cascade – Page 18 – Communicable Diseases Research

Piece of Cake: Coping with COVID-19

Article

Published on 2020-12-112022-10-31
Journal: Nutrients [Category] COVID-19, MERS, SARS,

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Immunology

Published on 2020-12-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자,

[키워드] acute respiratory distress amplifying approach cascade cell interaction cellular chemokine chemokines clinical manifestation cough COVID-19 COVID-19 patients Critical cytokine Cytokine storm Cytokines death dysregulated Effect elevated expected febrile illness Hypothesis infected with SARS-CoV-2 Inflammatory response Mild Mild symptom much higher multiple organ failure NF-kappaB NF-κB NSAID pathway Patient Perspective Potential Prevent pro-inflammatory pro-inflammatory cytokine proteasome inhibitor provide SARS-CoV-2 (2019-nCoV) severity Severity of disease Stage syndrome synergistic target Therapeutic approach therapeutic potential triggering
[DOI] 10.3389/fimmu.2020.598444 PMC 바로가기 [Article Type] Immunology

Optimizing COVID-19 surveillance in long-term care facilities: a modelling study

장기 요양 시설에서 COVID-19 감시 최적화: 모델링 연구

Research Article

Published on 2020-12-082022-09-10
Journal: BMC Medicine [Category] MERS, SARS, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis Asymptomatic baseline Care cascade cascades Chain Reaction clinical symptom Computational modelling Contact Contact network coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms cumulative detect diagnostic diagnostic sensitivity distribution effective Efficacy epidemiological epidemiological surveillance evaluated expressing facilitate group test IMPROVE Increasing indication inefficient Infection infections Infectious disease surveillance information inter-individual Interaction Intervention limitations Long-term care Mathematical modelling Nasopharyngeal swab nasopharyngeal swabs nosocomial Nosocomial transmission outbreak Outbreaks Patient polymerase chain polymerase chain reaction pooling pre-symptomatic Probability proportion protocol public health random Randomly resource resources respiratory Result reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR tests SARS-CoV-2 SARS-COV-2 infection selected sensitivity severe acute respiratory syndrome Coronavirus silent supplementary material Surveillance Swab Symptom symptom onset Symptoms Testing transcriptase Transmission Transmission dynamics
[DOI] 10.1186/s12916-020-01866-6 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article

The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19

COVID-19와의 전쟁에서 약물 시험을 설계하기 위해 바이러스 직접 세포병증 가설의 적용

Article

Published on 2020-12-012022-09-11
Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] SARS, 임상, 치료제,

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다

Article

Published on 2020-11-302022-09-11
Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단,

[키워드] abrogate ACE2 ACE2‐Fc activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin II antibody block cascade caused cells cellular receptor Characteristics circumvent coronavirus COVID‐19 COVID‐19 cytokine D614G variant D614G variants decoy antibody degranulation demonstrated develop domain effective enzyme fusion protein H1975 humanized immunology impairment Infection Interaction lung cell lung cells lung organoids Microbiology, Virology & Host Pathogen Interaction NK cell not affected pandemic peptidase preservation Prevent Pseudotyped virus reduce respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus shown Spike protein Strains therapeutic Treatment Viral viral entry viral spike protein virus infection virus replication virus variants
[DOI] 10.15252/emmm.202012828 PMC 바로가기 [Article Type] Article

Treatment of COVID‐19 patients with the anti‐CD6 antibody itolizumab

Original Article

Published on 2020-11-252022-10-31
Journal: Clinical & Translational Immunology [Category] COVID-19,

[키워드] administration adverse event age antibody Autoimmune disease Biomarker cascade CD6 Clinical data Combination Comorbidities Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Cytokine release syndrome death Deterioration discharged events expressed FiO2 glycoprotein hospitals Hyperinflammatory hyperinflammatory state ICU IL‐6 individual itolizumab lethality rate Lower Lung function moderate monoclonal antibody morbidity and mortality Mortality Most patient multiple cytokine National neurological manifestation NLR objective pathway Patient patients Prevent prevented proportion protocol reduce reduced Result SARS‐CoV‐2 SARS‐COV2 Secondary objective severe cases Severe patient severe patients significantly subject T lymphocyte T‐cell activation Th1/Th17 therapy time treated Treatment Ventilation
[DOI] 10.1002/cti2.1218 PMC 바로가기 [Article Type] Original Article

Host genetic susceptibility to viral infections: the role of type I interferon induction

Reviews

Published on 2020-11-202022-10-05
Journal: Genes and Immunity [Category] 유전자 메커니즘,

Unique fibrinogen-binding motifs in the nucleocapsid phosphoprotein of SARS CoV-2: Potential implications in host-pathogen interactions

SARS CoV-2의 뉴클레오캡시드 인단백질의 독특한 피브리노겐 결합 모티프: 숙주-병원체 상호작용의 잠재적 의미

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] SARS, 치료법,

[키워드] Asymptomatic binding Blood blood clot Blood clots blood clotting cascade clinical manifestation clinical manifestations clinical observation Coagulase Coagulation condition contagious Corona virus coronavirus COVID-19 Critical Critical illness death disease Disseminated intravascular coagulation Economy etiological agent evade fibrinogen function functions global health Health help homologous Host Host immune response host-pathogen interaction Hypothesis immune evasion implication in vitro incidence increase in increased risk induce infected patient infected patients infecting Infection information Interaction intravascular coagulation mechanism Mild molecular mechanisms morbidity and mortality motif Motif. N-protein novel Novel coronavirus nucleocapsid pandemic Potential Protein Proteins prothrombin regulate SARS CoV SARS CoV-2 SARS CoV-2 infection Stage Staphylococcus aureus tested therapeutic strategy turn unique virus von Willebrand factor
[DOI] 10.1016/j.mehy.2020.110030 PMC 바로가기 [Article Type] Article

Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19

Telmisartan, COVID-19에 대한 잠정적 지오텐신 수용체 차단제 치료제

Article

Published on 2020-11-012022-09-11
Journal: Drug development research [Category] SARS, 임상,

[키워드] ACE2 airway alveolar cell alveolar cells Angiotensin 1-7 Angiotensin II angiotensin receptor blocker Apoptosis ARDS binds cascade China clinical trial complex Complication Concentration coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines decrease Degradation disease Election endocytosis Epidemic inflammatory process losartan lung membrane protein New coronavirus Open-label pharmacokinetic physiological pro-inflammatory produced proinflammatory cytokines promote Randomized reducing S protein SARS Coronavirus SARS-CoV-2 SARS-CoV-2 virus telmisartan telmisartan. the S protein therapeutic tissue treating COVID-19 patient turn type 2 alveolar cells virus Wuhan
[DOI] 10.1002/ddr.21679 PMC 바로가기 [Article Type] Article