Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico ApproachResearch Article Published on 2021-10-262022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] in silico prediction Alpha Amino acid amino acid change amino acid variation antigenicity association B.1.1.7 B.1.351 B.1.617 binding affinity binding domain collected Complete conformational change COVID-19 D614G dispersion E484K evade Evolution of SARS-CoV-2 genomic GISAID glycoprotein greater hACE2 Host hypothetical immune immunoinformatics immunological in silico information initiative lineages Mutation mutations N439K N501Y P.1 pandemic Positive selection positive-sense single-stranded RNA predicted prediction Protein residue S protein S protein variant SARS-CoV-2 SARS-CoV-2 variant sequence spike Surveillance the Spike Transmission Vaccines variants variants of concern Variation virus VOCs [DOI] 10.1128/mBio.02687-21 PMC 바로가기 [Article Type] Research Article
Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated MicrothrombosisResearch Article Published on 2021-10-232022-10-28 Journal: Advanced Science [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adverse outcome age antibodies binding Blood Blood coagulation boost can be used coated with coronavirus coronavirus disease COVID‐19 patients D614G detection Endothelial cell enzyme examined genetic heterogeneity hACE2 Host immune response in viral increasingly Infection Inflammation inhibition Microfluidic chip Microthrombosis outcomes Patient patients platform presence of comorbidity protective mechanism Protein Rapid reduce reported Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 sequence spike tested therapy thought thrombosis thrombotic complication thrombotic event Thrombotic events vaccination Vaccine variant vector Whole blood [DOI] 10.1002/advs.202103266 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 20212021 년 2 월 코네티컷의 개에있는 심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2)Brief Report Published on 2021-10-232022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conducted Connecticut coronavirus coronavirus 2 COVID-19 D614G diagnostic died dog dominant ENhance Epidemiology Genetic Genome sequencing HCoV Human identify In situ hybridization Laboratory Lineage multiple organ multiple organs Mutation negative Nsp12 P323L Phylogenetic analysis positive postmortem examination public health real time-PCR respiratory reverse transcription RNA RNAscope RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus submitted substitutions sudden death The United States United States Viral Viral RNA virus Winter zoonotic [DOI] 10.3390/v13112141 PMC 바로가기 [Article Type] Brief Report
Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaquesResearch Article Published on 2021-10-222022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] absence animal B.1 B.1.1.7 B.1.351 bronchoalveolar can be used caused changes in chemokine circulation clinical disease confounding factors cytokine D614G description Efficacy favor immune evasion inoculated inoculation less lung lung lesions Medical countermeasures nasal samples pathogenicity phenotypical Replication respiratory tract rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 variant severe disease Transmissibility up-regulated variants of concern virus titers VoC [DOI] 10.1126/sciadv.abj3627 PMC 바로가기 [Article Type] Research Article
Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and TransmissionMicrobiology Published on 2021-10-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome ADAR analyzed APOBEC association Asymptomatic Beta clinical Clinical outcome Complete coronavirus coronavirus 2 coronavirus disease correlated COVID-19 Critical D614G enzyme Epidemic expression Frame Frequency Gamma GISAID database hotspot mechanism Mild mild case Mutation mutation hotspots mutations occur occurred ORF1ab outcome pandemic predict Prevalence Q57H RdRP respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 sequence severe cases severe disease shown single-nucleotide SNV strain Strains symptomatic the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding variant [DOI] 10.3389/fmicb.2021.753823 PMC 바로가기 [Article Type] Microbiology
In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four MutantsArticle Published on 2021-10-172022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 ACE2 binding inhibitor ACE2 receptor applicability aqueous B.1.617.2 Compound COVID-19 D614G dandelion Delta E484K Effect Efficacy Extract form human ACE2 receptor Immune escape in vitro result K417N kidney leaf lentivirus lung cell lung cells multiple mutation mutant N501Y new SARS-CoV-2 Non-invasive Particle prevented pro-inflammatory Prophylaxis Protein–protein interaction pseudotyped reported Research S1 spike mutation Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 prevention SARS-CoV-2 spike secretion sequence shown spike surface Taraxacum officinale the spike protein variant wild type Wuhan [DOI] 10.3390/ph14101055 PMC 바로가기 [Article Type] Article
dsmCRISPR: Dual synthetic mismatches CRISPR/Cas12a-based detection of SARS-CoV-2 D614G mutationdsmCRISPR: 이중 합성 불일치 CRISPR/Cas12a 기반 SARS-CoV-2 D614G 돌연변이 검출Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Amino acid amplify annealing temperature base caused complementary coronavirus COVID-19 COVID-19 disease COVID-19 pandemic CRISPR Critical D614G D614G mutation detect dominant dsmCRISPR. Efficacy evade Fluorescence gene encoding globe Human immune system immunization IMPROVE mismatch Mutation nucleic acid pandemic Point mutation position primer RNA SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus Spike protein spreading the SARS-CoV-2 the spike protein variant virus was increased was used [DOI] 10.1016/j.virusres.2021.198530 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Evolution among Oncological Population: In-Depth Virological Analysis of a Clinical CohortArticle Published on 2021-10-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] amino acid change analyzed bioinformatics biological sample clinical Cohort compartment D614G deep sequencing detect Evolution High-throughput sequencing higher risk hosts Minority variants Mutation mutations nasopharyngeal swab sample nucleotide position oncological patients ORF1ab gene Patient patient cohort patients Replication respiratory tracts SARS-CoV-2 selected Sequencing turn variant variants Viral mutations viral strain Viral variants was performed [DOI] 10.3390/microorganisms9102145 PMC 바로가기 [Article Type] Article
High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic and Epidemiologic Tool for SARS-CoV-2 and Other Viruses고 처리량 차세대 시퀀싱 호흡기 바이러스 패널 : SARS-COV-2 및 기타 바이러스를위한 진단 및 역학 도구Communication Published on 2021-10-142022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 치료기술, [키워드] Accuracy clade co-circulating virus contributing to COVID-19 COVID-19 pandemic Critical D614G Diagnosis disease Epidemiology evaluated Evolution Factor Georgia groups identify include independent information isolate isolates Lineage mitigate Mutation neglect Next-generation sequencing NGS ORF1 ORF1ab ORF3a ORF8 Other outbreak pandemic Pathogens Performance metrics predict prevalent Prevent public health Q57H required respiratory respiratory viral respiratory viral panel respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 variant Spike protein threat Transmission USA utility variant variants Viral viral pathogens Viral transmission virus virus transmission viruses [DOI] 10.3390/v13102063 PMC 바로가기 [Article Type] Communication
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity바이러스 감염에 대한 SARS-CoV-2 변이체 N501Y.V1 및 N501Y.V2 스파이크의 특성화Cellular and Infection Microbiology Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] antiviral immunity B.1.1.7 B.1.351 characterization contribute coronavirus disease Coronavirus disease 2019 COVID-19 D614G demonstrated drug Efficiency endocytosis evade Host Infection Infectivity inhibitor inhibitors Mutation N501Y N501Y.V1 N501Y.V2 pathogen protease Protein pseudotype pseudovirus raised reported S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variants sensitivity South Africa spike Spread stability stomatitis thermal stability United Kingdom variant variants vesicular stomatitis vesicular stomatitis virus virion virus wildtype [DOI] 10.3389/fcimb.2021.720357 PMC 바로가기 [Article Type] Cellular and Infection Microbiology