A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling
Research Article
[키워드] Activation
Alpha
antibody
AOSD, adult-onset Still's disease
bind
blockade
Candida albican
characterized
complex
COVID-19
COVID-19 patient
COVID-19 patients
cultures
Cytokine storm
Diseases
downstream
DSS, dextran sodium sulfate
elevated
exhibiting
high mortality
human cell lines
humanized
IBD, Inflammatory bowel disease
IFNγ
IFNγ
IL-1
IL-1 receptor 7 (IL-1R7)
IL-18
IL-18, interleukin-18
IL-6
Inflammation
inflammatory signaling
inhibited
initiate
Interleukin-18
interleukin-18 (IL-18)
LPS
macrophage activation syndrome
macrophage activation syndrome (MAS)
MAS, macrophage activation syndrome
modulate
monoclonal
mononuclear cell
NFκB
PBMC, peripheral blood mononuclear cell
PBMCs
Peripheral blood
Proinflammatory cytokine
receptor
recruitment
reduce
reduced
resulting
severe disease
severity of COVID-19
sHLH, secondary hemophagocytic lymphohistiocytosis
Signaling
significantly
suppressed
Symptoms
systemic and local
systemic hyperinflammation
therapeutic
therapeutic strategy
TIR, Toll-IL-1 receptor
TNFα
TNSB, trinitrobenzoic sulfonic acid
Whole blood
[DOI] 10.1016/j.jbc.2021.100630 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1016/j.jbc.2021.100630 PMC 바로가기 [Article Type] Research Article