Cryo-EM structures of human bradykinin receptor-G q proteins complexesArticle Published on 2022-02-072022-10-04 Journal: Nature Communications [Category] 변종, [키워드] acting Activation agonist binding cardiovascular system complex complexes conformational change conserved Cryo-electron microscopy cryo-EM cryo-EM structure Cryoelectron microscopy determine dysfunction G protein-coupled receptor G protein-coupled receptors Glutamate induce Inflammation Interaction Ligand mechanism molecular mechanism motifs Pain peptide peptides PROTECT Protein Proteins receptor Receptor pharmacology Structure Type [DOI] 10.1038/s41467-022-28399-1 PMC 바로가기 [Article Type] Article
Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury중증 SARS-CoV-2 감염 관련 심근 손상의 발병에서 혈소판-내피 상호작용의 새로운 역할Review Published on 2022-02-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Abnormalities ACE2 ACE2 receptor activated Activation activation of platelets Acute cardiac injury acute infection acute myocardial injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin angiotensin-converting enzyme 2 arrhythmia calcium calcium-binding proteins cardiac complication Cardiac complications cardiac disorders cardiac injury cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular dysfunction Clinical course Clinical outcome Coagulation contribute corona virus disease (COVID-19) coronavirus defined described disease disease pathogenesis driven by dysfunction endothelial Endotheliitis event fatal complication hypercoagulability include Infection Inflammation Interaction mechanism morbidity and mortality MOST Myocardial myocardial injury nucleocapsid nucleocapsid (N) protein occur oxygen pandemic Patient Platelet platelet activation Platelets potential mechanism potential mechanisms Prevalence Proteins respiratory risk factor Risk factors role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus Sepsis severe acute respiratory syndrome Coronavirus severe disease significantly Spike protein systemic inflammation the SARS-CoV-2 virus triggering turn Vascular endothelium Viral viral spike protein virus [DOI] 10.3389/fimmu.2022.776861 PMC 바로가기 [Article Type] Review
Rapid cGMP manufacturing of COVID-19 monoclonal antibody using stable CHO cell pools안정적인 CHO 세포 풀을 사용하여 COVID-19 단일 클론 항체의 신속한 cGMP 제조Article Published on 2022-02-012022-09-11 Journal: Biotechnology and bioengineering [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] accelerated activities acute respiratory syndrome acute respiratory syndrome coronavirus approach Cell cell bank Cell culture cGMP cGMP manufacturing CHO cell CHO pools clinical trial clone comparability coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical demonstrated Final generate host cell material monoclonal antibodies monoclonal antibody pandemic performed Phase 1 Phase 1 clinical trial Proteins provided Rapid respiratory subsequent supply Testing timeline transposase [DOI] 10.1002/bit.27995 PMC 바로가기 [Article Type] Article
The Impact of COVID-19 on Liver InjuryReview article Published on 2022-02-012022-10-05 Journal: The American journal of the medical sciences [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] acute respiratory distress antiviral drug ARDS cause coronavirus disease COVID-19 COVID-19 patients Cytokine storm epidemiological Features global pandemic hepatic injury highlight Hypoxemia Impact Infection Inflammatory Liver damage Liver disease liver dysfunction Liver injury Liver transaminases Lung injury management Mortality outbreak Pathogenesis patients with COVID-19 Prognostic factor Proteins reported SARS-CoV-2 viral severity syndrome the disease [DOI] 10.1016/j.amjms.2021.11.001 [Article Type] Review article
Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy새로운 바이러스 변종, 획기적인 감염 및 백신 주저에 직면하여 Covid-19 완화Review Published on 2022-02-012022-09-11 Journal: Journal of autoimmunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Antibody Response approach B cell B cell memory being booster Breakthrough infection breakthrough infections Cell condition conserved COVID-19 virus creating Critical death Delta disease effective evade facilitate follicular Germinal center Global vaccination helper cells Hospitalization Immunity immunization Interaction multivalent vaccine mutate Mutation notable omicron Omicron variant Omicron variants pandemic Perspective Proteins public health emergency resulting RNA RNA virus robust SARS-CoV-2 Second-generation vaccines Spread T follicular helper cells the antibody response translational Transmissibility Transparency vaccination Vaccine Vaccine hesitancy Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations Viral protein Viral proteins virus virus variants [DOI] 10.1016/j.jaut.2021.102792 PMC 바로가기 [Article Type] Review
Designing of peptide aptamer targeting the receptor-binding domain of spike protein of SARS-CoV-2: an in silico studySARS-CoV-2의 스파이크 단백질 수용체 결합 도메인을 표적으로 하는 펩타이드 앱타머 설계: in silico 연구Article Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] ACE2 albumin antibodies approach aptamer ATP Bacterial bind CD4 complex coronavirus docked domain ENCODE envelope Genome high affinity host cell in silico membrane metal ions molecular molecular docking molecular dynamic simulation monoclonal antibodies non-allergenic non-hemolytic nucleocapsid peptide Peptide aptamer predicted Protein Proteins Receptor-binding domain SARS-CoV-2 scaffold protein serum albumin specificity spike Spike protein spike receptor-binding domain stability target target protein tertiary structure the receptor-binding domain theophylline Therapeutic treatment thioredoxin thrombin virus [DOI] 10.1007/s11030-020-10171-6 PMC 바로가기 [Article Type] Article
4-Hexylresorcinol: pharmacologic chaperone and its application for wound healingReview Published on 2022-02-012022-10-30 Journal: Maxillofacial Plastic and Reconstructive Surgery [Category] COVID-19, [키워드] 4-Hexylresorcinol addition administration Angiogenesis Anti-inflammatory change chaperone Diabetic Endoplasmic reticulum increase induce inhibit NF-κB pathway Protein Proteins Stress Strong surgical TGF-β1 TNF-α VEGF wound healing wounded [DOI] 10.1186/s40902-022-00334-w PMC 바로가기 [Article Type] Review
In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune SystemsMedicine Published on 2022-02-012022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Analysis Antigen Autoimmunity binding candidate cellular class Cluster Clustering analysis coagulation cascade complement conserved contribute coronavirus Coronavirus infection COVID-19 COVID-19 pathogenesis dataset Degradation described downregulation Endoplasmic reticulum eukaryote eukaryotic genome sequence homology immune evasion in silico analysis Infection involved Involvement KEGG KEGG pathway analysis less leukocyte ORF8 ORF8 accessory gene ORF8 protein pathology performed Phylogenetic phylogenetic profiling physically predicted promote Protein Proteins SARS-CoV SARS-CoV-2 severe symptom Spread Stress suggested System tissue-specific expression variant of SARS-CoV-2 ward was performed wild-type SARS-CoV-2 [DOI] 10.3389/fmed.2022.824622 PMC 바로가기 [Article Type] Medicine
Feature-extraction and analysis based on spatial distribution of amino acids for SARS-CoV-2 Protein sequencesSARS-CoV-2 단백질 서열에 대한 아미노산의 공간적 분포를 기반으로 한 특징 추출 및 분석Article Published on 2022-02-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Amino acid amino acids Analysis applied autocorrelation calculate collected CoV CoV proteins COVID-19 Critical deaths dissimilarity distribution effective evaluated examined Fractal Fractal dimension Frequency Frequency distribution genomic healthcare facility Hurst exponent identify information linear relationship parameter parameters Prevent protein sequence protein sequences Proteins proteomic Research researcher Result reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 proteins sequence Shannon entropy similarities similarity Spatial arrangement Strains structural proteins the SARS-CoV-2 [DOI] 10.1016/j.compbiomed.2021.105024 PMC 바로가기 [Article Type] Article
Interpretations of SARS-CoV-2 IgM and IgG antibody titers in the seroepidemiological study of asymptomatic healthy volunteers무증상 건강한 지원자의 혈청역학 연구에서 SARS-CoV-2 IgM 및 IgG 항체 역가의 해석Article Published on 2022-02-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abbott acute respiratory syndrome anti-SARS-CoV-2 Antibody test Antibody titer Architect Architect SARS-CoV-2 IgG Asymptomatic asymptomatic individual Asymptomatic volunteers collected combined use coronavirus COVID-19 cutoff value Elecsy Elecsys anti-SARS-CoV-2 Ig elevated Follow-up healthy subjects healthy volunteer iFlash-SARS-CoV-2 IgM and IgG. IgG IgG antibody titer IgG titer IgG titers IgM IgM and IgG Interpretation investigated participant Participants performed positive Proteins RBD RBD protein RBD proteins reactivity Receptor binding domain recruited reflected Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM Sensitivity and specificity Seroepidemiological study serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survey Symptomatic patients titer Tokyo total Ig university [DOI] 10.1016/j.jiac.2021.11.020 PMC 바로가기 [Article Type] Article