Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018Research Published on 2021-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] acute respiratory syndrome animal model Betacoronavirus characterized coronavirus experiments Human infect isolate MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mutation outbreak pathogenicity phenotype profiles reduced replication kinetics respiratory respiratory infections respiratory syndrome coronavirus responsible SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe respiratory illness stability strain Strains surface‒aerosol stability Surveillance Variation viruses zoonoses [DOI] 10.3201/eid2712.210344 PMC 바로가기 [Article Type] Research
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein천연물 화합물은 보존된 Nsp9 SARS-CoV-2 단백질에 결합하여 시험관 내 코로나바이러스 복제를 억제합니다Article Published on 2021-12-012022-09-11 Journal: The Journal of Biological Chemistry [Category] SARS, 치료제, [키워드] affinities antiviral activity Antiviral compound approach assays bind binding C-terminal cellular complex Compound conserved Coronaviral crystal structure cytotoxic domain dose facilitate in vitro Infection inhibit kaurane MERS-CoV molecular Nsp12 Nsp9 oridonin predominant preliminary finding Protein purified reduce reducing Replication replication transcription complex. SARS-CoV-2 SARS-CoV-2 protein substrate Transcription viral titer [DOI] 10.1016/j.jbc.2021.101362 PMC 바로가기 [Article Type] Article
Fiber-optic label-free biosensor for SARS-CoV-2 spike protein detection using biofunctionalized long-period fiber grating생체 기능화된 장기 섬유 격자를 사용한 SARS-CoV-2 스파이크 단백질 검출을 위한 광섬유 라벨이 없는 바이오센서Article Published on 2021-12-012022-09-11 Journal: Talanta [Category] SARS, 치료기술, [키워드] ambient ambient temperature antibody caused changes in concentrations coronavirus COVID-19 demonstrated detect develop diagnostic methods exhibited faster fiber Local Long-period fiber grating MERS-CoV Modification offer optical phase Phase shift protein concentration refractive index SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein Spike protein stability surface surface functionalization temperature transport medium Variation variations virus transport medium widespread [DOI] 10.1016/j.talanta.2021.122801 PMC 바로가기 [Article Type] Article
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication423 Published on 2021-11-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding [DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423
COVID-19 vaccine confidence and hesitancy among health care workers: A cross-sectional survey from a MERS-CoV experienced nationResearch Article Published on 2021-11-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Anxiety Candidates Care center Control coronavirus disease COVID COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cross-sectional cross-sectional survey Factor HCW HCWs Health Health care worker identify knowledge less Logistic regression analysis male MERS-CoV MOST National objective outcome pandemic patients prevention questionnaire receive Result Saudi Arabia significantly the vaccine vaccination Vaccine was measured website [DOI] 10.1371/journal.pone.0244415 PMC 바로가기 [Article Type] Research Article
Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus DetectorBioengineering and Biotechnology Published on 2021-11-262022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] approach biosensor broadly neutralizing antibodies can be used coronavirus COVID-19 detect Detector diagnostic effective fiber human coronavirus immunization MERS-CoV neutralizing antibody optical Optical fiber optics pandemic Pandemics public health resource SARS-CoV SARS-CoV-2 spike Strains therapeutic threat Threats turn Universal Vaccine virus viruses [DOI] 10.3389/fbioe.2021.637715 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine CoronavirusPathogenesis and Immunity Published on 2021-11-242022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] Accessory accessory protein accessory protein 8b accessory proteins addition Affect antiviral immune response beta coronavirus C-terminal contribute coronavirus CoV CoVs demonstrated ENCODE Endoplasmic reticulum ENhance enhanced Essential expressing FIVE Genome global public health Hepatitis high variability Host IFN-I in vitro in vivo infected cells inhibit inhibitory effect innate immune response Innate immunity interfere introduced membrane MERS-CoV MERS-CoV infection methionine MHV mice Middle East mouse mouse hepatitis virus Multiple murine N-terminal domain not affect ORF8b Pathogenesis Protein protein 3 Region regulate renal Replication respiratory respiratory syndrome coronavirus responsible RNA-seq analysis SARS-CoV SARS-CoV-2 severe pneumonia severe respiratory infection shown significantly threat type I interferon variant viral replication Viral virulence virulence virus [DOI] 10.1128/JVI.01842-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Cross-reactive antibodies after SARS-CoV-2 infection and vaccinationSARS-CoV-2 감염 및 예방접종 후 교차 반응 항체Research Article Published on 2021-11-232022-10-31 Journal: eLife [Category] COVID-19, SARS, 파상풍, [키워드] addition antibodies antibodies binding antibody convalescent sera coronavirus COVID-19 cross-reactive antibody cross-reactivity current Efficacy feasibility Guidance HCoV healthy donors Human human coronavirus humans increase in investigated macaque MERS-CoV Novel coronavirus Other Outbreaks PROTECT protective vaccines Protein response S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine specificity Support the S protein vaccination Vaccine variant [DOI] 10.7554/eLife.70330 PMC 바로가기 [Article Type] Research Article
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
Pregnancy as a Risk Factor of Severe COVID-19Review Published on 2021-11-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome age Asymptomatic caused change changes in claimed coronavirus coronavirus disease 19 Course COVID-19 COVID-19 mortality death Effect Epidemics etiological agent Factor global pandemic healthcare higher risk highlight ICU admission mechanical ventilation MERS-CoV morbidities other coronaviruses outcome pandemic pathophysiology physiological Pregnancy pregnant women Prophylaxis SAR-CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 Infection subcellular Symptoms synergistic the SARS-CoV-2 Treatment understanding Vaccine with COVID-19 women [DOI] 10.3390/jcm10225458 PMC 바로가기 [Article Type] Review