A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin’s possible mode of action against SARS-CoV-2이버멕틴의 항바이러스 효과에 대한 실험적 증거의 체계적인 검토 및 SARS-CoV-2에 대한 이버멕틴의 가능한 작용 방식에 대한 실리코 분석Review Published on 2021-04-012022-09-11 Journal: Fundamental & clinical pharmacology [Category] SARS, 신약개발, 치료제, [키워드] 95% confidence interval Antiviral antiviral agent Antiviral effect applicability applied Circoviridae Clinical efficacy Control Coronaviridae Coronaviridae family determine Developing dose economic loss Efficacy Evidence experimental evidence facilitated Flaviviridae Host in silico analysis in vitro In vitro studies in vitro study in vivo infected cell infected cells Infection infections inhibited Ivermectin mammalian mechanism meta-analyses Meta-analysis mice multiple organs nuclear nuclear location signals. nuclear translocation pharmacokinetic Propagation Replication SARS-CoV-2 SARS-CoV-2 genome selective shown standardized mean difference systematic review therapeutic agents toxic Toxicity Trial unmet need viral infection viral infections Viral proteins viral replication virus while [DOI] 10.1111/fcp.12644 PMC 바로가기 [Article Type] Review
Immunological Aspects Related to Viral Infections in Severe Asthma and the Role of OmalizumabReview Published on 2021-03-302022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Allergic asthma Antiviral effect appear aspect Asthma asthma patient Biologicals cellular children Clinical efficacy coronavirus Course effector cells form IgE immune response increased risk Infection Inflammatory initial Innate immunity interferon management monoclonal antibody occur omalizumab progression Protective respiratory infection respiratory viral infections risk factor role SARS-CoV-2 SARS-COV-2 infection Severe asthma susceptible Th2 treated type I viral infection viral respiratory infections viral spread viruses [DOI] 10.3390/biomedicines9040348 PMC 바로가기 [Article Type] Review
Inhibition of HECT E3 ligases as potential therapy for COVID-19COVID-19에 대한 잠재적 치료제로서의 HECT E3 리가제의 억제Article Published on 2021-03-242022-09-11 Journal: Cell Death & Disease [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료제, [키워드] activating Antiviral effect Biomarker Brassicaceae Cell clinical trial clinical trials compounds COVID-19 COVID-19 infected patient E3 ligase Ebola enzymatic activity family members germline identify implicated infected patients Infection inhibit inhibition inhibitor Interaction Medical genomics Mouse models NEDD4 overexpressed pandemic potential therapy Protein responsible RNA virus SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 spike Spike protein target the cell the SARS-CoV-2 therapeutic strategy Treatment variant variants Viral viruses VP40 WWP1 [DOI] 10.1038/s41419-021-03513-1 PMC 바로가기 [Article Type] Article
Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model햄스터 모델에서 SARS-CoV-2에 대한 Favipiravir 항바이러스 효능Article Published on 2021-03-192022-09-10 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] analyses animals anti-SARS-CoV-2 antiviral activity Antiviral effect antiviral efficacy antiviral molecule antiviral molecules clinical trial clinical trials comparable decrease determine dosage dose Drug development Effect Efficacy evaluated Evidence Experimental models of disease Favipiravir fitness Genetic genomes High dose highest dose human clinical trials humans in viral incorporation Infection infectious titer infectious titers initiated lack lung Lungs mechanism of action Mutation pharmacokinetic plasma drug reduction Repurposed drug Repurposed drugs required RNA viruses SARS-CoV-2 tested the disease Therapeutics Tolerance Toxicity Treatment variety Viral viral genome viral genomes viral infectivity [DOI] 10.1038/s41467-021-21992-w PMC 바로가기 [Article Type] Article
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug RepurposingPharmacology Published on 2021-03-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral effect approach Artemisinin benefit candidate clinical trial Concentration coronavirus disease COVID-19 Diagnosis disease modeling dosing regimen dropped drug drug candidate Drug repurposing Effect effective explained Host host response human SARS-CoV-2 Hydroxychloroquine immune response in vitro in vitro experiment in vivo Informed Intervention Ivermectin log lung tissue modeling Pharmacometrics profile reduce Repurposed drug repurposing SARS-CoV-2 selected Treatment viral dynamics viral kinetics Viral load were given [DOI] 10.3389/fphar.2021.625678 PMC 바로가기 [Article Type] Pharmacology
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2Article Published on 2021-03-082022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] ACE2 administration angiotensin-converting enzyme 2 Anti-viral Antiviral Antiviral effect antivirals assist candidate drugs Cell cells cellular receptor drug effective Express generate human cell infection with SARS-CoV-2 inhibitor lentiviral Microbiology progeny reduced Remdesivir replicate Replication respiratory SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication significantly small molecule Spread susceptibility these cell Vaccine development Vero Cell Vero cells Viral RNA Virology virus production worldwide pandemic [DOI] 10.1038/s41598-021-84882-7 PMC 바로가기 [Article Type] Article
Antiviral Activity of the Propylamylatin TM Formula against the Novel Coronavirus SARS-CoV-2 In Vitro Using Direct Injection and Gas Assays in Virus SuspensionsArticle Published on 2021-03-052022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Muscodor albus activity acute respiratory syndrome Antiviral antiviral agent Antiviral effect antiviral therapy approved body temperature Combination component components coronavirus Course COVID-19 Direct effective evaluated experiment faster Formula global public health inactivated inactivation Infectious virus injection investigated majority Mild Moderate COVID-19 novel novel coronavirus disease occurred Plaque assay Potential treatment propionic acid provided quantified reduction in Remdesivir SARS-CoV-2 severe COVID-19 Suspension synergy temperature therapeutic Treatment undetectable VERO E6 cells viral inactivation virus Volatile organic compounds Volume [DOI] 10.3390/v13030415 PMC 바로가기 [Article Type] Article
Quantitative evaluation of SARS-CoV-2 inactivation using a deep ultraviolet light-emitting diodeArticle Published on 2021-03-032022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome analyzed Antiviral effect Biophotonics center wavelength conditions coronavirus coronavirus disease COVID-19 Critical culture media dose Effect Effects inactivation Inorganic LEDs knowledge microorganism mitigate performed Quantitative required SARS-CoV-2 Spread ultraviolet Variation viral infection viruses [DOI] 10.1038/s41598-021-84592-0 PMC 바로가기 [Article Type] Article
Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effectResearch Article Published on 2021-03-012022-10-30 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID-19, [키워드] Alter Antiviral effect calu-3 cells Cell Concentration demonstrated distribution Elevation epithelial exposure Extracellular H2O2 hepatocyte HIEC-6 host protease TMPRSS2 Human IL-6 IL-8 inhibitor intestinal intestinal epithelial cell membrane-bound new SARS-CoV-2 not affect occludin PHH Prevent redox status Replication serine protease serine protease inhibitor Spread treated Treatment trypsin-like serine protease inhibitors viability [DOI] 10.1080/14756366.2021.1886093 PMC 바로가기 [Article Type] Research Article
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice엔도솜 산성화 억제제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스에서 바이러스성 폐렴을 완화합니다Research Published on 2021-02-272022-09-10 Journal: Virology Journal [Category] MERS, 치료기술, 치료제, [키워드] 293T 293T-ACE2 cells acidic pH alveolar Analysis Antiviral effect antiviral effects bafilomycin Bafilomycin A1 caused CCK-8 CCK-8 assay Cell Chloroquine Clinical use coronavirus disease Coronavirus disease 2019 COVID-19 detect distribution Drug development Endosomal acidification endosome Endosomes eosin evaluate global pandemic hACE2 hematoxylin Huh-7 In situ hybridization Infection infiltration Inflammatory inhibitor inhibitors investigated lung tissue lung tissues pathological change peribronchiolar perivascular tissues Pneumonia proliferation provide reduced Replication Research Result RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly staining Structure suppress the SARS-CoV-2 transgenic mice used to evaluate Vero E6 Vero E6 cell VERO E6 cells viability Viral Viral pneumonia viral replication was used [DOI] 10.1186/s12985-021-01515-1 PMC 바로가기 [Article Type] Research