Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences개별 SARS-CoV-2 RNA 분자의 절대 정량은 감염 역학 및 변이체 차이에 대한 새로운 패러다임을 제공합니다Research Article Published on 2022-01-202022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] B.1.1.7 B.1.1.7 variant cell population cells cellular clinical implications contributing to COVID-19 Degradation detection efficiency displaying early replication early stage early stages effort event exhibit genomes genomic RNA Human Infection mechanism nucleases positive provide quantification quantitation Replication replication kinetics Research RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA molecule significantly single-molecule fluorescence in situ hybridisation smFISH subgenomic RNAs Transcription Transmissibility Transmission variant variant of concern Victoria Viral Viral proteins viral replication Viral RNA viral RNAs viral variant viruses [DOI] 10.7554/eLife.74153 PMC 바로가기 [Article Type] Research Article
Evaluation of Commercial Anti-SARS-CoV-2 Antibody Assays and Comparison of Standardized Titers in Vaccinated Health Care Workers상업용 Anti-SARS-CoV-2 항체 분석 평가 및 예방 접종을 받은 의료 종사자의 표준화된 역가 비교Article Published on 2022-01-192022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott acute respiratory syndrome anti-RBD antibody Antibody titers antigens assays BAU binding bioMérieux calibration Care commercial assays convalescent individuals conversion factor Coronavirus-2 correlated detect DiaSorin dose evaluated Express FIVE HCW Health Health care Health care worker health care workers Health Organization immunization immunoassay include individuals Infection international standard naïve individuals Pearson correlation coefficient provided quantification Quantitative quantitative assay Quantitative assays RBD RBD IgG Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 antibodies sera Seroconversion Siemen Siemens Siemens Healthineer significant difference significant differences spike glycoprotein spike IgG Standard Standardization standardized titers titer vaccination Vaccine Vaccines was used were measured worker World Health Organization [DOI] 10.1128/JCM.01746-21 PMC 바로가기 [Article Type] Article
Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 TrialCOVID-19 백신 접종에서 Elecsys Anti-SARS-CoV-2 S 어세이의 임상적 유용성: mRNA-1273 1상 시험의 탐색적 분석Clinical Trial Published on 2022-01-192022-09-11 Journal: Frontiers in Immunology [Category] 임상, 치료기술, [키워드] 2019-nCoV absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-SARS-CoV-2 S antibody antibody levels automated baseline choice clinical clinical utility collected coronavirus correlated correlation COVID-19 Day detectable dose Elecsy ELISA ELISAs first vaccination geometric mean geometric mean concentration healthy heterogeneous humoral immune response increases in injection International international standard mRNA mRNA-1273 nanoluciferase neutralization test neutralization tests Neutralizing antibodies participant Participants Phase 1 phase 1 trial Protein pseudovirus neutralizing antibody pseudovirus neutralizing antibody assay quantification Quantitative quantitative serology RBD RBD ELISA RBD-specific antibodies RBD-specific antibody Receptor binding domain respiratory Result Roche S-2P Sample SARS-CoV-2 second vaccination Seroconversion seroconverted severe acute respiratory syndrome Coronavirus shown specific antibodies specificity Spike protein the Spike U/mL vaccination Vaccine vaccine-induced antibody response WHO [DOI] 10.3389/fimmu.2021.798117 PMC 바로가기 [Article Type] Clinical Trial
Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic dataArticle Published on 2022-01-192022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] advance Algorithm can be used Cancer cancer cell Cancer genomics Cell cell population cell type classical Computational models dataset defined estimate expression flexible Gene Expression granular heterogeneity identify immune immune response lung tumors mapping marker Proteins quantification Region resolved single cell sequencing Statistical methods tissue transcriptomic data transcriptomics tumors Tumour immunology [DOI] 10.1038/s41467-022-28020-5 PMC 바로가기 [Article Type] Article
Membrane-Based In-Gel Loop-Mediated Isothermal Amplification (mgLAMP) System for SARS-CoV-2 Quantification in Environmental Waters환경 수역에서 SARS-CoV-2 정량화를 위한 막 기반 겔 루프 매개 등온 증폭(mgLAMP) 시스템Article Published on 2022-01-182022-09-11 Journal: Environmental science & technology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 ambient Analysis assays Chain Reaction Concentration Coronavirus-2 COVID-19 pandemic Critical Early detection Endemic environmental quantification of SARS-CoV-2 in milliliters of environmental water samples equipment expected fluorescence detection hydrogel Image processing inhibited Interpretation isothermal amplification labor-intensive LAMP less Loop-mediated isothermal amplification lowest membrane membrane. Milli-Q nine Outbreaks polymerase chain polymerase chain reaction probe quantification Quantitative reverse transcription reverse transcription quantitative polymerase chain reaction RT-LAMP RT-qPCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Surface water Surveillance System water [DOI] 10.1021/acs.est.1c04623 PMC 바로가기 [Article Type] Article
Objective evaluation of deep uncertainty predictions for COVID-19 detectionArticle Published on 2022-01-172022-10-04 Journal: Scientific Reports [Category] 치료기술, [키워드] applied Applied mathematics biomedical engineering Breast cancer Chest Computer science Confusion COVID-19 CXR dataset deep estimate estimates evaluate evaluation metrics experiments generate introduced mechanism objective observé Performance metrics point estimates Preclinical research Predictive previous study problems quantification Quantification method risk shown statistically Statistics transfer [DOI] 10.1038/s41598-022-05052-x PMC 바로가기 [Article Type] Article
A statistical model of COVID-19 testing in populations: effects of sampling bias and testing errors인구에서 COVID-19 테스트의 통계 모델 : 샘플링 편향 및 테스트 오류의 영향Articles Published on 2022-01-102022-09-01 Journal: Philosophical transactions. Series A, Mathematical [Category] MERS, SARS, 진단, [키워드] approach biases combinatorics COVID-19 COVID-19 testing Data science develop Disease prevalence Effect exclusion False negative False positive fatality Infectious disease pandemic positive quantification quantitative framework sample selection statistical model test result Testing type I [DOI] 10.1098/rsta.2021.0121 PMC 바로가기 [Article Type] Articles
A new testing platform using fingerstick blood for quantitative antibody response evaluation after SARS-CoV-2 vaccinationSARS-CoV-2 백신 접종 후 정량적 항체 반응 평가를 위한 손가락 채혈을 이용한 새로운 검사 플랫폼Coronaviruses Published on 2022-01-072022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] 95% CI addition agreement analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-SARS-CoV-2 S1 IgG antibody Antibody Response Antibody testing blood plasma blood sample collected combating component correlated COVID-19 pandemic COVID19 described detected antibody Efficacy evaluated feasibility fingerstick fingerstick blood healthy IgG antibody limit linear Moderna mRNA mRNA vaccine negative neutralization test nucleocapsid Participants Pfizer plaque reduction neutralization Plaque reduction neutralization test platform PRNT Protein quantification Quantitative quantitative immunoassay. SARS-CoV-2 vaccination receiving S1 IgG SARS-CoV-2 SARS-CoV-2 vaccination spike IgG responses Testing vaccinated individuals vaccination vaccine dose vaccine-induced antibodies venous venous blood Volunteer [DOI] 10.1080/22221751.2021.2023328 PMC 바로가기 [Article Type] Coronaviruses
Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 VaccineArticle Published on 2022-01-072022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory syndrome age antibody applied assessment ChAdOx1 clinical response Cohort coronavirus COVID-19 COVID-19 vaccine domain Effectiveness elicited enrolled enzyme-linked immunosorbent first dose GMT healthy control healthy subject Hemodialysis humoral International mRNA-1273 Multiple linear regression NAb neutralization titer Neutralizing antibodies neutralizing antibody Patient patients predict predictor quantification Ratio receiving regression analysis SARS-CoV-2 single dose single-center study the SARS-CoV-2 titer viral spike protein [DOI] 10.3390/jpm12010068 PMC 바로가기 [Article Type] Article
An Imaging and Computational Algorithm for Efficient Identification and Quantification of Neutrophil Extracellular Traps호중구 세포외 트랩의 효율적인 식별 및 정량화를 위한 이미징 및 계산 알고리즘Article Published on 2022-01-062022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Algorithm analyses Analysis Annexin Apoptosis approach Arthritis Asthma Cancer Cell cell death cellomics cells Combination COVID-19 death disease pathology DNA efficient eliminated ELISA ENhance exhibited extracellular trap fixation flow cytometry high content screening identification identify Image imaging immunoblotting impermeable inconsistency increase in Inflammation inhibitor intensities intensity lupus erythematosus Microscopy modulate morphology Multiple Necrosis NET NETosis NETs neutrophil Neutrophil extracellular traps Neutrophils nomenclature non-specific nuclear pathway platform provided quantification respiratory distress rheumatoid arthritis Sepsis single-cell single-cell analysis staining suffered syndrome systemic lupus erythematosus target Therapeutic approach therapeutic approaches [DOI] 10.3390/cells11020191 PMC 바로가기 [Article Type] Article