Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions경증 및 무증상 COVID-19 회복기 조절 기능을 보유한 호중구 하위 집합과 관련된 면역 억제의 장기 엔도타입 제시Immunology Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated addition affecting Analysis anti-CD3 anti-SARS-CoV-2 Asymptomatic Asymptomatic COVID-19 asymptomatic infection autologous Blood Cancer CD8 Cell Complication Concentration convalescent convalescent sera coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 convalescents described disease elevated endotype enrolled expansion FACS function functions GM-CSF granulocyte-macrophage colony stimulating factor (GM-CSF) Granulocytic granulocytic myeloid-derived suppressor cells (PMN-MDSCs) healthy donor IgG immune response Immunosuppression immunosuppressive Infection inhibit long-COVID low-density low-density neutrophils (LDNs) lymphopenia mAb Mild myeloid cell myeloid cells NDN Neutralizing Neutralizing antibodies neutrophil neutrophil dysfunction Neutrophils normal density neutrophils past PCR test PD-L1 positive result present proliferation Propagation Regulatory responsible SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severe lymphopenia significantly higher subpopulation suppressor cells T cell T cells T-cell tendency These cells was used were used Whole blood [DOI] 10.3389/fimmu.2021.748097 PMC 바로가기 [Article Type] Immunology
Hospital preparedness during epidemics using simulation: the case of COVID-19Article Published on 2021-09-272022-10-31 Journal: Central European Journal of Operations Research [Category] COVID-19, [키워드] Admission Bed occupancy Care caused component conducted COVID-19 COVID-19 pandemic Discrete event simulation model Epidemics functions Gompertz growth model growth Health healthcare hospital Hospital resources planning Hospitalization ICU initial intensive care unit Logistic mimicking Outbreaks pathway Patient positive provide Region resource resulting Spain Spread Stage Support virus [DOI] 10.1007/s10100-021-00779-w PMC 바로가기 [Article Type] Article
Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insightSARS-CoV2 NSP12(RNA 의존성 RNA 폴리머라제)에 대한 비뉴클레오사이드 항바이러스제의 용도 변경: 인 실리코 분자 통찰력Article Published on 2021-09-242022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral target binding drug Drug discovery Drug repurposing effort enzyme FDA approved drug function functions inhibit inhibition Measures molecular molecular dynamic simulations new virus Nsp12 nucleoside pandemic Protein RdRP RdRp inhibitor Replication repurposing Research retained RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 screened Viral RNA Virtual screening virus while [DOI] 10.1016/j.bbrc.2021.07.050 PMC 바로가기 [Article Type] Article
LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic ComplicationsImmunology Published on 2021-09-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory distress Alpha ARDS association BAL Blood Bronchoalveolar lavage CD10 CD123 CD64 Clinical characteristics Clinical severity Complication complications COVID-19 COVID-19 patient COVID-19 severity Critical Cytokine storm Cytometry death develop disease severity expressing Factors function functions help high risk ICU ICU patient IL-1β IL-6 IL-8 immature neutrophil independent Infectious diseases Innate immunity intensive care unit invasive ventilation investigated marker neutrophil Neutrophils non-ICU patients objective oxidized pandemic Patient patients patients with ARDS PD-L1 plasma positively correlated Prognostic value proportion receptor remained Result severe COVID-19 patients severity subset syndrome thrombosis TNFα validation study [DOI] 10.3389/fimmu.2021.752612 PMC 바로가기 [Article Type] Immunology
Skin manifestations associated with systemic diseases – Part I ☆ ☆☆Continuing Medical Education Published on 2021-09-172022-10-28 Journal: Anais Brasileiros de Dermatologia [Category] Coronavirus, MERS, SARS, [키워드] alteration biopsies cause Combination condition cutaneous manifestation Dermatology dermatomyositis described Diagnosis diagnostic disease Diseases eye functions group hematological Histopathology hypothese Infection Intention manifestation occur organ Part patients Protective provide pruritus Pyoderma gangrenosum raise recognize reflect renal sarcoidosis SARS-CoV-2 coronavirus skin manifestation Sweet syndrome systemic disease systemic diseases systemic lupus erythematosus Systemic scleroderma the disease variety Vascular Vasculitis [DOI] 10.1016/j.abd.2021.02.008 PMC 바로가기 [Article Type] Continuing Medical Education
Central Nervous System Injury in Patients With Severe Acute Respiratory Syndrome Coronavirus 2: MRI FindingsNeurology Published on 2021-09-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abnormality Brain Central nervous system central nervous system injury changes in CNS coronavirus coronavirus disease correlations COVID-19 Demyelination diagnosis of COVID-19 disease Encephalopathy finding frontal lobe functions histological Hospitalized Infection intensity lack leukoencephalopathy Lineage magnetic resonance MRI multisystemic nervous neurologic neurological deterioration olfactory bulbs osmotic outbreak pandemic Patient patients patients with SARS-CoV-2 performed Pneumonia progression repeated respiratory RT-PCR SARS-CoV-2 Symptom syndrome System target thrombosis tumors Venous thrombosis was performed World Health Organization [DOI] 10.7759/cureus.18052 PMC 바로가기 [Article Type] Neurology
The development and improvement of ribonucleic acid therapy strategiesReview article Published on 2021-09-142022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 비임상, [키워드] activating addition Affect Antisense oligonucleotides AONs backbone binding affinity catalytic cellular chemical modification COVID-19 delivery vehicle drugs functions Gene Expression IMPROVE limitation microRNA miRNA miRNAs Modification oligonucleotide overcome regulate ribonucleic acid therapy RNA RNA interference RNA vaccine RNA vaccines siRNA siRNAs therapeutic therapeutic drug therapeutic mechanism therapy Toxicity Transcription translation [DOI] 10.1016/j.omtn.2021.09.002 [Article Type] Review article
Metabolic requirements of NK cells during the acute response against retroviral infectionArticle Published on 2021-09-102022-10-29 Journal: Nature Communications [Category] Coronavirus, SARS, [키워드] acute response acute viral infection alteration Amino acid amino acid transporter Antimicrobial responses Antiviral antiviral activity antiviral immunity Cancer Cell change deficiency dysfunction Effect Friend functions Glycolysis HIV Immune cell implication Infection infections Innate lymphoid cells metabolic metabolism mitochondrial metabolism natural NK cell NK cell response NK cell responses NK cells obesity Responder Retroviral infection retrovirus SARS-CoV-2 Signal transduction Specific Transport viral infection viral infections viral loads [DOI] 10.1038/s41467-021-25715-z PMC 바로가기 [Article Type] Article
Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 VirusArticle Published on 2021-09-082022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Affinity purification Analysis antiviral strategy binding biogenesis calu-3 cells caused cellular complex damaged EIF2AK2 functions G3BP1 global pandemic HEK293T human cell human cells Infection interaction partner interactome MOV10 multifunctional N protein nucleocapsid protein Pathogenesis Protein public health responses ribonucleocapsid ribonucleoprotein ribosome biogenesis RNA SARS-CoV-2 SARS-COV-2 infection small subunit the N protein the SARS-CoV-2 Transcription translation TRIM25 viral genome replication viral–host interactome virus ZC3HAV1 ZCCHC3 [DOI] 10.3390/pathogens10091155 PMC 바로가기 [Article Type] Article
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionCOVID-19는 내피 장벽 기능 장애를 직접 유도하는 히알루로난 단편을 생성합니다Research Article Published on 2021-09-082022-09-12 Journal: JCI Insight [Category] 진단, [키워드] activity analyzed CD44 circulating circulation Clinical severity Complication contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical illness damaged Degradation degrade disease dysfunction dysregulated endothelial Endothelial cell enzyme Enzymes Evidence exacerbating Extracellular matrix functions generate glycobiology glycocalyx glycosaminoglycan Hyaluronan hyaluronidase induce Inflammatory cytokine Injury moderate moderate to severe morbidity Organ failure pathologic pathology patients with COVID-19 plasma Protective provide pulmonary regulate released Sepsis Severity of disease significantly Vascular Vascular Biology Vascular injury [DOI] 10.1172/jci.insight.147472 PMC 바로가기 [Article Type] Research Article