 임상,

[키워드] acute COVID-19 acute illness Admission Asymptomatic Biomarker cellular damage children children with COVID-19 Compound contribute controls convalescent correlated COVID-19 COVID-19 infection COVID-19 severity disease disease pathogenesis distal elevated event Hospitalized IgG antibodies inflammasome activation Inflammatory inflammatory cascade intensive care management mediator Mild MIS-C multisystem inflammatory syndrome in children Patient Patient management pediatric Phospholipase A2 plasma proximal risk SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoVC-2 secretory secretory phospholipase A2 seronegative severe COVID-19 severe disease severity significantly significantly higher syndrome with COVID-19
[DOI] 10.1177/15353702211028560 PMC 바로가기 [Article Type] Observational Study

Characterization of low-density granulocytes in COVID-19

Research Article

Published on 2021-07-062022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Activation acute COVID-19 acute infection acute infections Acute respiratory infection acute viral infections Autoimmune disease Blood Cancer Cell Characteristics characterization characterized circulating neutrophils contribute COVID-19 COVID-19 disease COVID-19 patient demonstrated described detrimental effect disease Disease progression elevated Excessive activation expression flow cytometry granulocyte Granulocytic healthy controls Host immune response humans identify immature immunosuppressive increase in Infection Innate immunity low-density Lung pathology lymphocyte response marker neutrophil Neutrophils pathological mechanism patients Phenotypes populations progression pulmonary complications recruited recruitment Responder significant increase Stage These cells tissue damage
[DOI] 10.1371/journal.ppat.1009721 PMC 바로가기 [Article Type] Research Article

CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer

CD8 + T 세포는 COVID-19 및 혈액암 환자의 생존에 기여합니다

Observational Study

Published on 2021-07-012022-09-12
Journal: Nature Medicine [Category] Fulltext, SARS, 유전자 메커니즘, 임상, 진단, 치료법,

Long-Term Outcomes of Patients with Coronavirus Disease 2019 at One Year after Hospital Discharge

Article

Published on 2021-06-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

Immunology

Published on 2021-06-302022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

SARS-CoV-2 감염 연구를 위한 최고의 항원 및 최고의 면역 바이오마커를 식별하기 위한 탐색적 분석

Research

Published on 2021-06-262022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] acute COVID-19 Analysis Antibody Response Antigen approach AUC best Biomarker Biomarkers Clinical characteristics cohorts COVID-19 demonstrated described develop diagnostics discriminant analysis Disease progression Eotaxin evaluate evaluated Factor FGF foundation G-CSF GM-CSF HCV help highest identify IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-17A IL-1ra IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 immune immune factors immune response Immunity immunogenic immunogenicity induce Infectious disease IP-10 knowledge MCP-1 membrane MIP-1α MIP-1β not affect nucleoprotein ORF3a partial least square Patient PDGF peptide peptide pool peptides RANTES recent recovered patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV2 SARS-CoV2 infection serological spike Spike-based vaccine spike-protein T-cell T-cell Response TNF-α Treatment strategies Tuberculosis Vaccine vaccine candidates vaccine trial VEGF Viral Viral antigen virus Whole-blood
[DOI] 10.1186/s12967-021-02938-8 PMC 바로가기 [Article Type] Research