Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
나노바디 칵테일은 SARS-CoV-2 D614G N501Y 변종을 강력하게 중화하고 마우스를 보호합니다.
423
[키워드] ACE2
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
administration
angiotensin
angiotensin-converting enzyme 2
antibody
antigenic site
antiviral therapeutics
blocked
Concentration
concentrations
coronavirus
COVID-19
Cryo-electron microscopy
cryo-EM
Crystallography
D614G
D614G variant
domain
enzyme
epitope
epitope mapping
fusion
human population
human populations
Immunity
immunized
mice
N501Y
nanobodies
nanobody
neutralize
neutralized
Neutralizing
Neutralizing antibodies
Prophylactic
PROTECT
RBD
RBD variant
RBD variants
receptor
Receptor-binding domain
receptor-binding domains
reduced viral load
respiratory
SARS-CoV-2
SARS-CoV-2 D614G
SARS-CoV-2 virus
severe acute respiratory syndrome Coronavirus
Significance
spike trimer
Therapeutics
Treatment
treatment of COVID-19
variant
Viral
viral loads
wild-type SARS-CoV-2
X-ray crystallography
[DOI] 10.1073/pnas.2101918118 PMC 바로가기 [Article Type] 423
[DOI] 10.1073/pnas.2101918118 PMC 바로가기 [Article Type] 423