Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany독일 바이에른의 COVID-19 환자의 증상 발병과 관련하여 호흡기 표본에서 SARS-CoV-2의 검출 및 바이러스 RNA 방출Article Published on 2021-06-232022-09-11 Journal: Epidemiology and Infection [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Chain Reaction clearance comparable coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 patient Ct-value Ct-values cycle threshold detection diagnostic diagnostic sensitivity estimate Germany individual Kaplan-Meier plot Kaplan-Meier plots lowest Patient patients presymptomatic transmission Probability proportion remained reported respiratory specimen reverse transcriptase reverse transcriptase-polymerase chain reaction Ribonucleic acid RNA RT-PCR sampling SARS-CoV-2 SARS-CoV-2 detection scatterplot sensitivity Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 specimen subset symptom onset symptomatic tested the timing Viral load viral ribonucleic acid Viral RNA Viral RNA shedding was used were used [DOI] 10.1017/S0950268821001345 PMC 바로가기 [Article Type] Article
Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s DiseaseNeuroscience Published on 2021-06-152022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] acute respiratory syndrome addition Brain cells Central nervous system change clearance CNS contribute coronavirus Coronavirus disease 2019 COVID-19 death delirium disease disorders Genetic globe highlight homeostatic Hyposmia immunopathology in viral include individual Infection infections Invasion lesson mechanism Meningitis MERS-CoV microglia microglial Middle East neurodegeneration Neurodegenerative diseases Neuroinvasive neurological Neurological symptom neurons neuropsychiatric disorders neurotropic outbreak pandemic Parkinson’s disease Parkinson’s disease pathogenic pathophysiology plasticity provide re-infected Reinfection Relevance respiratory syndrome coronavirus response responsible rising RNA RNA virus SARS-CoV-2 SARS-COV-2 infection stroke vasculature viral clearance viral infection viral RNA neurotropism [DOI] 10.3389/fncel.2021.670298 PMC 바로가기 [Article Type] Neuroscience
Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonistArticle Published on 2021-06-112022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Administered agonist benfluorex cells clearance Control CYP26A1 downstream downstream genes drug expression fat highest dose increased expression Lipid signalling liver mice NAFLD nontoxic occurred pathway reduction reversed secretion SPNS2 steatosis Target validation therapeutic [DOI] 10.1038/s41419-021-03862-x PMC 바로가기 [Article Type] Article
Efficacy and Safety of Hydroxychloroquine for Hospitalized COVID-19 Patients: A Systematic Review and Meta-AnalysisReview Published on 2021-06-052022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI adverse events all-cause mortality analyses caused clearance clinical recovery Controlled trial controls COVID-19 discharge dose Efficacy and safety Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine ICU admission increased mortality inverse mechanical ventilation Meta-analysis Mortality non-invasive ventilation not affect outcome oxygen support performed Pneumonia radiological progression random effect ranged RCT RCTs review SAE Safety searched secondary Secondary outcomes Serious Adverse Event severe adverse events significantly higher subgroup analysis Treatment worsening [DOI] 10.3390/jcm10112503 PMC 바로가기 [Article Type] Review
Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia A retrospective analysis on pharmacokinetics and pharmacokinetic target attainmentObservational Study Published on 2021-06-042022-10-04 Journal: Medicine [Category] SARS, 임상, [키워드] ß-lactams Affect Analysis analyzed antibiotic Antibiotic therapy breakpoint change clearance community-acquired pneumonia Concentration continuous infusion coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient Critical illness Critically ill patient critically ill patients daily dose defined demonstrated determine exceeded less median Patient patients patients with pneumonia pharmacokinetic PK/PD Pneumonia resources Retrospective analysis risk factor Safe serum significant difference significantly single-center tested therapeutic therapeutic drug Therapeutic Drug Monitoring Treatment [DOI] 10.1097/MD.0000000000026253 PMC 바로가기 [Article Type] Observational Study
Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other CoronavirusesSARS-CoV-2 감염에서 자가포식, 전개된 단백질 반응 및 뉴로필린-1 상호작용: 다른 코로나바이러스로부터 배울 수 있는 것Review Published on 2021-06-012022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, 치료제, [키워드] ACE2 activate acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Apoptosis arms race autophagy benefit binding Can caused cell surface receptors cellular cellular response Cellular responses cellular stress response cellular stress responses clearance Coronavirus infection COVID-19 COVID-19 complication COVID-19 complications COVID-19 infection COVID-19 mortality COVID-19 pandemic cytokine Cytokine storm DCs dendritic cell dendritic cells effort endoplasmic reticulum stress ENhance enzyme evolutionary arms race gastrointestinal complication gastrointestinal complications generate health emergency help host cell host cells humans identify immune system increase induce infected cells Infection Innate immunity involved mechanism modulation Mortality mTOR neuropilin Neuropilin-1 NRP1 Other pathogen Pathogens pathway Pathways potential therapeutic target potential therapeutic targets reduce regulated Regulation required respiratory response SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection signaling pathway specific treatment stress responses susceptibility tissue homeostasis Treatment unfolded protein response UPR Viral viral infection Viral particles virus virus infection viruses [DOI] 10.3390/ijms22115992 PMC 바로가기 [Article Type] Review
Animal models for SARS-Cov2/Covid19 research-A commentarySARS-Cov2/Covid19 연구용 동물 모델-A 논평Review Published on 2021-06-012022-09-11 Journal: Biochemical pharmacology [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 addition animal animal model BALB/c cellular receptor clearance clinical feature Clinical features Co-infection Combination COVID 19 COVID-19 COVID-19 disease COVID-19 pathogenesis Critical disease drugs Effect FCgRT Gene Expression hematologic homolog humanized Immunity IMPROVE Infection Initiation codon knock-out Lung pathology mechanism modeling mouse model Multigene humanized mouse models offer pathology platform Precision preparation primary antibody protease random receptor receptors Research researcher Responder responders resulting SAR-CoV-2 SARS CoV SARS CoV-2 SARS CoV-2 infection selected strain suggested targets Th1 Th2 therapeutic efficacy TMPRSS2 TMRPSS2 transgene transgenic model unnatural Vaccine Variability [DOI] 10.1016/j.bcp.2021.114543 PMC 바로가기 [Article Type] Review
Clinical applications of mesenchymal stromal cell-based therapies for pulmonary diseases: An Update and Concise ReviewReview Published on 2021-06-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, [키워드] Bacterial bronchopulmonary dysplasia Cell-based therapy chronic lung disease chronic obstructive clearance clinical clinical study clinical trial community-acquired pneumonia conditions Contact COPD curative treatment death disease disorder Effect effective Efficacy ILD immunomodulatory activities Interstitial lung disease lung cancer Lung diseases mechanisms Meta-analysis morbidity MSC MSCs offer paracrine pulmonary disease pulmonary diseases pulmonary fibrosis reported Research review stromal cell syndrome systematic review Therapeutic approach therapeutic option therapeutic potential therapy tissue regeneration Treatment [DOI] 10.7150/ijms.59218 PMC 바로가기 [Article Type] Review
Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus InfectionsReview Published on 2021-05-312022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Adaptive immune response advance antibodies clearance complement contribute Efficacy emerging viruses ENhance Factor Fc effector functions Fc receptor Gamma identification in vitro in vivo include infected cells infections Interaction Isolation mAb modulation monoclonal antibody Mouse models neutralization protection Requirement SARS-CoV-2 pandemic screened selected Treatment viral neutralization virions virus while [DOI] 10.3390/v13061037 PMC 바로가기 [Article Type] Review