Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection비타민 D 충분, 혈청 25-하이드록시비타민 D 최소 30ng/mL는 COVID-19 감염 환자의 불리한 임상 결과에 대한 위험 감소Research Article Published on 2020-09-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 25-hydroxyvitamin D analyzed association benefit C-reactive protein C-reactive protein (CRP CDC criteria circulating Clinical outcome clinical outcomes Clinical severity confounding factors COVID-19 COVID-19 infection cytokine Cytokine storm General population help hospital hospitalized patient immune function immune response increase in infected with COVID-19 Infection Inflammatory lymphocyte Lymphocytes marker modulate morbidities morbidity Mortality parameter Patient patients patients older patients with COVID-19 reduced risk reducing reduction in Result risk SARS-COV-2 infection serum serum 25-hydroxyvitamin D serum CRP Serum level Severe COVID-19 Infection severity Study design Viral viral infection Vitamin D Vitamin D status vitamin D sufficiency [DOI] 10.1371/journal.pone.0239799 PMC 바로가기 [Article Type] Research Article
The prevalence of psychiatric symptoms of pregnant and non-pregnant women during the COVID-19 epidemicArticle Published on 2020-09-192022-10-04 Journal: Translational Psychiatry [Category] SARS, 치료기술, [키워드] Anxiety available data caused China Coronavirus disease 2019 covariates COVID-19 COVID-19 epidemic cross-sectional deaths Depression disorder enrolled Health Human behaviour information Insomnia Mental mental health Participants Patient physical Post-traumatic stress disorder Pregnancy pregnant pregnant women Prevalence prevalence rate problem Psychiatric psychological Impact PTSD questionnaire reduced risk severity Symptom symptoms of depression was performed was used women [DOI] 10.1038/s41398-020-01006-x PMC 바로가기 [Article Type] Article
Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative reviewReview Published on 2020-09-162022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] Activation Admission anticoagulation bleeding event Blood cells Comorbidities complement coronavirus COVID-19 Critically ill patient cytokine release decision described dose Endothelial dysfunction Epidemiology event explained Factors hospital hospital discharge hospitalized patient ICU implication incidence intensive care Interaction life-threatening LMWH low molecular weight management mechanisms pathologic consequence pathophysiologic Patient patients with PE procoagulant Prophylactic Prophylaxis Pulmonary embolism reduced risk reported risk risk factor SARS-CoV-2 Selection therapeutic Thromboprophylaxis unfractionated heparin Venous Thromboembolism VTE VTE risk [DOI] 10.1186/s13613-020-00741-0 PMC 바로가기 [Article Type] Review
Estimation of Renin-Angiotensin-Aldosterone-System (RAAS)-Inhibitor effect on COVID-19 outcome: A Meta-analysisResearch article Published on 2020-08-012022-10-05 Journal: The Journal of Infection [Category] SARS, 유전자 메커니즘, [키워드] ACEi ACEIs analyzed Angiotensin II receptor type 1 blockers Angiotensin II-converting enzyme inhibitors angiotensin-converting enzyme inhibitor ARB ARBs Arterial hypertension blocker cardiovascular disease Comorbidity contrary COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients COVID-19 prognosis Critical Critical disease death diabetes effect size estimation explain higher risk Hospital admission hospitalized patient hypertension hypertensive patient Infection information inhibitor Intervention involved literature Meta-analysis outcomes Patient Prognosis protective effect RAAS RAAS inhibitors random effect receptor reduced risk Result risk of death suggested tested with COVID-19 [DOI] 10.1016/j.jinf.2020.05.052 [Article Type] Research article
Use of distinct anti-hypertensive drugs and risk for COVID-19 among hypertensive people: A population-based cohort study in Southern Catalonia, SpainObservational Study Published on 2020-08-012022-10-05 Journal: Journal of clinical hypertension (Greenwich, Conn. [Category] SARS, 임상, [키워드] age Alter angiotensin II receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors anti-hypertensive drug anti-hypertensive medication blocker calculate Characteristics COVID-19 COVID-19 infection COVID-19 pandemic Cox regression data set database diuretics drugs hazard ratio HRs hypertension hypertensive incidence increased risk inhibitor investigated Laboratory medication multivariable multivariable analyses pandemic PCR PCR-confirmed COVID-19 population-based cohort receiving receptor reduced risk Research retrospective cohort study risk SARS-CoV-2 significantly Spain statistically significant reduction study period Support was used [DOI] 10.1111/jch.13948 PMC 바로가기 [Article Type] Observational Study
Vitamin D Supplementation in Influenza and COVID-19 Infections Comment on: “Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths” Nutrients 2020, 12 (4), 988Comment Published on 2020-06-012022-10-30 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] Comment COVID-19 COVID-19 infection deaths Evidence highlight Influenza nutrient reduced risk reducing risk Vitamin D Vitamin D supplementation [DOI] 10.3390/nu12061626 PMC 바로가기 [Article Type] Comment
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver diseaseMitochondrial Amidoxime Reducing Component 1 유전자의 missense 변이와 간 질환에 대한 보호Research Article Published on 2020-04-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Alanine Alanine transaminase alkaline phosphatase allele Blood blood cholesterol level Blood level blood levels carrier carriers cause of death cholesterol cirrhosis coding variant cohorts component computed tomographic Control death deficiency eight enzyme exhibit fat Fatty liver Genetic genetic finding genetic findings hepatic fat homozygous identify individual LDL cholesterol liver Liver disease liver enzyme loss-of-function MARC1 Missense missense variant mitochondrial phosphatase potential therapeutic target predicted PROTECT reduced reduced risk Total cholesterol variant [DOI] 10.1371/journal.pgen.1008629 PMC 바로가기 [Article Type] Research Article
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성Research Article Published on 2018-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article
Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trialCD4 세포 수가 μL당 500개 이상인 HIV 양성인 사람의 중증 세균 감염 위험에 대한 항레트로바이러스 요법의 즉각적인 개시 효과: 무작위 대조 시험의 2차 결과 결과Articles Published on 2017-01-052022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI AIDS allergy analysed Analysis Antiretroviral therapy ART assigned average Bacterial Bacterial infection Bacterial infections bacterial pneumonia Bildung caused CD4 cell Cell composite endpoint Cox proportional hazard Cox proportional hazards regression Cutoff death defined described disorder Effect Endpoint enrolled European explained extrapulmonary tuberculosis Factor finding Follow-up foundation funding hazard ratio Hospital admissions Immediate Increases increases in Infectious disease Infectious diseases median Medical Research Council multivariable analysis network neutrophil neutrophil count Patient Pneumonia randomised controlled trial recruited reduce reduced risk Registered required risk secondary outcome severity subgroup subgroups Trial Tuberculosis univariable analysis [DOI] 10.1016/S2352-3018(16)30216-8 PMC 바로가기 [Article Type] Articles