A lymph node–targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2림프절 표적 양친매성 백신은 SARS-CoV-2에 대한 강력한 세포 및 체액 면역을 유도합니다Research Article Published on 2021-02-052022-09-12 Journal: Science Advances [Category] MERS, 진단, [키워드] ACE2 receptor binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alum amphiphile Antibody Response Antibody responses Antigen antigen-specific T cell candidate vaccine cellular composed consequence convalescent patient coronavirus COVID-19 CpG cytokine Cytokines dose reduction Effective vaccines ENhance evaluated humoral immune response humoral immune responses Humoral immunity IgG3 immune responses immunization induce isotype isotypes lung parenchyma lymph Lymph node lymph nodes mice Modification neutralized preserved produced Protein Protein subunit vaccines Receptor binding Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus spike T cell T cells T helper the SARS-CoV-2 titers translation Vaccine [DOI] 10.1126/sciadv.abe5819 PMC 바로가기 [Article Type] Research Article
SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and ChallengesReview Published on 2021-02-042022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] ACE2 acute respiratory distress Adaptive immune response angiotensin-converting enzyme 2 Antibody titers Asymptomatic CD147 challenge characterized cleavage CLR Coronavirus disease-19 COVID-19 Cytokine storm syndrome displaying domain dysregulation Effect Frame host immune system immune antagonism Immunopathogenesis immunopathology immunotherapies implicated include innate immune system Interaction life-threatening mechanism myeloid non-structural protein Novel coronavirus NRP1 nucleic acid vaccine opportunity Other pathology peptide Potential receptor reduced Research respiratory SARS-CoV-2 SARS-COV-2 infection spike glycoprotein syndrome Therapeutics Therapies therapy TMPRSS2 Treatment Vaccine Vaccines viral spread Viral variants virus Wuhan, China [DOI] 10.3390/idr13010013 PMC 바로가기 [Article Type] Review
Case Report: Adequate T and B Cell Responses in a SARS-CoV-2 Infected Patient After Immune Checkpoint Inhibition사례 보고: 면역 체크포인트 억제 후 SARS-CoV-2 감염 환자의 적절한 T 및 B 세포 반응Case Reports Published on 2021-02-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] Adaptive immune response Adaptive immunity addition Adequate Affect analyzed antibody B-cell response baseline Cancer Cell cellular chemotaxis clinician COVID-19 outbreak COVID-19 pandemic evaluate expression humoral humoral immune response IgM and IgG Immune checkpoint inhibitor Immune checkpoint inhibitors immune response immune system Immunotherapy Infection inhibition kidney neoplasms marker maturation neutralise oncology patient pandemic Patient plasma sample renal response risk factor SARS-CoV-2 subset T cell the SARS-CoV-2 therapy treated Treatment were measured [DOI] 10.3389/fimmu.2021.627186 PMC 바로가기 [Article Type] Case Reports
Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients중증 COVID-19 환자의 SARS-CoV-2에 대한 세포 면역 손상Immunology Published on 2021-02-022022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acute infection acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adaptive immune response Adaptive immunity antibody Antibody Response ARDS CD4 CD8 cellular cellular immunity convalescent individual coronavirus COVID-19 COVID-19 patient develop exhibited expression healthy controls Hospitalization humoral immune responses IFNγ Impaired individual infection rate interferon gamma MOST mounted Neutralization antibody Neutralizing antibodies NK cell pandemic percentage Peripheral blood peripheral blood lymphocyte producing reduced responses SARS-CoV-2 severe COVID-19 patient Severe patient severe patients shown significantly Spread Symptoms syndrome T cell T cells Viral proteins virus [DOI] 10.3389/fimmu.2021.603563 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 convalescent plasma therapy in pediatric patient after hematopoietic stem cell transplantation조혈모세포 이식 후 소아 환자에서 SARS-CoV-2 회복기 혈장 치료Case Reports Published on 2021-02-012022-09-11 Journal: Transfusion and apheresis science : official journ [Category] MERS, SARS, 진단, 치료기술, [키워드] absence Adaptive immune response Atypical Child Clinical symptoms Combination Complete convalescent patient convalescent plasma Convalescent plasma therapy Course COVID-19 curative demonstration Donor dose feature fresh frozen plasma frozen plasma HSCT HSCT recipients hyperimmune Immune status Immunocompromised patients immunodeficiency lack leukemia lung lesions lung tissue myelomonocytic leukemia pathogen pathogen-specific Patient patients pediatric persistence plasma Pneumonia poor prognosis positive SARS-CoV-2 severe COVID-19 stem cell Stem cell transplantation the patient Therapeutic approach throat swab Tocilizumab transfusion treated Treatment Viral Viral pneumonia [DOI] 10.1016/j.transci.2020.102983 PMC 바로가기 [Article Type] Case Reports
Are people with uncontrolled diabetes mellitus at high risk of reinfections with COVID-19?조절되지 않는 당뇨병이 있는 사람들은 COVID-19에 재감염될 위험이 높습니까?Review Published on 2021-02-012022-09-11 Journal: Primary care diabetes [Category] 치료기술, [키워드] Adaptive immune response Chain Reaction contrary COVID-19 diabetes Diabetes Mellitus false-negative rate high risk nucleic acid Nucleic acid detection Patient polymerase chain reaction positive Re-infections Reactivation Reinfection Reinfections. reported RT-PCR Symptomatic patients with COVID-19 [DOI] 10.1016/j.pcd.2020.08.002 PMC 바로가기 [Article Type] Review
The COVID-19 immune landscape is dynamically and reversibly correlated with disease severityClinical Trial Published on 2021-02-012022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] acute COVID-19 Adaptive immune response Adaptive immunity alteration Analysis Clinical improvement Clusters Cohort coronavirus disease correlated Course COVID-19 critically ill patients Cytometry disease disease severity dominant dysregulated immune response family feature foundation hospitalized COVID-19 identify IL-6 pathway immune immune correlate immune response Immunity individual Innate Innate immunity Intervention Leonard longitudinal Mild moderate disease outcome Patient presenting SARS-CoV-2 severe COVID-19 severe disease specimen trajectory were used [DOI] 10.1172/JCI143648 PMC 바로가기 [Article Type] Clinical Trial
Association between markers of immune response at hospital admission and COVID-19 disease severity and mortality: A meta-analysis and meta-regression입원 시 면역 반응 지표와 COVID-19 질병 중증도 및 사망률 간의 연관성: 메타 분석 및 메타 회귀Meta-Analysis Published on 2021-02-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, [키워드] 95% CI 95% confidence interval Adaptive immune response Admission Adult patients age age and sex ALC ANC articles association C-reactive protein C-reactive protein (CRP calculate candidate Coagulation conducted coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 disease severity D-dimer determine disease severity ferritin groups highlight Hospital admission hospitalized COVID-19 patient hospitalized COVID-19 patients hyper inflammation identify IL-6 immune response inclusion criteria interleukin interleukin-6 Intervention intravascular coagulation Laboratory laboratory values LDH lymphocyte Lymphocytes marker material mean difference Meta-analysis meta-regression Mortality neutrophil Neutrophils Pathogenesis pathogenesis of COVID-19 Patient patients random effect sensitivity Sex statistically significant subsequent systematic review the WHO troponin I utility was used [DOI] 10.1002/jmv.26411 PMC 바로가기 [Article Type] Meta-Analysis
T cell and antibody responses to SARS-CoV-2: Experience from a French transplantation and hemodialysis center during the COVID-19 pandemicSARS-CoV-2에 대한 T 세포 및 항체 반응: COVID-19 전염병 동안 프랑스 이식 및 혈액 투석 센터의 경험Article Published on 2021-02-012022-09-11 Journal: American journal of transplantation : official jou [Category] MERS, 바이오마커, 진단, [키워드] Adaptive immune response antibody Antibody Response Antibody responses Antiviral COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient differential diagnosis evaluate experience exposure to form French healthy control Hemodialysis immune response immune responses Immunity immunobiology Immunosuppressed immunosuppressive immunosuppressive therapy Infection infection and infectious agents - viral infectious agent infectious agents involved kidney kidney transplantation / nephrology monitoring: immune Nephrology Patient progression reactivity reduction Research responses risk RT-PCR SARS-CoV-2 serological seronegative severe forms of COVID-19 T cell T cell response T cell responses T cells the disease therapy translational translational research / science. Transplant virus [DOI] 10.1111/ajt.16348 PMC 바로가기 [Article Type] Article
Functional Exhaustion of Type I and II Interferons Production in Severe COVID-19 PatientsMedicine Published on 2021-01-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Adaptive immune response Admission Asymptomatic carried caused Complication complications coronavirus Coronavirus disease 2019 correlated Course COVID-19 COVID-19 patient COVID-19 patients cytokine level cytokine levels Cytokine storm Cytokines described develop disease severity Exhaustion Follow-up form functional healthy subjects highlight hospital Hospitalization identify IFN IFNs IFNα IFNγ IFNγ level IL1β IL6 IL8 Immune cell immune cells immune factor immunological profile immunology in vitro independent Infectious diseases Inflammatory Inflammatory cytokine interferon majority Mild moderate multivariable analysis non-specific observation outcome Patient Personalized medicine plasma Potential biomarker pro-inflammatory cytokine Production Prospective Study reduced remained restored SARS-CoV-2 secretion severe COVID-19 patient significantly increased Spread Th1 the disease the WHO TNFα Treatment Type type I type II IFN type II interferon were measured Wuhan [DOI] 10.3389/fmed.2020.603961 PMC 바로가기 [Article Type] Medicine