healthy individuals

[키워드] activated activating Activation acute COVID-19 acute respiratory syndrome acute viral infection adaptive immune responses affected Analysis Antiviral antiviral response approach available data B cell responses B cell subset B cells Blood caused CD38 CD4 CD4 T cells CD8 CD8 T cell CD8 T cells cells characteristic characterized circulating Clinical data clinical feature Clinical features clinical outcomes collected comparable complex component controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 severity Cytometry declined deep dimension disease disease severity Donor dysregulation Effective vaccines effector memory exacerbate fatality feature Features flow cytometry fluctuation follicular global pandemic Health healthy donor healthy individual healthy individuals help HLA-DR Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients human immune response Human immune system identify immune Immune cell immune modulation immune parameter immune profiling immune response immune system immunological immunology immunotype implicated implication in some individuals Infection infections influence information inhibiting less longitudinal analysis lymphocyte lymphocyte response mechanical ventilation memory B cell mononuclear cell occurred parameters Pathogenesis Patient patients performed peripheral plasmablast plasmablast response progression proliferation proportion remained respond response reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–specific antibodies Science severe respiratory disease stability STABLE subgroup of patient subset Systems biology T cell T cell activation T cell response therapeutic therapeutic interventions trajectory Treatment UMAP uninfected Vaccine virus with COVID-19
[DOI] 10.1126/science.abc8511 PMC 바로가기 [Article Type] Research Article