hACE2 – Page 18 – Communicable Diseases Research

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Article

Published on 2021-08-122022-10-04
Journal: Cell Discovery [Category] 변종, 치료제,

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

인간 세포 기반 SARS-CoV-2 백신은 강력한 중화 항체 반응을 유도하고 SARS-CoV-2 공격으로부터 마우스를 보호합니다

Research Article

Published on 2021-08-122022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration ameliorated Antibody titer approach caused Cell cell-based vaccines cellular convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated develop effective Efficacy elicit exposure to external gene external genes formalin generate greater hACE2 human cell immunization in viral inactivated Inactivated vaccine induce K562-S Log reduction lung Lung pathology membrane MERS-CoV mice mouse model NAb neutralizing antibody Neutralizing antibody response Neutralizing antibody titer non-human primate non-human primate model non-human primates pandemic platform promise PROTECT protection Protective Protein regimen respiratory response S-protein Safe SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus spike Support turn vaccination Vaccine vaccine candidate vectors viability Viral X-ray
[DOI] 10.1080/22221751.2021.1957400 PMC 바로가기 [Article Type] Research Article

Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19

중증 COVID-19의 경우 신종 감염병에 대한 마우스 모델의 신속한 생성

Research Article

Published on 2021-08-112022-09-12
Journal: PLoS Pathogens [Category] MERS, 진단,

Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model

경증 및 중증 SARS-CoV-2 감염은 K18-hACE2 형질전환 마우스 모델에서 호흡기 및 장내 미생물군유전체 변화를 유도합니다

Research Article

Published on 2021-08-112022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 치료제,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Antiviral Antiviral treatment Bacteroidete Bacteroidetes cecum change changes in characterized Clinical sign Clinical signs coronavirus COVID-19 COVID-19 pandemic death deaths declining Decreased develop disease dissimilarity dosage dose dose-dependent manner family Firmicute firmicutes groups hACE2 High dose High-dose immune system increasingly independent independent of Infection inhibitor intestinal intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice less lung Lungs M pro mice microbe microbes microbial Microbiome Model mouse presence or absence prevalent Proteobacteria respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 significantly Treatment Verrucomicrobia Viral viral infections virus with infection
[DOI] 10.1128/Spectrum.00536-21 PMC 바로가기 [Article Type] Research Article

Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor

Communication

Published on 2021-08-102022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] absence ACE2 acute respiratory syndrome Analysis bind binding blocking Candidates caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics demonstrated effective Effectiveness Elaeocarpus sylvestris entry of SARS-CoV-2 enzyme-linked immunosorbent geraniin hACE2 hACE2 receptor high affinity Human human Angiotensin-converting enzyme human cells human epithelial cells indicated ingredient inhibit Interaction investigated natural pandemic plant Protein Proteins RBD receptor residue SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome coronavirus 2 spike Spike protein the SARS-CoV-2 the spike protein therapeutic treating COVID-19 Vaccines VAR viral entry virus entry
[DOI] 10.3390/ijms22168604 PMC 바로가기 [Article Type] Communication

Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

SARS-CoV-2에 대한 강력한 인간 중화 항체의 식별이 치료제 및 예방 개발에 미치는 영향

Article

Published on 2021-08-092022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Administered Analysis angiotensin anti-SARS-CoV-2 Anti-viral treatment antibodies antibody Applying Candidates coronavirus detectable determinate Diseases domain drug Economy effective drug effective drugs Emerging infectious diseases epitope Epitopes Fab germline global public health hACE2 high affinity human Angiotensin-converting enzyme identification identify Impact implication infected patient infected patients Infectious diseases Lung injury maturation mechanism mice monoclonal antibodies monoclonal antibody naïve neutralize Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody Novel coronavirus platform Prophylactic prophylactically RBD reduce respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein the RBD the SARS-CoV-2 therapeutic Vaccines Viral viral infection viral titer
[DOI] 10.1038/s41467-021-25153-x PMC 바로가기 [Article Type] Article

Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2

SARS-CoV-2의 출현과 관련된 재조합 및 계통 특이적 돌연변이

Research

Published on 2021-08-062022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종,

[키워드] accompanied adaptation affecting affinity Algorithm allele alleles analyses ancestor ancestors Betacoronavirus Betacoronavirus genus binding binding affinity clade event Evidence evidence of hACE2 helix host cell Human human ACE2 humans in silico include indicate infect information insertion interact MERS MERS-CoV Mutation Phylogenetic Protein protein level RBD receptor Receptor binding affinity Receptor binding domain receptors Recombination recombination event reconstruction responsible Result resulting SARS-CoV SARS-CoV-2 sequence significantly Spike protein strain supplementary material the RBD the Spike variant variants Viral virus viruses was used zoonosis zoonotic
[DOI] 10.1186/s13073-021-00943-6 PMC 바로가기 [Article Type] Research

The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19

Research Article

Published on 2021-08-032022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome Ad5-hACE2 airway epithelia angiotensin-converting enzyme 2 bind Calu-3 camostat Camostat mesylate caused Cell cell line cleaved coronavirus coronavirus disease COVID-19 disease pathogenesis entry of SARS-CoV-2 epithelia exhibiting greater hACE2 host cell human ACE2 in vivo Infection inhibit inhibitors initiate intranasal K18 K18-hACE2 limit lung tissue membrane fusion MERS-CoV mice Middle East Model morbidity and mortality Mortality mouse Mouse models nafamostat pandemic pathogenic coronavirus preclinical drug studies primary human airway Prophylactic protease Protease inhibitor protease TMPRSS2 Protective pulmonary receptor reduced respiratory syndrome coronavirus respiratory tract SARS-CoV-2 SARS-COV-2 infection serine protease serine protease inhibitors significantly Spike protein tested the spike protein TMPRSS2 transgenic mice Treatment viral burden weight loss
[DOI] 10.1128/mBio.00970-21 PMC 바로가기 [Article Type] Research Article

N439K Variant in Spike Protein Alter the Infection Efficiency and Antigenicity of SARS-CoV-2 Based on Molecular Dynamics Simulation

Cell and Developmental Biology

Published on 2021-08-032022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

전임상 평가를 통해 SARS-CoV-2 및 이의 변이체에 대한 범-CoV 융합 억제제에 대한 구조 및 기능 기반

Article

Published on 2021-07-292022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 신약개발, 치료제,

[키워드] (alpha administration African Alpha animal models antiviral activity antiviral agent Antiviral agents B.1.1.7 Caco2 Calu Calu-3 Cell fusion cell line cell lines cholesterol clinical development COVID-19 pandemic crystal structure D614G E484K Economy effective functional Gamma hACE2 HR1 domain Infection Infectious diseases inhibitor inhibitors intestinal tissues lung Mutation N501Y peptide peptides pseudotyped SARS-CoV-2 public health reduced S protein safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 variant significantly South structural biology target the SARS-CoV-2 transgenic mice Vaccines variant variants Viral viral titer viral titers
[DOI] 10.1038/s41392-021-00712-2 PMC 바로가기 [Article Type] Article