pro-inflammatory cytokine – Page 18 – Communicable Diseases Research

Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort study

SARS-CoV2에 감염된 환자의 혈청에서 키누레닌 대 트립토판 비율 증가: 관찰 코호트 연구

Observational Study

Published on 2021-03-012022-09-11
Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 바이오마커, 임상,

Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review

NF-κB의 하향 조절을 위한 희귀 약물의 재배치를 위한 COVID-19의 과도한 면역 반응 이해: 체계적인 검토

Review

Published on 2021-02-272022-09-10
Journal: Viruses [Category] MERS, 신약개발,

[키워드] adult COVID-19 patients article Autopsies biopsies clinical trial clinical trials country COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines demonstrated downstream drug effector eligibility English excess excess immune response Final Histamine histamine-conjugated-normal human immunoglobulin human immunoglobulin hyper-inflammation IL-10 IL-6 immune response Immunoglobulin immunological inhibit interleukin Joanna lack mechanism molecule molecules morbidity morbidity and mortality neutralization NF-κB nuclear translocation Orphan pathway pro-inflammatory cytokine pro-inflammatory cytokines reposition repositioning response resulting review Risk of bias SARS-CoV-2 screened searched Side effects Signaling specificity Therapeutics TNF-α TNFα tumour necrosis factor Tumour Necrosis Factor α upstream were used
[DOI] 10.3390/v13030378 PMC 바로가기 [Article Type] Review

The pulmonary pathology of COVID-19

Review and Perspectives

Published on 2021-02-192022-10-29
Journal: Virchows Archiv [Category] COVID-19, MERS,

[키워드] affected Angiogenesis Autopsies Autopsy caused change characterized COVID-19 cytokine level D-dimer DAD death decrease described Diffuse alveolar damage disease stage disease stages disorder edema elevated epithelial fatal COVID-19 feature Features Frequency group hyaline membrane formation hypercoagulability lung lung damage Lung pathology lymphopenia majority massive secretion novel coronavirus SARS-CoV-2 organ pathophysiology Patient patients pro-inflammatory cytokine pulmonary disease Pulmonary pathology question SARS-CoV-2 severe coronavirus disease severe COVID-19 Thromboembolic events thrombotic tissue repair viral infections Viral load virus load
[DOI] 10.1007/s00428-021-03053-1 PMC 바로가기 [Article Type] Review and Perspectives

A review on function and side effects of systemic corticosteroids used in high-grade COVID-19 to prevent cytokine storms

Review Article

Published on 2021-02-152022-10-31
Journal: EXCLI Journal [Category] COVID-19,

[키워드] 2019-nCoV acute respiratory syndrome adverse effects caused chemokine China clinical trial Cluster coronavirus Corticosteroid corticosteroid therapy Corticosteroids COVID-19 COVID-19 infection COVID-19 patient Cytokine storm demonstrated Dexamethasone drug Effectiveness Efficacy immune responses Inflammation inhibit inhibition of inflammation lung mechanical ventilation Methylprednisolone Novel coronavirus occur pathogen Phase 3 Pneumonia Prevent pro-inflammatory cytokine protocol resulting SARS-CoV-2 Side effect Side effects single-stranded RNA virus suppress systemic corticosteroid systemic inflammatory response the cytokine storm therapeutic viral infection Wuhan
[DOI] 10.17179/excli2020-3196 PMC 바로가기 [Article Type] Review Article

Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19

Immunology

Published on 2021-02-122022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] accelerated alteration Antiviral effect application autophagy Azithromycin benefit clearance Clinical use contribute Course COVID-19 COVID-19 immune response COVID-19 pandemic Cytokine storm death defined early stage Effect effective Efficacy Evidence Factor function identify immune mechanism immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory therapy immunosuppressive Infection Inflammation inflammatory cell infiltration investigated late stage Lung pathology macrophages mechanism Multiple neutrophil patients patients with COVID-19 Potential pro-inflammatory cytokine progression pursuit Regulatory severe disease shown Stage Support the disease therapeutic therapy viral burden virus while
[DOI] 10.3389/fimmu.2021.574425 PMC 바로가기 [Article Type] Immunology

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

Article

Published on 2021-02-062022-10-30
Journal: iScience [Category] COVID-19,

[키워드] Abstract acute respiratory syndrome Analysis Biological Biological sciences Calu-3 coronavirus COVID-19 Disease progression elicited epithelial cell line epithelial cells expression gene expression profile Genes Heat shock host responses Hsp90 human cell line human cell lines identify IL-6 impair infected cell infected cells Infection inhibition inhibitor innate immune response interferon interferon regulatory factor knowledge Molecular biology NF-kB nuclear omics primary human airway pro-inflammatory cytokine pro-inflammatory gene Protein reduction RNA sequencing SARS-CoV SARS-CoV-2 subset suggested target gene Temporal therapy transcriptional activity transcriptomics upregulated viral replication Virology virus infection were expressed
[DOI] 10.1016/j.isci.2021.102151 PMC 바로가기 [Article Type] Article

Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) Pathophysiology

Review

Published on 2021-02-052022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] activate Activation acute respiratory syndrome age alteration antiviral response aryl Aryl hydrocarbon receptor Butyrate CD8+ T cells circulating condition conditions Coronavirus-2 COVID-19 COVID-19 pandemic diabete driven by dysregulated Effect EGCG expression level gallate Gut high risk hydrocarbon immune cells immune response Implications increase in increased risk indole Infection inhibit initial LPS macrophages Mast cells melatonin metabolism Mitochondrial function natural killer cell Neutrophils nutraceutical obesity physiological pro-inflammatory cytokine pyruvate Regulation Research respiratory response resveratrol SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome suppresse Treatment Tryptophan
[DOI] 10.3390/ijms22041597 PMC 바로가기 [Article Type] Review

SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages

Research Article

Published on 2021-02-022022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] abrogate activate activated Activation acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine develop Effect examined excessive inflammation experiment exposure to human macrophage human macrophages induce Infectious disease Inflammation Inflammatory inhibitor intracellular signaling involved JNK Macrophage macrophages mechanism Mortality multiple organ failure murine N-terminal neutralizing antibody NF-κB nuclear Pathways Patient pro-inflammatory cytokine pro-inflammatory mediator pro-inflammatory response produced Protein receptor S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein selective severe complication severity Signaling signaling pathways spike Spike protein Spread suggested suppressed the disease THP-1 TLR2 TLR4 toll-like receptor 4
[DOI] 10.1016/j.heliyon.2021.e06187 PMC 바로가기 [Article Type] Research Article

Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19

COVID-19 환자의 복합 요법에서 조혈모세포 분화 활성화제를 사용한 결과 및 전망

Article

Published on 2021-02-012022-09-11
Journal: Stem cell reviews and reports [Category] 유전자 메커니즘,

[키워드] accelerated activator addition biological activity blood clot Blood clots C-reactive protein carbon complex Concentration control group Coronavirus infection COVID-19 COVID-19 patients cytokine D-dimer decrease differentiation hematopoietic Hematopoietic stem cell hematopoietic stem cells Hemostasis hydrogen hydrogen atom hydrogen atoms IL-6 Immunity immunomodulatory effect Inclusion mechanism nitrogen oxygen paper Patient patients with COVID-19 peptide peptides phosphorus pro-inflammatory cytokine pro-inflammatory cytokine IL-6 rationale reduce Result risk SARS-CoV-2 virus shown Standard Standard therapy standard treatment STEM T cell Thymalin. Treatment treatment method with COVID-19
[DOI] 10.1007/s12015-020-10087-6 PMC 바로가기 [Article Type] Article

Acute Symptomatic Seizures in Critically Ill Patients with COVID-19: Is There an Association?

COVID-19가 있는 중환자의 급성 증상성 발작: 연관성이 있습니까?

Case Reports

Published on 2021-02-012022-09-11
Journal: Neurocritical care [Category] 치료기술,

[키워드] 2019 Affect benefit blood-brain barrier Brain Central nervous system clinical Clinical sign Clinical signs Contamination coronavirus coronavirus disease cortical COVID-19 COVID-19 disease cross-contamination cytokine disease Disseminated intravascular coagulopathy elevated Encephalopathy epilepsy global pandemic health system Hospitalization human coronavirus human coronaviruses Ill Infection Injury levetiracetam Lung disease male mechanism motor multifactorial neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms neurotropic Organ failure Patient patients patients with COVID-19 positive precipitated pro-inflammatory cytokine Reactions reported Resolution resources respiratory risk SARS-CoV-2 secondary to Seizure Seizures severe COVID-19 disease status epilepticus symptomatic tested therapy thought Viral viral infection with COVID-19
[DOI] 10.1007/s12028-020-01006-1 PMC 바로가기 [Article Type] Case Reports