Extracellular – Page 18 – Communicable Diseases Research

Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019

항바이러스 효과 예측을 위해 하이드록시클로로퀸의 시험관 내 항바이러스 활성과 생체 내 농도 연결: 코로나바이러스 질병 2019 환자 치료의 중요한 단계

Article

Published on 2020-12-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제,

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

A549 세포에 대한 해양 2차 대사산물 폴리포스페이트의 형태유전학적(뮤신 발현) 및 잠재적인 항-코로나 바이러스 활성

Article

Published on 2020-12-142022-09-10
Journal: Marine Drugs [Category] MERS, SARS, 바이오마커,

[키워드] A549 A549 cell ACE2 receptor activity addition adenylate kinase ADK alkaline phosphatase ALP alveolar antiviral response ATP attachment Bacteria binding block Blood Blood platelets Bronchial epithelium Cell cell growth cells cellular collagen coronavirus coronavirus SARS-CoV-2 epithelial Express expression Extracellular extracellular ATP growth human alveolar cells hydrogel immunostaining in vitro in vivo Inhaled inhibiting Innate immunity involved metabolic energy MUC1 MUC5AC mucin mucins nasopharynx nontoxic pathogen Pathogens phosphatase physiological Platelets Polymer polyp polyphosphate Potential protective effect Proteins RBD Receptor binding domain reduction in released SARS-CoV-2 spike protein secondary secreted significantly increased stimulated strength the cells These cells Viral viral RBD virus well
[DOI] 10.3390/md18120639 PMC 바로가기 [Article Type] Article

Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19

COVID-19 성인 입원 환자의 생존자와 비생존자의 실험실 마커의 시간적 변화

Comparative Study

Published on 2020-12-112022-08-31
Journal: BMC Infectious Diseases [Category] MERS, SARS, 바이오마커,

[키워드] acidity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin albumin-globulin ratio alkaline phosphatase Analysis aspartate Aspartate aminotransferase base excess Bicarbonate Blood blood cell blood cell count C-reactive protein calcium carbon dioxide caused Cell changes changes in cholesterol cholinesterase Clinical characteristics clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase cystatin C D-dimer death Degradation Degradation product determine diagnosed with COVID-19 distribution eosinophil Eosinophil count estimated glomerular filtration rate Extracellular Extracellular fluid FIBRIN filtration rate fluorescent fraction glomerular filtration rate Glucose Haemoglobin high risk High-density lipoprotein High-density lipoprotein cholesterol Hospitalized hypersensitive C-reactive protein immature Inpatient International international normalized ratio Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lipoprotein cholesterol lymphocyte Lymphocyte count Magnesium marker mean platelet volume Mild monocyte Myoglobin neutrophil neutrophil count nitrogen non-survivor Non-survivors normalized occurred ogen outbreak Patient patient condition phosphatase phosphorus plasma plasma urea Platelet Platelet count platelet distribution width prealbumin procalcitonin progression Protein prothrombin Prothrombin time red blood cell red blood cell count Result SARS-CoV − 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significant difference significant differences significantly significantly increased sodium supplementary material survivor Temporal Temporal changes test results total calcium Total cholesterol total protein Treatment Triglyceride urea urea nitrogen uric acid variable variables Volume White blood cell white blood cell count width with COVID-19 Wuhan
[DOI] 10.1186/s12879-020-05678-0 PMC 바로가기 [Article Type] Comparative Study

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

Public Health

Published on 2020-12-102022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] ACE-2 Activation acute respiratory syndrome administration angiotensin-converting enzyme 2 anti-inflammatory property Arthritis bee bee venom bee venom in clinical trials candidate cellular characterized China complementary complementary medicine and alternative medicine coronavirus COVID-19 and complementary medicine Cytokine storm syndrome disease Efficacy Epidemiological study expression Extracellular H1N1 HIV humoral IFN-γ IgE IgG antibodies IL-6 IL-8 immune system Immunity immunize Inflammation interact interferon-γ interleukin-6 kinase Local management Medicine melittin Neurological diseases NF-κB non-enveloped viruses nuclear offer Pathways pharmokinetics of bee poison Phospholipase A2 Potential proinflammatory cytokines Protein receptor SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-CoV-2 infections suppress therapy TNF-α tumor necrosis factor-α virus
[DOI] 10.3389/fpubh.2020.594458 PMC 바로가기 [Article Type] Public Health

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

SARS-CoV-2를 무력화하는 강력하고 탄력적인 hACE2 미끼의 새로운 설계

Report

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect angiotensin best binding Cell cells coronavirus cryo-EM de novo decoy decrease develop effort Extracellular hACE2 hamster hamsters host protein host receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo infect Interaction intranasal intrinsically Microscopy mutant nanomolar affinity neutralize neutralized Neutralizing optimization pathogen Pathogens prophylactic dose Protein Protein design RBD RBDs Receptor-binding domain replicate respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus specificity Spike protein subsequent the cell the receptor-binding domain the spike protein therapeutic therapy unlikely Viral virus
[DOI] 10.1126/science.abe0075 PMC 바로가기 [Article Type] Report

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

CD147-스파이크 단백질은 SARS-CoV-2가 숙주 세포에 감염되는 새로운 경로입니다

Article

Published on 2020-12-042022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] ACE2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-CD147 antibody BEAS-2B BHK-21 cells binding CD147 cell line COVID-19 COVID-19 patient deficiency detectable disease dose-dependent manner effective effective drug endocytosis enzyme Evolution of SARS-CoV-2 expressed expressing Extracellular facilitate host cell host cell receptor host cells Human Industrial microbiology infected with SARS-CoV-2 Infection inhibit inhibited Interaction intestine kidney lung lung tissue Lungs lymphocyte Lymphocytes Meplazumab mice neutralized property Protein provide pseudovirus receptor reported reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein Spike protein T cell T cells today Vero E6 Viral viral loads virion virions virus virus entry virus infection wild type
[DOI] 10.1038/s41392-020-00426-x PMC 바로가기 [Article Type] Article

Protein-Driven Mechanism of Multiorgan Damage in COVID-19

Research article

Published on 2020-12-012022-10-05
Journal: Medicine in Drug Discovery [Category] 신약개발,

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2

Review Article

Published on 2020-12-012022-10-29
Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS,

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Article

Published on 2020-11-182022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,

[키워드] accumulated acute respiratory syndrome characteristic characterized cisternae complexes conformational change coronavirus COVID19 Critical Cryoelectron microscopy Cryoelectron tomography cylindrical cytoplasm double-stranded RNA Extracellular filament Genome highly pathogenic induce mechanism membrane membrane curvature membranes occur other coronaviruses packaged pandemic recruitment replicate Replication representing ribonucleoprotein RNA RNA secondary structures S trimer SARS-CoV-2 SARS-CoV-2 infected cell steric tomography vesicles viral replication virion virion assembly virus virus replication β-coronavirus
[DOI] 10.1038/s41467-020-19619-7 PMC 바로가기 [Article Type] Article