Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2: A Combined in silico and in vitro StudyArticle Published on 2022-02-012023-07-06 Journal: Molecular informatics [Category] COVID19(2023년), [키워드] COVID19 docking Drug repurposing main protease MD simulations SARS-CoV-2 Spike/ACE-2 Virtual screening [DOI] 10.1002/minf.202100062 PMC 바로가기
Identification of potentially anti-COVID-19 active drugs using the connectivity MAP연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인Research Article Published on 2022-01-272022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus [DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article
A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanismResearch article Published on 2022-01-262022-10-05 Journal: Patterns [Category] 신약개발, [키워드] Alzheimer disease approach candidate Candidates clinical study Compound computational modeling Data integration demonstrated drug Drug repurposing Genes HDAC6 identify in vitro screening Knowledge graph mechanism pathophysiological mechanism pathophysiology Phosphorylation resulting screened target tau phosphorylation upstream variety [DOI] 10.1016/j.patter.2021.100433 [Article Type] Research article
Looking at COVID-19 from a Systems Biology Perspective시스템 생물학 관점에서 코로나19를 바라보다Review Published on 2022-01-222022-09-11 Journal: Biomolecules [Category] 신약개발, [키워드] analyzed approach artificial intelligence Biology characteristic Classifier clinical outcomes COVID-19 dataset datasets disease disease classifiers Drug repurposing form forms generate health emergency Host Interaction interactomics multifactorial network medicine outbreak pandemic pathway Perspective proteomics reduced response to therapy SARS-CoV-2 pandemic Scientific community severity Spread suggested System Systems biology target the SARS-CoV-2 therapy Virus-host interactions [DOI] 10.3390/biom12020188 PMC 바로가기 [Article Type] Review
Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients화학 물질 및 약초 성분의 네트워크 분석 및 스크리닝을 통한 COVID-19의 잠재적 치료 목표 및 메커니즘의 확인Article Published on 2022-01-172022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis applied approved drugs candidate Candidates COVID-19 COVID-19 disease COVID-19 pandemic data-driven disease disease module drug Drug repurposing Drug screening drug target enrichment analysis feasibility herbal ingredients hub protein identification ingredient Invasion mechanism Metrics molecular docking network analysis network pharmacology Network proximity Outbreaks pandemic potential therapeutic target PPI predict target the disease therapeutic effect virus [DOI] 10.1093/bib/bbab373 PMC 바로가기 [Article Type] Article
A new glimpse on the active site of SARS-CoV-2 3CLpro, coupled with drug repurposing studyOriginal Article Published on 2022-01-102023-07-01 Journal: Molecular diversity [Category] COVID19(2023년), SARS, [키워드] 3CLpro COVID-19 Drug repurposing paritaprevir QSAR Radial distribution function [DOI] 10.1007/s11030-021-10355-8 PMC 바로가기 [Article Type] Original Article
Antidepressant Sertraline Is a Broad-Spectrum Inhibitor of Enteroviruses Targeting Viral Entry through Neutralization of Endolysosomal AcidificationArticle Published on 2022-01-082023-08-29 Journal: Viruses [Category] E형 간염, [키워드] antidepressant sertraline broad-spectrum antiviral Drug repurposing enterovirus host-cell targets viral entry [DOI] 10.3390/v14010109 PMC 바로가기 [Article Type] Article
Network analytics for drug repurposing in COVID-19COVID-19의 약물 용도를위한 네트워크 분석Problem Solving Protocol Published on 2022-01-072022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, 치료제, [키워드] analyzed approach bioinformatics clinical study Combination combinations COVID-19 drug Drug repurposing drug target Factor Factors Host host factors identify molecular network network biology network controllability offer other diseases PPI Protein Protein–protein interaction SARS-COV-2 infection target the disease therapy [DOI] 10.1093/bib/bbab490 PMC 바로가기 [Article Type] Problem Solving Protocol
Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatmentArticle Published on 2022-01-012022-11-15 Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome antivirals approach approved Baricitinib clinical trials Compound conditions coronavirus coronavirus disease COVID-19 death Dexamethasone drug drug combination Drug repurposing effective effective drug Epidemic Evidence food growth indication International mechanism of action molnupiravir multiorgan disease patients Progress progression public health emergency Remdesivir Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient selected suppress tested Tocilizumab Treatment turn viral outbreak WHO World Health Organization [DOI] 10.1177/17534666221132736 PMC 바로가기
Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome숙주 전사체의 통합 생물정보학 분석을 사용하여 COVID-19 병인 및 치료법에 대한 잠재적인 새로운 통찰력 식별Article Published on 2022-01-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis analyzed axon guidance Bioinformatics analysis clinical trials combating COVID-19 COVID-19 pathogenesis database DEGs differentially expressed gene Differentially expressed genes DNA drug drug candidate drug candidates Drug repurposing drug target dysfunction enrichment enrichment analysis entrectinib exacerbate Exemestane expressed fibrosis Functional module analysis gene expression profile help hidden host transcriptome Host transcriptome and drug repurposing hub genes hypercytokinemia identify identifying IMPROVE induce Interaction kinase kinases Lung fibrosis mechanism molecular mechanism molecular mechanisms omeprazole overexpression overlapping Pathogenesis pathogenesis of COVID-19 pathogenic pathway Pathway analysis Pathways performed PPI predicted protein-protein interaction Protein-protein interaction network selected Sema7A System Systems biology target targets TINF2 transcription factor transcription factors transcriptional profile transcriptional profiles Transcriptome Treatment was performed was used [DOI] 10.1016/j.ijbiomac.2021.11.124 PMC 바로가기 [Article Type] Article