Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatmentsArticle Published on 2014-09-302022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] 2′O-Methyl-transferase 2′O-MTase Antiviral treatment approach component conserved CoV CoV infection CoVs highlight Host immune response identify immune innate immune Interaction manuscript MDA5 MERS-CoV Middle East motif motifs mutant mutants non-structural protein nsp16 Pathogenesis pathway Protein required respiratory SARS-CoV Strains Therapeutic treatment Treatment viruses [DOI] 10.1016/j.virusres.2014.09.009 PMC 바로가기 [Article Type] Article
Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infectionResearch Article Published on 2013-10-302022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis analyzed Antiviral Apoptosis bronchitis cascade cause Cell compared conducted contagious contributed coronavirus cytokine differential expression differentially expressed gene down-regulated Gene Gene expression profiling Genes Host host defense response Host transcriptional response IBV IBV infection identify IL6 immune immune responses immune-related gene Infection infectious Infectious Bronchitis Virus Inflammatory response innate immune Interaction involved IRF1 KEGG pathway kidney kidney tissue kidney tissues knowledge mechanism Microarray molecular MOST MYD88 NFKB2 Ontology Pathogenesis pathway positive provided real-time RT-PCR Regulation related Result Signal transduction Stat1 the Coronaviridae Transcriptome transcriptome analysis up-regulated upper respiratory tract virus [DOI] 10.1186/1471-2164-14-743 PMC 바로가기 [Article Type] Research Article
Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated SignalingResearch Article Published on 2012-02-012022-10-06 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute respiratory syndrome Antiviral block catalytic catalytically active Cell cells complex complexes contributing to coronavirus CoV Defense disrupting Disruption domain Endoplasmic reticulum evade expressing expression form found HCoV-NL63 Host IFN IKKε inactive Infected inhibit Innate innate immune innate immune response interferon MAVS mechanism membrane mutant NL63 nuclear translocation Papain-like protease PLP promoters Protein reduced regulate required response RIG-I SARS-CoV Signaling signaling molecule subsequent TBK1 wild type [DOI] 10.1371/journal.pone.0030802 PMC 바로가기 [Article Type] Research Article
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexResearch Article Published on 2011-10-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus [DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegansCaenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn [DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoVResearch Article Published on 2008-12-122022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 2003 absence adapter addition animal model antiviral therapies Atypical Author BALB/c mice C57BL/6 caused Cell characterized chemokine Chemokine receptor chest X-ray China circulating Clinical course compared contribute coronavirus coronavirus correlated Course CoV death disease disease pathogenesis early response exhibited expression Factor function Genetic greater Host host gene Host immune response humans identify immune immune system Infection Inflammatory Inflammatory response innate immune intranasal Laboratory lethal Lower respiratory tract lung Lung inflammation lung tissue Lungs mice monocyte monocytes/macrophage Mortality mouse-adapted SARS-CoV Pneumonia Post-infection Proinflammatory cytokine protection Protein provide Pulmonary pathology receptor recruitment Replication required respiratory virus respond SARS-CoV SARS-CoV infection severe lung pathology Signaling significantly higher Spread susceptible TLR Travel Viral load viral loads viral replication virus virus wild-type [DOI] 10.1371/journal.ppat.1000240 PMC 바로가기 [Article Type] Research Article
Avian Influenza: Should China Be Alarmed?Review Article Published on 2007-08-312023-05-31 Journal: Yonsei medical journal [Category] 조류인플루엔자, [키워드] adaptive immune Avian Influenza Control H5N1 innate immune prevention [DOI] 10.3349/ymj.2007.48.4.586 PMC 바로가기 [Article Type] Review Article