Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19모유의 단백질체 분석은 COVID-19에 걸린 산모의 초유에서 영양 및 면역 이점을 나타냅니다Article Published on 2022-06-172022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] adaptive Analysis Antiviral antiviral properties antiviral property benefit Breastfeeding breastmilk casein collected colostrum control group COVID-19 COVID-19 patient COVID-19 patients debate epitope Epitopes Evidence evidence of exhibited glycosylation Health Organization healthy donors Human immune immune-related protein immune-related proteins Immunoglobulin Infant Infection lack mass spectrometry mature milk milk molecular basis mother protective effect Protein proteomics recognizing recommendation risk SARS-CoV-2 significantly higher significantly lower Structure total protein unique upregulated viral entry virus virus transmission whey protein. while with COVID-19 World Health Organization [DOI] 10.3390/nu14122513 PMC 바로가기 [Article Type] Article
Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury공간 영역 분석 프로테옴 지도는 COVID-19 관련 심장 손상의 메커니즘을 보여줍니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Acute cardiac injury acute respiratory syndrome affected Anatomy cardiovascular disease Characteristics Clinical treatment coronavirus coronavirus disease COVID-19 CP: Cell biology CP: Molecular biology Direct dysfunction heart Heart injury histological Inflammation inflammatory cell inflammatory storm Injury knowledge mechanism molecular myocardia Myocardial myocardial and microvessel injury patients with COVID-19 proteome proteomics Quantitative regions reveal SARS-CoV-2 susceptible Treatment Vascular injury virus infection with COVID-19 [DOI] 10.1016/j.celrep.2022.110955 PMC 바로가기 [Article Type] Article
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort studyResearch article Published on 2022-06-092022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust [DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article
Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] antigenic approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines validation variant variants was performed [DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article
Targeted Proteins Reveal Cathepsin D as a Novel Biomarker in Differentiating Hepatocellular Carcinoma from Cirrhosis and Other Liver CancersArticle Published on 2022-06-012023-06-11 Journal: Asian Pacific Journal of Cancer Prevention : APJCP [Category] B형 간염, [키워드] Biomarker cathepsin D HCC Liver cancers proteomics [DOI] 10.31557/APJCP.2022.23.6.2017 PMC 바로가기
SPIKES: Identification of physicochemical properties of spike proteins across diverse host species of SARS-CoV-2Article Published on 2022-05-242023-07-09 Journal: STAR protocols [Category] COVID19(2023년), [키워드] bioinformatics Microbiology proteomics Systems biology [DOI] 10.1016/j.xpro.2022.101460 PMC 바로가기
Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine비활성화된 SARS-CoV-2 백신으로 면역된 건강한 개인의 면역 반응과 관련된 단백질 및 대사체 서명Article Published on 2022-05-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation Adaptive immune response adaptive immune system affected Amino acid amino acids Analysis applied approach Arm Biosynthesis Cohort complement Complement activation CoronaVac COVID-19 dose driving glycine help highlight host response humoral Humoral response identify IgM/IgG immune immune response immune signature Immunity immunization immunized Inactivated vaccine individual innate immune system Interaction mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomics molecular molecular mechanism multifactorial network Phenylalanine proteomics response SARS-CoV-2 SARS-COV-2 infection Serine shown signature Sinovac specific IgM Systems biology TCA cycle threonine Tryptophan tyrosine utility vaccination Volunteer [DOI] 10.3389/fimmu.2022.848961 PMC 바로가기 [Article Type] Article
Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNAArticle Published on 2022-05-132023-07-08 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), [키워드] Kozak sequence ORFs proteomics RNA SARS-CoV-2 structures. [DOI] 10.1093/bib/bbac045 PMC 바로가기
Why Inclusion Matters for Alzheimer’s Disease Biomarker Discovery in PlasmaArticle Published on 2022-05-092024-09-04 Journal: Journal of Alzheimer's disease : JAD [Category] 대상포진, [키워드] African American Alzheimer’s disease Biomarker black discovery Disparities machine learning plasma proteomics race [DOI] 10.3233/JAD-201318 PMC 바로가기 [Article Type] Article
Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-CCOVID-19 유도 MIS-C와 비교하여 COVID-19 ARDS가 있는 어린이의 병태생리학적 경로 차이Article Published on 2022-05-022022-09-11 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, 임상, 치료법, [키워드] Activation affected Analysis ARDS BCR children children with COVID-19 clinical feature Clinical features clinical phenotypes Coagulation complement contribute COVID COVID-19 described determine differentially expressed dysregulation expressed groups healthy children implicated Inflammatory less mass mass spectrometry metabolism MIS-C pathway Pathways performed plasma protein Protein proteomic proteomics retinoid scavenging Spectrometry susceptible Symptoms syndrome with COVID-19 [DOI] 10.1038/s41467-022-29951-9 PMC 바로가기 [Article Type] Article